Navigation Links
RPCI-Led Study: FAK Inhibitor Proves Effective Against Brain Tumors in Preclinical Studies
Date:12/29/2012

more effective treatments for glioblastoma,” noted senior author William G. Cance, MD, FACS, Surgeon-in-Chief and Chair of the Department of Surgical Oncology. “The potential impact is great because glioblastomas are such an aggressive tumor, and because we know they produce FAK in especially high quantities.”

The authors also included researchers from the University of California at San Diego and faculty from the Department of Pathology at RPCI. CFAK-Y15 is being developed by CureFAKtor Pharmaceuticals LLC (http://www.curefaktor.com). Drs. Cance and Golubovskaya, both of whom also serve on the management team of CureFAKtor, were part of the team that first identified CFAK-Y15, in research published in the Journal of Medicinal Chemistry in 2008.

The new abstract and paper, “Pharmacological blockade of FAK autophosphorylation decreases human glioblastoma tumor growth and synergizes with temozolomide,” can be accessed online at http://mct.aacrjournals.org/content/early/2012/12/12/1535-7163.MCT-12-0701.

This work was supported by Susan Komen for the Cure Foundation grant BCTR0707148 and three National Cancer Institute (NCI) grants: R01CA065910, R01HL073396, and the NCI’s Cancer Center Support Grant for Roswell Park Cancer Institute (P30CA016056).

The mission of Roswell Park Cancer Institute (RPCI) is to understand, prevent and cure cancer. RPCI, founded in 1898, was one of the first cancer centers in the country to be named a National Cancer Institute-designated comprehensive cancer center and remains the only facility with this designation in Upstate New York. The Institute is a member of the prestigious National Comprehensive Ca
'/>"/>

Source: PRWeb
Copyright©2012 Vocus, Inc.
All rights reserved

0

GOOD

Page: 1 2 3

Related biology technology :

1. Nature Materials study: Boosting heat transfer with nanoglue
2. New Study: Health Professionals Support Biotechnologys Use In Food Products And Sustainable Farming
3. Nature Materials study: Graphene invisible to water
4. Breaking Study: ICU Medicals Tego® Needlefree Connector Proves More Cost Effective Than Traditional Central Venous Catheter Locks
5. Karyopharm Therapeutics Announces Oral Presentation at the American College of Rheumatology (ACR) on the use of Selective Inhibitors of Nuclear Export (SINE) CRM1 Antagonists in preclinical models of Systemic Lupus Erythematosus (SLE)
6. Array BioPharma To Present Clinical Data At The 2012 ASH Meeting On ARRY-520, A KSP Inhibitor, And ARRY-614, A Dual p38/Tie2 Inhibitor
7. Kinase Inhibitors: Global Markets -- Focus on the U.S.
8. Karyopharm Therapeutics announces the Publication of Two Preclinical Studies on the Activity of Selective Inhibitors of Nuclear Export (SINE) in Acute Myeloblastic Leukemia (AML)
9. Arthritis Therapeutics Market to 2018 - Novel Oral JAK Inhibitors and Biologic Disease Modifying Anti-Rheumatic Drugs (DMARD) Will Drive Continued Growth Across Key Indications
10. Lixte Biotechnology Receives US Patent for Its Proprietary Histone Deacetylase Inhibitor
11. Karyopharm Therapeutics Announces Multiple Presentations on Selective Inhibitors of Nuclear Export (SINE) in Solid and Hematologic Malignancy Models and Spontaneous Canine Cancers at the American Association of Cancer Research (AACR) Meeting
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/23/2013)... LAGUNA HILLS, Calif. , May 23, 2013 /PRNewswire-USNewswire/ ... CA recently became the first hospital on ... site robotic technology. This new surgical option provides women ... Marc Winter , ... gynecologist and surgeon and medical director of minimally ...
(Date:5/23/2013)... FL (PRWEB) May 23, 2013 On ... made trips to supermarkets to search for the growing ... store aisles. Results from a year long study were ... level in foods, specifically meats, over previous years. For ... how the growth of antibiotic resistant bacteria in food, ...
(Date:5/23/2013)... The New Jersey chapter of the ... Processing Associates (BDPA), is hosting its 10th annual Families ... all-day event will encourage students and their parents to ... outs from many of the industries’ finest teachers. Held ... Jersey Institute of Technology, the event will include workshops, ...
(Date:5/23/2013)... 2013 During the conduct of ... adhere to principles of good clinical practice (GCP) ... Dr. Jeremy Lim, Fellow, Clinical Development at Novartis ... ,     Understand the International Conference on Harmonization (ICH) ... regulations for the conduction of clinical trials , ...
Breaking Biology Technology:Saddleback Memorial Surgeon First on the West Coast to Perform Single-Site Robotic Hysterectomy 2Saddleback Memorial Surgeon First on the West Coast to Perform Single-Site Robotic Hysterectomy 3Acne Cream, Probiotic Action Shares News on How Some Food may Breed Acne Causing Bacteria 2Black Data Processing Associates (BDPA) New Jersey Hosts 10th Annual Families in Technology Day June 8, 2013 2Adhering to Good Clinical Practice, New Webinar Hosted by Xtalks 2
... Study Published in the Journal of Clinical Oncology Proves Accurate, ... ... Reaction (RT-PCR), REDWOOD CITY, Calif., June 2 Genomic ... of Clinical Oncology,(JCO) published results of a study confirming RT-PCR ...
... AKIVA, Israel, June 2 ITGI Medical, Ltd.,(TASE: ITGI) ... certified,Over and Under(R) Pericardium Covered Stent (PCS) in the ... covered with a heterologous tissue,designed to set a barrier ... is intended for situations such as degenerated Saphenous Vein,Graft ...
... Perceptive Informatics, the,technology subsidiary of PAREXEL International ... it has integrated its leading medical imaging,technology ... image,management and reporting system provided by Digisonics, ... assessment in clinical studies.,The system provides high-performance ...
Cached Biology Technology:Genomic Health Announces Expansion of Oncotype DX(R) Breast Cancer Test to Include Quantitative Estrogen Receptor (ER) and Progesterone Receptor (PR) Scores 2Genomic Health Announces Expansion of Oncotype DX(R) Breast Cancer Test to Include Quantitative Estrogen Receptor (ER) and Progesterone Receptor (PR) Scores 3Genomic Health Announces Expansion of Oncotype DX(R) Breast Cancer Test to Include Quantitative Estrogen Receptor (ER) and Progesterone Receptor (PR) Scores 4Over and Under(R) Pericardium Covered Stent is now in use in England and Proves Great Deliverability 2Perceptive Informatics Enhances Medical Imaging Capabilities for Assessment of Cardiac Function 2Perceptive Informatics Enhances Medical Imaging Capabilities for Assessment of Cardiac Function 3Perceptive Informatics Enhances Medical Imaging Capabilities for Assessment of Cardiac Function 4
(Date:5/22/2013)... must join together in a major new effort to ... in providing Earth,s people with clean water that looms ... a comment article in the current edition of ... the American Chemical Society (ACS), the world,s largest scientific ... Ph.D., and Jerald L. Schnoor, Ph.D., explain that shortages ...
(Date:5/22/2013)... and human health effects from disposal of millions ... scientists to recommend stronger government policies to encourage ... materials. That,s the conclusion of a new paper ... Technology . , Oladele A. Ogunseitan and colleagues ... for powering everything from smart phones to components ...
(Date:5/22/2013)... provide important new details on how climate change will ... 21 in the Journal of Animal Ecology . ... predictions and informing policymakers of how species are likely ... "There is a growing recognition among biologists that climate ... and that this is going to have very important ...
Breaking Biology News(10 mins):UCLA life scientists present new insights on climate change and species interactions 2UCLA life scientists present new insights on climate change and species interactions 3UCLA life scientists present new insights on climate change and species interactions 4UCLA life scientists present new insights on climate change and species interactions 5
... have uncovered intriguing evidence to support the theory that ... of baboons, scientists showed that as these animals age, ... increases. , Over time, cells lose their ability to ... research, published in an advanced online edition of Science, ...
... the best-studied organisms of the open sea, key aspects ... krill is important because they are vital prey for ... to fishing pressure and environmental change. In the February ... American Institute of Biological Sciences, Stephen Nicol of the ...
... uncovered an important mechanism used by the developing brain ... brain that interprets visual signals. In the process, ... decades-old model of how nerve cells establish distant connections ... , In the January 5, 2006, issue of the ...
Cached Biology News:Aging cells, aging body: Fresh evidence for a connection 2Chemical signaling helps regulate sensory map formation in the brain 2Chemical signaling helps regulate sensory map formation in the brain 3
...
Human Regulatory T cell Staining Kit #2 (w/ APC Foxp3 PCH101, FITC CD4, PE CD25)...
Goat anti-VAV2 Class: Antibody Product Group: Miscellaneous Antibody...
Rabbit polyclonal to M13 Bacteriophage Coat Proteins ( Abpromise for all tested applications)....
Biology Products: