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Quest Diagnostics to Present Genomic Studies Related to New Testing Techniques for Leukemia and Prostate Cancer at 2009 ASCO Meeting
Date:5/28/2009

d in 40%-85% of prostate cancer (PCa) patients and have not been found in normal individuals or those with benign prostate hyperplasia (BPH). However, multiple partner genes, including ETS transcription genes, and breakpoints have been reported. Scientists at Quest Diagnostics Nichols Institute developed a laboratory test based on TMPRSS2 5' and 3' intragenic differential expression (IDE) to identify patients with prostate cancer vs. benign prostatic hyperplasia (BPH). Although work is needed to improve plasma RNA quality, the scientists concluded that IDE of plasma TMPRSS2 may be a useful non-invasive diagnostic or prognostic tool. Abstract title: "Intragenic expression profile in tissue and plasma for the detection of TMPRSS2 rearrangements associated with prostate cancer." (Abstract No: 5162) Link to ASCO abstract: http://www.abstract.asco.org/AbstView_65_34640.html.

Quest Diagnostics is the world's leading cancer diagnostics company. The company's Leumeta(TM) family of plasma-based molecular tests were the first available to doctors for directly identifying markers of hematologic cancers in blood plasma rather than painfully extracted bone marrow biopsies when introduced in 2006. Since that time, the Leumeta test family has grown to include more than 20 tests. The company continues to focus on developing its Leumeta test line in order to develop new testing techniques for solid tumors, such as prostate cancer, as well as for hematologic cancers. In addition, in February 2009, the company formed licensing agreements to rights to use biomarkers owned by Epigenomics and Health Discovery Corporation with the goal of developing new laboratory tests for detecting prostate cancer in blood and urine.

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