Navigation Links
RVX-208 Exploratory Study Illustrates Early Potential for Alzheimer's Disease
Date:11/10/2008

Examination (MMSE), and a significant inverse relationship between increased total and LDL cholesterol and learning and memory. Elevated cholesterol levels are thought to increase the production and accumulation of the putative AD neurotoxin, amyloid-beta (A-beta). The A-beta peptide is produced by aberrant cleavage of a larger precursor protein resulting in two lengths, either 42 or 40 amino acids long.

"Stemming from RVX-208's effects on ApoA-I, Prebeta-HDL production and the facilitation of reverse cholesterol transport, we hypothesized that RVX-208 might increase circulating A-beta40 levels through its effects on functional HDL, which can act as a sponge to draw A-beta40 from the brain to the circulation, for enhanced clearance from the body," stated Dr. Sparks. "Although it was a pilot study, with minimal subjects, we were pleased to find a positive signal and look forward to performing further research on RVX-208 in this critical area of unmet medical need," Dr. Sparks added.

"We are pleased and cautious about these early results," stated Kenneth Lebioda, Senior Vice President of Business and Corporate Development of Resverlogix. "This data provides important evidence solidifying our strategy to continue research efforts in this important disease area. We have always maintained a strategic life cycle management strategy that ensures the pursuit of important research in areas of critical unmet need. Our progress in Alzheimer's disease research illustrates our commitment to build a broad portfolio of opportunities in areas of unmet need for our lead drug and our NexVas(TM) platform technology. We look forward to continue our research collaboration with Dr. Sparks in this important medical area."

About RVX-208

RVX-208, a first in class novel small molecule therapeutic that facilitates endogenous Apolipoprotein A-I (ApoA-I) production, is positioned to be one of the most promising emerging drugs in the treatment of atherosclerosis and v
'/>"/>

SOURCE Resverlogix Corp.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related biology technology :

1. International Steering Committee for RVX-208 IVUS Trial Formed
2. Phase 1b/2a Program Commences for RVX-208
3. Industry Leaders Select Resverlogixs RVX-208
4. Dosing for RVX-208 Phase 1a Clinical Study Completed
5. FDA Grants Resverlogix Approval to Commence a Phase 1 Clinical Trial for RVX-208
6. Reverse Cholesterol Transport by RVX-208 a Small Molecule for ApoA-I Production Increase Presented at American Heart Association Scientific Meeting
7. deCODE Study Expands Clinical Utility of deCODE AF(TM) for Improving the Diagnosis of Atrial Fibrillation and Preventing Stroke
8. Interim Analysis of Top-Line Data From Phase II/III Study Shows Favorable Efficacy & Safety for Cortheras Relaxin in Acute Heart Failure
9. Genomic Health Announces Publication of a Study Demonstrating the Oncotype DX(R) Breast Cancer Assay Influences Chemotherapy Treatment Recommendation in 44 Percent of Patients Evaluated
10. New Study Shares Best Practices in Biopharma Public Relations
11. Study From the University of Texas M.D. Anderson Cancer Center Demonstrates That AHCC(R) is Safe in Combination With Most Chemotherapeutic Agents
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/22/2015)... -- According to a new market research ... Electrophoresis, Agarose & Polyacrylamide Gel, Capillary Electrophoresis, Isoelectric Focusing, ... by End User - Global Forecast to 2020", published ... around $1.98 Billion by 2020 with a CAGR of ... Browse 226 ma rket data T ...
(Date:5/22/2015)... 22, 2015 Baylor Research Institute (BRI) ... Genomics Research Institute (TGen) in Phoenix, AZ ... accelerating early detection and treatments for patients with a broad ... will lead to new clinical trials and access to technology ... gap from bench to bedside across Baylor Scott ...
(Date:5/21/2015)... Specialty Pharmacy Times has completed ... to BPA Worldwide as a business publication member. ... data for Specialty Pharmacy Times based on business/distribution, ... a member of BPA Worldwide, Specialty Pharmacy Times ... with the most reliable, unequaled data,” said Chris ...
(Date:5/21/2015)... (PRWEB) May 21, 2015 uBiome, ... announced a partnership with PicnicHealth, a healthcare company ... Participants diagnosed with Inflammatory Bowel Disease (IBD) will ... a complementary uBiome research kit. Both companies were ... , For more information on this ...
Breaking Biology Technology:Electrophoresis Market Worth $1.98 Billion by 2020 2Electrophoresis Market Worth $1.98 Billion by 2020 3Electrophoresis Market Worth $1.98 Billion by 2020 4Precision Medicine Collaboration to Increase Options for Cancer Patients 2Precision Medicine Collaboration to Increase Options for Cancer Patients 3Precision Medicine Collaboration to Increase Options for Cancer Patients 4Specialty Pharmacy Times Joins BPA Worldwide 2uBiome Partners with PicnicHealth 2uBiome Partners with PicnicHealth 3
... ... User Interface and Improved Support for Complex Experiments. , ... (PRWEB) April 12, 2010 -- Genedata, a leading ... Genedata Screener® 8. Developed over the past year to address evolving customer requirements, Genedata ...
... of carbon, is a potential superstar for the electronics ... the material at nearly the speed of light ... graphene could be used to make superfast transistors ... structure exhibits incredible flexibility and mechanical strength, as well ...
... ... Europe for Popular RAPS Workshop on Electronic Regulatory Submissions , ... Rockville, MD (Vocus) April 8, 2010 -- ... Professionals Society (RAPS) will host Preparing Compliant eCTD Submissions in Brussels, 5–7 May. This ...
Cached Biology Technology:Genedata Screener 8 Advancing Analysis of HCS, HTS and Time Series Data Debuts at SBS 16th Annual Conference 2Genedata Screener 8 Advancing Analysis of HCS, HTS and Time Series Data Debuts at SBS 16th Annual Conference 3Genedata Screener 8 Advancing Analysis of HCS, HTS and Time Series Data Debuts at SBS 16th Annual Conference 4Graphene films clear major fabrication hurdle 2Graphene films clear major fabrication hurdle 3RAPS to Host eCTD Submissions Workshop in Brussels 2RAPS to Host eCTD Submissions Workshop in Brussels 3
(Date:5/19/2015)... May 19, 2015 ... the addition of the  "Genetic Testing Market ... (Logo: http://photos.prnewswire.com/prnh/20130307/600769) , ,A recent report, Genetic ... analysis of the current and future genetic ... tests, their working principles and types are ...
(Date:5/14/2015)... --Research and Markets ( http://www.researchandmarkets.com/research/5whpxg/fingerprint ) has ... in Smart Mobile Devices " report to their ... a watershed year for fingerprint sensors in smartphones and ... gave fingerprint sensors a raison d,etre in the mobile ... a must-have feature in flagship smartphones. The ...
(Date:5/11/2015)... , May 11, 2015  Synaptics Incorporated (NASDAQ: ... interface solutions, today announced the appointment of ... Chief Financial Officer, reporting to Rick Bergman ... current Chief Financial Officer, Kathleen Bayless , ... Mr. Ali brings extensive financial management ...
Breaking Biology News(10 mins):Global Genetic Testing Market Outlook 2018 2Global Smart Mobile Devices Fingerprint Sensors Market 2015-2019: Key Vendors are Authentec, Validity Sensors, Fingerprint Cards, Next Biometrics Group. IDEX, and Qualcomm 2Synaptics Appoints Wajid Ali as Senior Vice President and Chief Financial Officer 2
... fruit fly and then moving into mice and humans, researchers at ... gene suppresses cancer in all three organisms. Reciprocally, switching off the ... leads to cancer. The authors show there is a good chance ... They report their findings in two papers in the leading online ...
... from Queen,s University are in India today (Monday) to ... infections which destroy plants and animals. The biotechonology ... of research into the infections which cost the world ... $5.3 billion in animal health each year. A ...
... algorithm that meshes existing data to produce a ... to stimuli. Using this new method, Whitehead Institute ... alpha-synuclein toxicity to identify genes and pathways that ... alpha-synuclein protein in brain cells are a hallmark ...
Cached Biology News:Suppressing cancer with a master control gene 2Reduction in parasite infections ahead for India 2Calculating gene and protein connections in a Parkinson's disease model 2Calculating gene and protein connections in a Parkinson's disease model 3Calculating gene and protein connections in a Parkinson's disease model 4
sodium channel, nonvoltage-gated 1 alpha,...
ANTI PIG LDH H4...
... use in refrigerators, freezers, or liquid nitrogen. Conveniently sized ... for color coding to project, user, lab, etc. Holes ... cool air circulation. Supplied with 9 x 9 (12.7 ... Box dimensions: 13 x 13 x 5.1 cm H ...
Sterile glass 5 mm beads that make spreading bacterial and yeast cultures easy. Can be washed, autoclaved and reused....
Biology Products: