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Reaction Progress Kinetic Analysis to Study Organic Reactions: Free On-Demand Online Seminar
Date:5/26/2010

COLUMBIA, Md., May 26 /PRNewswire/ -- Reaction Progress Kinetic Analysis (RPKA) streamlines kinetic studies by exploiting extensive data available from accurate in situ monitoring of global reaction progress under synthetically relevant conditions, where the concentrations of two or more reactants are changing simultaneously – in fact, in the same manner that they are expected to change during practical synthesis. This contrasts with the classical kinetics approach, which uses distorted concentration ratios, typically ca. 10 equivalents, in order to examine the order in each substrate's concentration while holding the other constant.

Concentration dependences of two different substrates may be determined from fewer reaction progress experiments compared to a classical kinetic approach. Reaction Progress Kinetic Analysis methodology is made straightforward for interpretation via graphical manipulation of a mathematically determined minimum set of carefully designed experiments. One advantage of RPKA is vital kinetic information may be rapidly obtained and extracted even in earliest studies of a new reaction and helps inform the direction of both further reaction optimization and fundamental mechanistic investigation by other methods. The method requires little mathematical prowess and no specialized kinetic modeling techniques.

"Kinetics is the branch of chemistry which explains how fast chemical reactions go.  Kinetics enable us to understand driving forces of a reaction, to assess the robustness of catalytic p
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