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REMINDER: Exelixis Will Webcast Its June 2 Investor and Analyst Briefing at ASCO
Date:5/28/2008

Seven Abstracts Accepted for Presentation at ASCO

SOUTH SAN FRANCISCO, Calif., May 28 /PRNewswire-FirstCall/ -- Exelixis, Inc. (Nasdaq: EXEL) will hold an investor and analyst briefing in conjunction with the 44th Annual Meeting of the American Society of Clinical Oncology (ASCO) from 6:00 p.m. to 8:00 p.m. CT on Monday, June 2, 2008.

Participants:

-- George A. Scangos, PhD, President and Chief Executive Officer

-- Michael M. Morrissey, PhD, President of Research and Development

-- Gisela M. Schwab, MD, Executive Vice President and Chief Medical

Officer

Topics:

-- XL184 (targets: MET, VEGFR2, RET)

-- XL147 (targets: PI3K)

-- XL765 (targets: PI3K, mTOR)

-- XL647 (targets: EGFR, HER2, VEGFR2)

-- XL880* (targets: MET, VEGFR2)

-- XL281 (targets: RAF)

* XL880 was selected by GlaxoSmithKline in December 2007 for further

development and commercialization.

The event will be webcast and may be accessed in the Event Calendar page under Investors at http://www.exelixis.com.

An archived replay of this webcast will be available until 9:00 p.m. PT/12:00 a.m. ET on July 2, 2008. Access numbers for this replay are: 1-888-286-8010 (domestic) and +1-617-801-6888 (international); the replay passcode is: 42662164.

ASCO Presentations

Saturday, May 31

-- XL647 (EGFR, HER2, VEGFR2) -- Poster & Discussion

"A phase 1 study of XL647, an EGFR, HER2, VEGFR2 inhibitor,

administered orally daily to patients (pts) with advanced solid

malignancies (ASM)"

Day: Saturday, May 31

Session: Developmental Therapeutics: Molecular Therapeutics

Time (Poster): 8 a.m.-noon Location: W375e Lobby

Time (Discussion): Noon-1 p.m. Location: W375a

Poster Number: 5 Abstract Number: 3528

Presenter: Heather A. Wakelee, MD

-- XL880* (MET, VEGFR2) -- Poster

"A phase 2 study of the dual MET/VEGFR2 inhibitor GSK1363089 (XL880) in

patients with papillary renal carcinoma (PRC)"

Day: Saturday, May 31

Session: Genitourinary Cancer

Time: 8 a.m.-noon

Location: S Hall A1

Poster Number: 5G Abstract Number: 5103

Presenter: Ramiprasad Srinivasan, MD, PhD

-- XL765 (PI3K, mTOR) -- Oral Presentation

"A phase 1 dose-escalation study of the safety, pharmacokinetics (PK),

and pharmacodynamics (PD) of a novel PI3K inhibitor, XL765,

administered orally to patients (pts) with advanced solid tumors"

Day: Saturday, May 31

Session: PI-3 Kinase/mTOR Directed Agents

Time: 1:45-2:15 pm

Location: W375a

Abstract Number: 3510

Presenter: Kyriakos Papadopoulis, MD

* XL880 was selected by GlaxoSmithKline in December 2007 for further

development and commercialization.

Sunday, June 1

-- XL184 (RET, MET, VEGFR2) -- Oral Presentation

"A phase 1 study of XL184, a RET, VEGFR2, and MET kinase inhibitor, in

patients (pts) with advanced malignancies, including pts with medullary

thyroid cancer (MTC)"

Day: Sunday, June 1

Session: Developmental Therapeutics: Molecular Therapeutics

Time: 10-10:15 a.m.

Location: W375a

Abstract Number: 3522

Presenter: Ravi Salgia, MD, PhD

-- XL647 (EGFR, HER2, VEGFR2) -- Poster

"Activity of XL647 in clinically selected NSCLC patients (pts) enriched

for the presence of EGFR mutations: Results from phase 2"

Day: Sunday, June 1

Session: Lung Cancer-Metastatic

Time: 2-6 p.m.

Location: S Hall A1

Poster Number: 42H Abstract Number: 8053

Presenter: Naiyer A Rizvi, MD

Monday, June 2

-- XL647 (EGFR, HER2, VEGFR2) - Poster & Discussion

"Activity and tolerance of XL647 in NSCLC patients with acquired

resistance to EGFR-TKIs: Preliminary results of a phase 2 trial"

Day: Monday, June 2

Session: Lung Cancer -- Metastatic

Time (Poster): 8 a.m.-noon Location: W375e Lobby

Time (Discussion): Noon-12:15 p.m. Location: W375d

Poster Number: 9 Abstract Number: 8028

Presenter: Vincent A. Miller, MD

-- XL880* (MET, VEGFR2) -- Poster

"Preliminary activity of GSK1363089 (XL880), a dual MET/VEGFR2

inhibitor, in MET amplified poorly differentiated gastric cancer

(PDGC): Interim results of a multicenter phase 2 study"

Day: Monday, June 2

Session: Gastrointestinal (Noncolorectal) Cancer

Time: 8 a.m.-noon

Location: S Hall A1

Poster Number: 33D Abstract Number: 4572

Presenter: Minaxi P. Jhawer, MD

* XL880 was selected by GlaxoSmithKline in December 2007 for further

development and commercialization.

About Exelixis

Exelixis, Inc. is a development-stage biotechnology company dedicated to the discovery and development of novel small molecule therapeutics for the treatment of cancer and other serious diseases. The company is leveraging its fully integrated drug discovery platform to fuel the growth of its development pipeline, which is primarily focused on cancer. Currently, Exelixis' broad product pipeline includes investigational compounds in phase 2 and phase 1 clinical development. Exelixis has established strategic corporate alliances with major pharmaceutical and biotechnology companies, including GlaxoSmithKline, Bristol-Myers Squibb, Genentech, Wyeth Pharmaceuticals, and Daiichi-Sankyo. For more information, please visit the company's web site at http://www.exelixis.com.

Exelixis and the Exelixis logo are registered U.S. trademarks.


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