Navigation Links
Quest Diagnostics to Present Genomic Studies Related to New Testing Techniques for Leukemia and Prostate Cancer at 2009 ASCO Meeting
Date:5/28/2009

with chronic myeloid leukemia (CML): Scientists from Quest Diagnostics, University of Texas M. D. Anderson Cancer Center, and Consortium for Bioinformatics demonstrated that 73 percent of patients with CML who are resistant to treatment with imatinib exhibited the presence of alternatively spliced BCR-ABL1 mRNA with a 35-bp insertion (BCR-ABL135INS). The scientists also determined that imatinib, when combined with nilotinib or homoharringtonine (HHT), showed strong synergy, overcoming BCR-ABL135INS-induced resistance in vitro. The findings emphasize the importance of the overlooked alternatively spliced BCR-ABL135INS protein and may provide a strategy to treat resistant disease and eradicate residual CML. Abstract title: "Alternatively spliced truncated BCR-ABL1 protein in CML patients with resistance to kinase inhibitors." (Abstract No: 7026) Link to ASCO abstract: http://www.abstract.asco.org/AbstView_65_33284.html.

In addition, scientists from Quest Diagnostics and M.D. Anderson Cancer Center identified three novel (previously undescribed) mutations along the BCR-ABL tyrosine kinase that may constitute a new class of mutations that "confer significant drug resistance" to imatinib therapy by expressing a truncated BCR-ABL1. Abstract title: "BCR-ABL1 truncation due to premature translation termination as a mechanism of resistance to kinase inhibitors." (Abstract No: 7028) Link to ASCO abstract: http://www.abstract.asco.org/AbstView_65_33182.html.

-- Testing for gene rearrangement and partner genes to enhance detection of prostate cancer: TMPRSS2 gene rearrangements have been reporte
'/>"/>

SOURCE Quest Diagnostics
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related biology technology :

1. ImmuneRegen Responds to Defense Threat Reduction Agency Request for Information
2. NovaQuest Advances Virtual Development Model With Strategic Investment in TOPIGEN Pharmaceuticals
3. Quest Diagnostics to Speak at the 2007 UBS Global Life Sciences Conference
4. VioQuest Pharmaceuticals to Present at BIO InvestorForum in San Francisco
5. Quest Diagnostics Joins National ePrescribing Patient Safety Initiative (NEPSI)
6. University HealthSystem Consortium Chooses SciQuest to Optimize Medical Research Procurement
7. VioQuest Pharmaceuticals to Present at the Paramount BioSciences Healthcare Conference
8. Sinovac Requests Extension for Annual Shareholders Meeting
9. Maryland Stem Cell Commission Issues Nationwide Request for Applications for New Post-Doctoral Fellowship Grants
10. AmSurg Selects SciQuest Eprocurement Solution to Automate Purchasing of Medical Goods and Services
11. Quest PharmaTech to Receive $3,000,000 to Develop Oncology Products Based on its SonoLight Technology
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2014)... 21, 2014  Four-dimensional (4-D) printing develops materials ... external stimuli such as changes in temperature. This ... effect in multiple industries.  In the near future, ... printing objects ranging from human organs to parts ... Logo - http://photos.prnewswire.com/prnh/20140820/138289 ...
(Date:8/21/2014)... August 21, 2014 Gallus ... contract development and manufacturing organization (CMO) announced today ... Inc., an oncology company focused on the development ... to manufacture the anti-prostate specific membrane antigen (PSMA) ... candidate. Under the agreement the antibody will ...
(Date:8/20/2014)... 20, 2014 Clintrax Global, Inc., a ... Raleigh, NC , recently announced ... Vice President of Administration. As ... corporate processes, including their alignment with company objectives ... worked as an HR executive, specializing in needs ...
(Date:8/20/2014)... the first time, chemists have succeeded in measuring vibrational ... resolution. The study reveals how vibration of a single ... , The study was performed at the University ... the University of Jyvskyl works as a visiting fellow ... the study. The second team was lead by Professor ...
Breaking Biology Technology:Frost & Sullivan: 4-D Printing to Usher in Age of Low-Labor, Fast-Paced Product Manufacturing 2Frost & Sullivan: 4-D Printing to Usher in Age of Low-Labor, Fast-Paced Product Manufacturing 3Frost & Sullivan: 4-D Printing to Usher in Age of Low-Labor, Fast-Paced Product Manufacturing 4Gallus Enters Agreement with Progenics Pharmaceuticals, Inc. for Manufacture of Anti-PSMA Monoclonal Antibody 2Gallus Enters Agreement with Progenics Pharmaceuticals, Inc. for Manufacture of Anti-PSMA Monoclonal Antibody 3Clintrax Global, Inc. Announces Addition to Executive Team 2Seeing a molecule breathe 2
... semiconductor techniques invented by University of Wisconsin-Madison ... to an amazing array of materials. , ,Historically, ... upon which to grow and etch the thin films ... other electronic devices. But as thin as those chips ...
... Wis. - A product for molecular diagnostics and ... to the global distribution capability of Prodesse, Inc. ... of a new license agreement, Prodesse will add to ... extension (LUX) technology from the Carlsbad, Calif.-based Invitrogen ...
... - Following the announcement of increased quarterly revenues, ... technology, once again projected cash flow break even for ... projected for 2007. , ,Chairman and CEO Rimas Buinevicius ... Foundry's 2006 third quarter in a live Webcast conference ...
Cached Biology Technology:UW produces fast and flexible computer chip 2Prodesse joins forces with Invitrogen 2Sonic closer to turning profit corner 2Sonic closer to turning profit corner 3Sonic closer to turning profit corner 4
(Date:8/21/2014)... Fram Strait is a key region in the global oceanic ... and Svalbard warm Atlantic water flows to the north into ... water masses and sea ice push their way out of ... the Atlantic water cools here on its way to the ... water caused in this manner drives the global band of ...
(Date:8/21/2014)... RUSTON, La. A team of researchers ... innovative method for using affordable, consumer-grade 3D ... implants that can contain antibacterial and chemotherapeutic ... team comprised of doctoral students and research ... nanosystems engineering programs collaborated to create filament ...
(Date:8/20/2014)... pregnant teenagers in Rochester, NY, nearly half engaged in ... cornstarch, vacuum dust, baby powder and soap, and other ... such teens had significantly lower iron levels as compared ... Pregnant teens, regardless of pica, are at higher risk ... and anemia. Low iron in pregnant teens raises the ...
Breaking Biology News(10 mins):Arctic sea ice influenced force of the Gulf Stream 2Arctic sea ice influenced force of the Gulf Stream 3Louisiana Tech University researchers use 3D printers to create custom medical implants 2Louisiana Tech University researchers use 3D printers to create custom medical implants 3Pica in pregnant teens linked to low iron 2
... to assess the environmental risks posed by pharmaceuticals are ... researcher from the University of Gothenburg (Sweden) who is ... we need to include the combined effects of different ... really is," says Sara Brosch from the Department of ...
... Scientific Program of the 2010 American Academy of ... (MEACO) Joint Meeting includes a report on ... with certain incurable retinal diseases. The AAO-MEACO meetingthe ... session October 16 through 19 at McCormick Place, ...
... A total of 15 world renowned cognitive scientists have been ... the 6th Decade of the Mind Conference to be held ... organised by A*STAR,s Institute of High Performance Computing (IHPC), MINDEF,s ... it is the first such conference in Asia to promote ...
Cached Biology News:Environmental risk assessment of pharmaceuticals inadequate 2Singapore hosts first 'Decade of the Mind' conference in Asia 2Singapore hosts first 'Decade of the Mind' conference in Asia 3
ABCA1 Immunogen: Mouse ABCA1-expressing HeLa stable transfectants. Storage: -20 C, Avoid Freeze/Thaw Cycles...
Goat polyclonal to SART3 ( Abpromise for all tested applications). Antigen: Synthetic peptide: MSNADFAKLFLRK, corresponding to C terminal amino acids 951-963 of Human SART3 Entrez Gene ID: 9...
Hamartin/TSC1 (1B2) Mouse mAb Ship: Hot Store: -20 C...
synaptotagmin XIV-like [Source:RefSeq_peptide;Acc:NP_114120] Antigen: Recombinant Protein Epitope Signature Tag (PrEST)....
Biology Products: