Navigation Links
Quest Diagnostics Introduces Molecular Blood Test for Aiding Colorectal Cancer Detection
Date:1/11/2010

MADISON, N.J., Jan. 11 /PRNewswire-FirstCall/ -- A new blood test that identifies changes in DNA associated with colorectal cancer is now available in the U.S. through Quest Diagnostics Incorporated (NYSE: DGX), the world's leading cancer diagnostics company. The test is designed to aid the detection of colorectal cancer, the third leading cause of cancer-related deaths.

The new test is based on DNA methylation of the Septin9 gene, a proprietary biomarker associated with colorectal cancer that was identified by Epigenomics AG (Frankfurt, Prime Standard: ECX), a cancer molecular diagnostics company. Quest Diagnostics is the first commercial laboratory in the U.S. to offer a laboratory-developed test based on the Septin9 biomarker.

"Early detection rates are dismally low, largely because many patients find existing tests and procedures invasive or unpleasant," said Jon R. Cohen, M.D. senior vice president and chief medical officer, Quest Diagnostics. "Our ColoVantage(TM) test, which is based on Septin9, has yet to be clinically validated as a screening test. Rather, it may promote further evaluation in patients who have resisted testing in the past or as an adjunct to existing procedures."

Colorectal cancer treated in localized, early stages has a five-year survival rate of 90 percent. Yet, only 40 percent of cases are diagnosed in early stages, due to low screening rates.

Epigenomics has demonstrated in more than a half dozen peer-reviewed studies involving approximately 3,000 specimens of patients with diagnosed colorectal cancer and of healthy control subjects that methylated Septin9 in blood plasma indicates an increased likelihood of colorectal cancer. Epigenomics is sponsoring a multi-center clinical study named PRESEPT in collaboration with Quest Diagnostics and other organizations to evaluate the Septin9 biomarker's performance for colorectal cancer screening in screening-guideline-eligible individuals who have not been diagnosed with colorectal cancer. Epigenomics expects to conclude the PRESEPT trial early this year with the release of preliminary data, and publish the detailed findings later in 2010.

Quest Diagnostics is a leader in colorectal cancer diagnostics. The company's InSure(R) fecal immunochemical test (FIT) is an FDA-cleared fecal occult blood test (FOBT) for use in screening for sources of lower gastrointestinal bleeding, based on laboratory testing of a stool-based specimen. The company also offers mutation testing to help predict if a patient with metastatic colorectal cancer will respond to certain therapies and genetic testing to aid in evaluating a patient's inherited predisposition to colorectal cancer. In addition, the company provides anatomic pathology testing services for colorectal cancer, such as biopsy testing of tissues identified through colonoscopy.

About Colorectal Cancer Testing and Procedures

Colorectal cancer, which refers to cancer of the colon and rectum, is a major source of cancer death in the U.S. and worldwide. An estimated 106,000 new cases were diagnosed and 50,000 deaths from the disease occurred in the U.S. in 2009. According to the American Cancer Society (ACS), beginning at age 50, both men and women at average risk for developing colorectal cancer should be screened by one of several established tests. People with certain risk factors, such as a family history, may be indicated for earlier or more frequent testing. Such methods include colonoscopy, the screening gold standard, once every ten years, as well as flexible sigmoidoscopy, virtual colonoscopy and double-contrast barium enema every five years or FOBTs, including FITs, annually. Any positive test result of any non-colonoscopy methods should be followed up by colonoscopy.( )

About Quest Diagnostics

Quest Diagnostics is the world's leading provider of diagnostic testing, information and services that patients and doctors need to make better healthcare decisions. The company offers the broadest access to diagnostic testing services through its network of laboratories and patient service centers, and provides interpretive consultation through its extensive medical and scientific staff. Quest Diagnostics is a pioneer in developing innovative diagnostic tests and advanced healthcare information technology solutions that help improve patient care. Additional company information is available at www.QuestDiagnostics.com.



    Contacts:
    Wendy Bost (Media): 973-520-2800
    Kathleen Valentine (Investors): 973-520-2900


SOURCE Quest Diagnostics Incorporated

RELATED LINKS
http://www.questdiagnostics.com

'/>"/>

SOURCE Quest Diagnostics Incorporated
Copyright©2010 PR Newswire.
All rights reserved

Related biology technology :

1. Quest Diagnostics Declares Quarterly Cash Dividend
2. HemaQuest Pharmaceuticals Presents Promising Results in Sickle Cell Disease and Beta Thalassemia
3. MONITORING FORCE GmbH Requests Acknowledgment of Flibanserin as "Orphan Drug"
4. Hungarian Cancer Formula Producer Questions U.S. Introduction of AveUltra
5. SciScout LLC Launches SciAnswers.com, a Science-Based Questions and Answers (Q&A) Site with a Social Networking Perspective.
6. GenomeQuest Places ChIP-Seq Workflow Solution On SDM “Cloud”
7. Quest PharmaTech Acquires Late-Stage Immunotherapeutic Antibody Pipeline
8. GeoVax Labs Requests pre-IND Meeting With FDA
9. Stemedica Requests Pre-IND Meeting With FDA
10. Five Questions About Protopic (tacrolimus) Ointment
11. FDA Grants First Authorization of a Commercial 2009 H1N1 Flu Test for use During Pandemic Flu Emergency to Quest Diagnostics Focus Diagnostics Business
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/20/2017)... ... January 20, 2017 , ... ... the next evolution in spinal fusion, the MISquito Percutaneous Pedicle Screw System ... competition, SpineFrontier is focused on technique driven product solutions that provide maximum ...
(Date:1/19/2017)... Jan. 19, 2017 /PRNewswire -- WuXi AppTec, a ... capability and technology platform, today announced that it ... focused preclinical drug discovery contract research organization (CRO). ... a wholly-owned subsidiary of WuXi, and will continue ... providing greater services. The acquisition will further strengthen ...
(Date:1/19/2017)... GAITHERSBURG, Md. , Jan. 19, 2017 ... Inc., a privately-held immunotherapeutics company targeting infectious diseases, ... for the merger of PharmAthene and Altimmune in ... Venture Fund, HealthCap, Truffle Capital and Redmont Capital. ... diversified immunotherapeutics company with four clinical stage and ...
(Date:1/19/2017)... Linda, Ca (PRWEB) , ... January 18, 2017 ... ... virtual events for tech innovators, engineers, and scientists from around the world, was ... American News. The awards program is based entirely on merit and decided upon ...
Breaking Biology Technology:
(Date:1/11/2017)... 2017 Intoxalock, a leading ignition interlock provider, ... its patent-pending calibration device. With this new technology, Intoxalock ... upload data logs and process repairs at service center ... "Fighting drunk driving through the application of cutting-edge technologies ... but also for the customer who can get back ...
(Date:1/6/2017)... Calif. , Jan. 5, 2017  Delta ID ... its iris scanning technology for automotive at CESĀ® 2017. ... GNTX ) to demonstrate the use of iris ... identify and authenticate the driver in a car, and ... during the driving experience. Delta ID and ...
(Date:12/22/2016)...  As part of its longstanding mission to improve genetic ... recently released its latest children,s book, titled The ... the topics of inheritance and variation of traits that are ... elementary school classrooms in the US. The ... Ariana Killoran , whose previous book with 23andMe, ...
Breaking Biology News(10 mins):