Navigation Links
Quark Pharmaceuticals Presented At ARVO Data Showing That PF-04523655 Enters Retinal Cells And Elicits Its Pharmacologic Effect Via Target Gene Knock-Down Without Activating TLR3
Date:5/11/2009

FREMONT, Calif., May 11 /PRNewswire/ -- Quark Pharmaceuticals, Inc., a development-stage pharmaceutical company discovering and developing novel RNA interference (RNAi)-based therapeutics, today announced that Elena Feinstein, M.D., Ph.D., Chief Scientific Officer, presented a study titled, "PF-04523655 (REDD14NP), an siRNA Compound Targeting RTP801, Penetrates Retinal Cells Producing Target Gene Knockdown and Avoiding TLR3 Activation," at the Association for Research in Vision and Ophthalmology (ARVO) Annual Meeting, taking place from May 3-7, 2009, in Fort Lauderdale, Florida. PF-04523655 is currently being studied by partners Pfizer and Quark in patients with diabetic macular edema (DME) and age-related macular degeneration (AMD).

The study presented at ARVO was performed in collaboration with Dr. Jayakrishna Ambati at the Department of Ophthalmology and Visual Sciences, University of Kentucky College of Medicine, Lexington, KY. The objective of the study was to determine whether PF-04523655, a synthetic chemically modified 19-bp siRNA, enters cells in the retina leading to downregulation of its target gene while avoiding activation of Toll Like Receptor 3 (TLR3). Previous studies from Dr. Ambati's laboratory have shown that unmodified 21-mer siRNA molecules exhibit antiangiogenic effects by inadvertently activating TLR3 rather than down-regulating expression of their target genes. Results obtained in vivo and in vitro indicated that PF-04523655 does enter cells in the retina and elicits its pharmacologic effect via target gene knock-down without activating TLR3.

Daniel Zurr, Ph.D., President and Chief Executive Officer, said, "We believe that the results presented at ARVO continue to substantiate our leadership in siRNA therapeutics, in particular Quark's ability to develop highly specific siRNA products and advance them through the clinic toward commercialization. Quark's ability to establish col
'/>"/>

SOURCE Quark Pharmaceuticals, Inc.
Copyright©2009 PR Newswire.
All rights reserved

0

GOOD

Page: 1 2 3

Related biology technology :

1. Quark Pharmaceuticals to Participate in 9th Annual Beyond Genome Conference
2. FDA Approves Quark IND for DGFi, an siRNA Therapeutic Based on Silence Therapeutics Unique Proprietary Chemistry
3. Quark Pharmaceuticals Announces Poster Presentations at RNAi Europe 2008
4. Quark Pharmaceuticals to Present at American Society for Pharmacology and Experimental Therapeutics Annual Meeting
5. Vion Pharmaceuticals Pays Interest on 7.75% Convertible Senior Notes
6. China Biopharmaceuticals Holdings Announces Second Quarter 2007 Financial Results
7. Vion Pharmaceuticals Completes Accrual of 85 Patients to its Pivotal Phase II Trial of Cloretazine(R) (VNP40101M) in Elderly AML
8. XTL Biopharmaceuticals Announces Financial Results for the Six Months Ended June 30, 2007
9. Cadence Pharmaceuticals Reports Second Quarter 2007 Financial Results
10. Nabi Biopharmaceuticals to Present at Upcoming Industry Conferences
11. Anadys Pharmaceuticals Appoints Steve Worland, Ph.D. as President and Chief Executive Officer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/3/2009)... Pharmaceuticals, Inc. (Nasdaq: VIAP ), a biotechnology company ... of cardiovascular and metabolic disease, today announced that it ... 2 FDG-PET clinical trial of VIA-2291. ,, The ... at five sites in the US and Canada including ...
(Date:12/3/2009)... India, Dec. 3 /PRNewswire-Asia/ -- Dr. Susan Jiang, ... Co. Ltd.,( http://www.beikebiotech.com ), spoke at a ... India, November 22, 2009. Beike is China,s leading,stem ... The conference, organized by the ...
(Date:12/2/2009)... YORK, Dec. 2 Reportlinker.com announces that ... in its catalogue: ,, Drug Discovery ... Trends & Opportunities ,, http://www.reportlinker.com/p0164246/Drug-Discovery-Technologies---A-Global-Update-of-Market-Trends--Opportunities.html ... integral and ongoing element of every pharmaceutical ...
(Date:12/2/2009)... December 2 , ... Heritage" , Coinciding with ... the,Gabonese Republic is hosting an international conference in ... in Africa. The,conference will be attended by government ...
Breaking Biology Technology:VIA Pharmaceuticals Completes Patient Visits in Phase 2 Trial of VIA-2291 2VIA Pharmaceuticals Completes Patient Visits in Phase 2 Trial of VIA-2291 3VIA Pharmaceuticals Completes Patient Visits in Phase 2 Trial of VIA-2291 4Beike Biotechnology CSO Speaks on Role of Stem Cells in Treating Diabetic Foot Disease at IPA Diabetic Foot Care Conference, India 2Beike Biotechnology CSO Speaks on Role of Stem Cells in Treating Diabetic Foot Disease at IPA Diabetic Foot Care Conference, India 3Reportlinker Adds Drug Discovery Technologies - A Global Update of Market Trends & Opportunities 2Reportlinker Adds Drug Discovery Technologies - A Global Update of Market Trends & Opportunities 3Reportlinker Adds Drug Discovery Technologies - A Global Update of Market Trends & Opportunities 4Reportlinker Adds Drug Discovery Technologies - A Global Update of Market Trends & Opportunities 5Reportlinker Adds Drug Discovery Technologies - A Global Update of Market Trends & Opportunities 6Reportlinker Adds Drug Discovery Technologies - A Global Update of Market Trends & Opportunities 7Reportlinker Adds Drug Discovery Technologies - A Global Update of Market Trends & Opportunities 8Reportlinker Adds Drug Discovery Technologies - A Global Update of Market Trends & Opportunities 9Libreville International Conference 2-3 June 2010 2
... ... at Beijing Ag Summit, BEIJING, April 25 ... sectors will help increase,farm productivity in the country and increase total ... DuPont Crop,Genetics Research and Development, told attendees at the "Globalization of,the ...
... in Changzhou Hi-Tech ... District, China, ... animal vaccines was recently launched in,Changzhou National High-tech District, east China,s ... leading overseas scientists. It is,reported that it is the first time ...
... PHILADELPHIA, April 25 /PRNewswire-FirstCall/,-- Shire plc (LSE: SHP, NASDAQ: SHPGY) ... to March,31, 2008., Q1 2008 Financial Highlights, ... product sales(1) $216m, 34% of product sales (2007: 13%) ... GAAP Operating income up 15% to $163m - Non ...
Other Biology Technology:DuPont Partnering with China to Increase Farm Productivity 2DuPont Partnering with China to Increase Farm Productivity 3Leading Overseas Scientists Establish High-Tech Bio-Pharmaceutical Enterprise in Changzhou 2Leading Overseas Scientists Establish High-Tech Bio-Pharmaceutical Enterprise in Changzhou 3Following a Good Start to the Year Shire Reaffirms Full Year 2008 Financial Guidance 2Following a Good Start to the Year Shire Reaffirms Full Year 2008 Financial Guidance 3Following a Good Start to the Year Shire Reaffirms Full Year 2008 Financial Guidance 4Following a Good Start to the Year Shire Reaffirms Full Year 2008 Financial Guidance 5Following a Good Start to the Year Shire Reaffirms Full Year 2008 Financial Guidance 6Following a Good Start to the Year Shire Reaffirms Full Year 2008 Financial Guidance 7Following a Good Start to the Year Shire Reaffirms Full Year 2008 Financial Guidance 8Following a Good Start to the Year Shire Reaffirms Full Year 2008 Financial Guidance 9Following a Good Start to the Year Shire Reaffirms Full Year 2008 Financial Guidance 10Following a Good Start to the Year Shire Reaffirms Full Year 2008 Financial Guidance 11Following a Good Start to the Year Shire Reaffirms Full Year 2008 Financial Guidance 12Following a Good Start to the Year Shire Reaffirms Full Year 2008 Financial Guidance 13Following a Good Start to the Year Shire Reaffirms Full Year 2008 Financial Guidance 14Following a Good Start to the Year Shire Reaffirms Full Year 2008 Financial Guidance 15Following a Good Start to the Year Shire Reaffirms Full Year 2008 Financial Guidance 16Following a Good Start to the Year Shire Reaffirms Full Year 2008 Financial Guidance 17Following a Good Start to the Year Shire Reaffirms Full Year 2008 Financial Guidance 18Following a Good Start to the Year Shire Reaffirms Full Year 2008 Financial Guidance 19Following a Good Start to the Year Shire Reaffirms Full Year 2008 Financial Guidance 20Following a Good Start to the Year Shire Reaffirms Full Year 2008 Financial Guidance 21Following a Good Start to the Year Shire Reaffirms Full Year 2008 Financial Guidance 22Following a Good Start to the Year Shire Reaffirms Full Year 2008 Financial Guidance 23Following a Good Start to the Year Shire Reaffirms Full Year 2008 Financial Guidance 24Following a Good Start to the Year Shire Reaffirms Full Year 2008 Financial Guidance 25Following a Good Start to the Year Shire Reaffirms Full Year 2008 Financial Guidance 26Following a Good Start to the Year Shire Reaffirms Full Year 2008 Financial Guidance 27Following a Good Start to the Year Shire Reaffirms Full Year 2008 Financial Guidance 28Following a Good Start to the Year Shire Reaffirms Full Year 2008 Financial Guidance 29Following a Good Start to the Year Shire Reaffirms Full Year 2008 Financial Guidance 30Following a Good Start to the Year Shire Reaffirms Full Year 2008 Financial Guidance 31Following a Good Start to the Year Shire Reaffirms Full Year 2008 Financial Guidance 32
(Date:12/4/2009)... German . , A new study of ... to understand the positive effect of dietary restriction on healthy ... have shown that dietary restriction increases longevity, but with a ... fruit fly reproduces less frequently with a reduced litter size ...
(Date:12/3/2009)... and his co-workers discovered that specific types of human ... how these pathogens cause cells to degenerate. It is ... E6 and E7. Both proteins switch off different cellular ... Dr. Frank Rsl and his co-workers at DKFZ have ...
(Date:12/3/2009)... , Preliminary Press Conference Topics, Last Call! Press ... Attention PIOs: Sending Press Releases to Fall meeting, ... News Media registration information , News Media Registration ... coming, , For important information regarding visas ...
Breaking Biology News(10 mins):How nutrition affects healthy aging 2Papillomavirus silences innate immune response 2AGU fall meeting: Preliminary press conference topics, press pre-registration deadline 2AGU fall meeting: Preliminary press conference topics, press pre-registration deadline 3AGU fall meeting: Preliminary press conference topics, press pre-registration deadline 4AGU fall meeting: Preliminary press conference topics, press pre-registration deadline 5AGU fall meeting: Preliminary press conference topics, press pre-registration deadline 6Onyx Pharmaceuticals to Host Investor Briefing Following ECCO ESMO Oncology Congress 58301 1Corn Refiners Association Comments on Findings in Recent Report on Sugars and High Blood Pressure 58297 1Corn Refiners Association Comments on Findings in Recent Report on Sugars and High Blood Pressure 58297 2Free Wheelchair Mission Listed by Ministry Watch as Top 30 Shining Light Exemplary Ministry for 2008 58293 1Free Wheelchair Mission Listed by Ministry Watch as Top 30 Shining Light Exemplary Ministry for 2008 58293 2
... Pennsylvania researchers have uncovered an important step in how ... its outer coat to gain entry into healthy cells ... they have demonstrated the effectiveness of monitoring these protein ... the Proceedings of the National Academy of Sciences, provide ...
... for people planning their day. Now with the help of ... include predictions of air quality, a feat that is becoming ... predict that an operational system of routine, global forecasts of ... is only a few years away. Such a system could ...
... tend to involve localized changes in sea surface temperature, ... the more uniform patterns of global warming, a report ... over the effect of global warming on hurricanes, it ... favorable environment for hurricane development and intensification. However, several ...
Other Biology News:Penn researchers shine the light of venus to learn how the herpes virus invades cells 2Air quality forecasts see future in space 2Air quality forecasts see future in space 3Climate's remote control on hurricanes 2
14-3-3 tau Antibody Shipping Temperature: HOT Storage Temperature: -20C...
... Rabbit polyclonal to ThPok ( Abpromise ... Synthetic peptide conjugated to KLH derived from ... ThPok. (Note: the amino acid sequence is ... ab23412 .) Entrez Gene ID: ...
Anti 7H6 Antigen (tight-junction associated protein Antigen) Monoclonal Antibody 7H6...
...
Biology Products: