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Radiesse(R) Dermal Filler Featured Prominently in Journal of Dermatologic Surgery Special Issue on Fillers
Date:6/26/2008

found that, although slightly irregular, the microspheres appear mostly preserved at six months following implantation, consistent with the previously documented long life of the filler material within biological tissue.

In conclusion, the authors established in a small-scale human histological study that "CaHA filler [Radiesse] stimulates new collagen deposition and infiltration around the injected material at six months, which likely contributes to the clinical improvement in the treated rhytids."

The study abstract is available at http://www.blackwell- synergy.com/doi/abs/10.1111/j.1524-4725.2008.34245.x

Neocollagenesis after Injection of Calcium Hydroxylapatite Composition in a Canine Model

This study of six subjects over a period of 4 to 78 weeks, conducted by BioForm Medical, was intended to quantitatively measure the increase in host collagen content in a canine model. The study utilized independent pathologists who were blinded to the time interval of the sample during interpretations.

This study demonstrated increased density of host collagen over time in areas treated with Radiesse dermal filler. The authors concluded that "Although more studies are needed to determine if similar results occur in vivo in humans, injections of calcium hydroxylapatite led to endogenous collagen production in a canine model. This is an important observation because local tissue atrophy and aging facial folds are partially caused by decreased collagen density and increased collagen fragmentation."

The study abstract is available at http://www.blackwell-synergy.com/doi/abs/10.1111/j.1524-4725.2008.34243.x

About BioForm Medical, Inc.:

BioForm Medical, Inc. is a medical aesthetics company headquartered in San Mateo, California, developing products that enhance aesthetic
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SOURCE BioForm Medical, Inc.
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