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Radiesse(R) Dermal Filler Featured Prominently in Journal of Dermatologic Surgery Special Issue on Fillers
Date:6/26/2008

g were conducted by Drs Alastair and Jean Carruthers in Vancouver, British Columbia and the results were evaluated by two blinded evaluators in a private radiology center in New York, New York. Twenty-seven patients were imaged immediately after a 12-month touch up treatment for lipoatrophy. Twenty-three of these patients were also imaged a minimum of 12 months from their initial lipoatrophy treatment. An additional, previously untreated, 15 patients with lipoatrophy and 15 with nasolabial folds were treated with Radiesse and imaged before and immediately after treatment.

Through various radiographic and tomographic evaluations the authors concluded that "This study documents that CaHA does not obscure adjacent structures and would not confound the radiologist with a proper history of its use."

The study investigators added that "The persisting correction [with Radiesse] is most likely due to the production of the patient's collagen induced by the injection of [Radiesse], the latter of which has subsequently disappeared. In other words, the long-term correction provided by [Radiesse] is not due to the continued presence of the beads but to induced fibroplasias."

The study abstract is available at http://www.blackwell-synergy.com/doi/abs/10.1111/j.1524-4725.2008.34247.x

Calcium Hydroxylapatite Filler for Facial Rejuvenation: A Histologic and Immunohistochemical Analysis

This study was conducted to characterize the expression of collagen, using a variety of staining methods, in patients treated with Radiesse. Five subjects were treated in their nasolabial fold and postauricular areas and six months following injection, the patients received biopsies of the postauricular injection area.

The authors were able to confirm the deposition of new collagen around -- and eventual infiltration into -- the filler microspheres and
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SOURCE BioForm Medical, Inc.
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