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Quest Diagnostics to Present Genomic Studies Related to New Testing Techniques for Leukemia and Prostate Cancer at 2009 ASCO Meeting
Date:5/28/2009

with chronic myeloid leukemia (CML): Scientists from Quest Diagnostics, University of Texas M. D. Anderson Cancer Center, and Consortium for Bioinformatics demonstrated that 73 percent of patients with CML who are resistant to treatment with imatinib exhibited the presence of alternatively spliced BCR-ABL1 mRNA with a 35-bp insertion (BCR-ABL135INS). The scientists also determined that imatinib, when combined with nilotinib or homoharringtonine (HHT), showed strong synergy, overcoming BCR-ABL135INS-induced resistance in vitro. The findings emphasize the importance of the overlooked alternatively spliced BCR-ABL135INS protein and may provide a strategy to treat resistant disease and eradicate residual CML. Abstract title: "Alternatively spliced truncated BCR-ABL1 protein in CML patients with resistance to kinase inhibitors." (Abstract No: 7026) Link to ASCO abstract: http://www.abstract.asco.org/AbstView_65_33284.html.

In addition, scientists from Quest Diagnostics and M.D. Anderson Cancer Center identified three novel (previously undescribed) mutations along the BCR-ABL tyrosine kinase that may constitute a new class of mutations that "confer significant drug resistance" to imatinib therapy by expressing a truncated BCR-ABL1. Abstract title: "BCR-ABL1 truncation due to premature translation termination as a mechanism of resistance to kinase inhibitors." (Abstract No: 7028) Link to ASCO abstract: http://www.abstract.asco.org/AbstView_65_33182.html.

-- Testing for gene rearrangement and partner genes to enhance detection of prostate cancer: TMPRSS2 gene rearrangements have been reporte
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