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Quark Pharmaceuticals Announces Poster Presentations at RNAi Europe 2008
Date:9/17/2008

FREMONT, Calif., Sept. 17 /PRNewswire/ -- Quark Pharmaceuticals, Inc., a development-stage pharmaceutical company discovering and developing novel RNA interference (RNAi)-based therapeutics, today announced the presentation of posters at the 5th Annual RNAi Europe, taking place September 16-18, 2008 in Stockholm, Sweden. Three of Quark's scientists, Igor Mett, Hagar Kalinski, and Hagit Ashush, presented posters highlighting development of specific proprietary molecular tools facilitating target discovery, generation of potent RNAi therapeutics, and analysis of their activity and delivery in the framework of Quark's pre-clinical RNAi research.

A poster submitted by Hagar Kalinski is titled "Evaluation of siRNA Uptake in vivo in Target Tissues Using PCR-Based Quantification or in-situ Hybridization." It describes methods for analyzing spatial distribution of synthetic siRNA in target organs and tissues, including kidneys, lungs, retinas, and spinal cords, in an in vivo animal models. The quantification of siRNA delivery to target tissues and the ability to determine its cell-specific localization facilitates siRNA therapeutic development.

"Construction of Complex RNAi Libraries for Positive and Negative Phenotypic Selection of Target Genes," a poster submitted by Igor Mett, describes several of Quark's approaches to generating expressed RNAi libraries that are compatible with microarray-based positive and negative phenotypic cell selection. Part of the continuing development of Quark's BiFAR target discovery platform, these complex libraries can provide a high throughput tool to help identify targets for siRNA therapeutic development.

A third poster, submitted by Hagit Ashush, is titled "Tandem and RNAstar molecules for simultaneous silencing several genes," and evaluates the potential of complex dsRNA structures targeting two ("tandem") or three ("RNAstar") different genes in vitro. The multigene nature of pathogenesis for different diseas
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