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Rapid-Acting Antidepressants Reviewed by NeuroPerspective
Date:12/11/2012

emulates GLYX-13's impact and safety, NRX-1074 would widen the scope of Naurex's market across the full range of depression. In terms of other oral glutamatergic options, companies involved in this area include: NeurOp/Bristol Myers Squibb, Lilly, Roche, BrainCells, and Vanderbilt University.

Alkermes' ALKS5461 program has the burden of its opioid legacy, which would almost certainly result in Schedule II placement, and what may be some initial euphoric/intoxicant effects.

Other depression programs of note include:

Vortioxetine, the triple amine reuptake inhibitor from Lundbeck/Takeda, in NDA-preparation, and Euthymics Bioscience with its triple amine drug, amitifadine. Forest/Pierre Fabre's levomilnacipran is having its NDA prepared. Methylation Sciences is developing a reformulation of SAMe that they believe has much better bioavailability. This could be of interest to patients and prescribers who would perceive it as less "drug," more "nutriceutical."

3) Other neurotherapeutic stories of note in the December issue include:

The successful Phase III results for Acadia Pharmaceuticals' pimavanserin.

An illuminating graphic comparison of the six-month efficacy results for EnVivo's EVP-6124 and Lilly's solanezumab.

About NI Research
NI Research is the leading publisher of independent research on the neurotherapeutics industry, and has developed an unmatched information base regarding both publicly and privately held CNS companies. NeuroPerspective (formerly NeuroInvestment) is the authoritative, independent, monthly review of the neurotherapeutics area, providing critical analysis of therapeutics-in-development.

A one-year subscription to NeuroPerspective is $2,300. The December issue of NeuroPerspective is available for $300 as a single-issue purchase.

NI Research also publishes NeuroLicensing, the Private CNS Company Review, and NeuroSynopsis, a monthly f
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