Convivia(TM) is a proprietary, oral formulation of 4-MP currently in development for the treatment of ALDH2 Deficiency, which is a metabolic disorder characterized by the inability to tolerate alcoholic beverages. Especially prevalent in East Asian populations, ALDH2 deficiency is associated with increased risk of digestive tract cancers and other serious health disorders in affected persons who drink alcoholic beverages.
NASH is a form of progressive liver disease characterized by the accumulation of fat in the liver. It is often diagnosed in people who are overweight, have diabetes or show abnormal serum lipid profiles. The disorder is believed to affect 2 to 5% of the U.S. population. NASH results from fat accumulation in vacuoles of the liver cells resulting in inflammation, which, if allowed to progress may ultimately lead to cirrhosis and liver failure. NASH has most commonly been diagnosed in obese adults, who are insulin resistant, but can also occur in children, the elderly, normal-weight, and non-diabetic persons.
NASH accounts for about 10% of newly diagnosed cases of chronic liver disease. The disorder ranks as one of the leading causes of cirrhosis in the United States, following hepatitis C and alcoholic liver disease. Characteristics of the disease include abnormal levels of liver enzymes in the serum, liver cell injury, and inflammation, fibrosis, and excess fat storage in the liver. Though most people with NASH feel healthy and show no outward signs of liver disease, the progressive nature of NASH can lead to cirrhosis and end-stage liver disease, which may require liver transplantation.
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