Navigation Links
Quanterix Digital ELISA Measures Low Abundance Biomarkers of Inflammation in Crohn's Disease
Date:8/19/2011

CAMBRIDGE, Mass., Aug. 19, 2011 /PRNewswire/ -- Quanterix Corporation, a company enabling a new generation of molecular diagnostic tests based on its revolutionary Single Molecule Array (SiMoA) technology, today announced results of a pilot study to measure biomarkers of inflammation from patients with Crohn's disease.   The precise measurement of low abundance cytokines, which was possible using Quanterix's high sensitivity digital ELISA, allowed significant changes to be detected in patients before and after initiation of therapy.  The study was published online in the Journal of Immunological Methods.

"Quanterix's digital ELISA enabled physiologically relevant concentrations of two important cytokines, TNF-alpha and IL-6, to be measured in plasma from all patient samples tested.  Previous studies have not been able to quantify these biomarkers in all patients due to insufficient sensitivity," explained David Duffy, Ph.D., corresponding author of the study.  "The inherent sensitivity of this technology also made it possible, for the first time, to accurately quantify changes in protein levels during the course of anti-TNF-alpha therapy.  This work has important implications for patient management, including the ability to provide a quantitative index for how an individual is responding to therapy."

"Our collaboration with the Mayo Clinic is another example that highlights how unprecedented sensitivity enables important contributions to life science research and in vitro diagnostics," said Martin Madaus, Ph.D., Quanterix Executive Chairman.  "Although larger studies will be needed to fully understand the potential utility of cytokine measurements in the diagnosis of inflammatory diseases such as Crohn's, these results provide some indication of how sensitive and precise protein measurements enabled by SiMoA could be used clinically."

About Quanterix

Quanterix Corporation is developing its proprietary Single Molecule Array (SiMoA™) technology for the in vitro diagnostics and life science research markets. The digital nature of SiMoA yields unprecedented assay performance, stemming from a 1,000-fold improvement in sensitivity compared with today's analog only technology. SiMoA will enable researchers in life science to validate novel, low abundance biomolecules from a single droplet of blood, leading to greater insight into disease detection, diagnosis, therapy selection and disease monitoring. Automated systems based on SiMoA will provide diagnostic test information to healthcare practitioners faster, with greater reliability, unprecedented range and increased cost effectiveness.  Founded in 2007, the privately held Cambridge, Massachusetts-based company is backed by leading life science investors including ARCH Venture Partners, Bain Capital Ventures, and Flagship Ventures. For additional information, please visit www.quanterix.com.


'/>"/>
SOURCE Quanterix Corporation
Copyright©2010 PR Newswire.
All rights reserved

Related biology technology :

1. Quanterix and STRATEC Announce Strategic Partnership
2. Quanterix Announces Publication of Novel Method Expanding Single Molecule Detection Capability
3. Quanterix Announces New Technology Evaluation Agreement
4. Quanterix Corporation Announces the Addition of Dr. Robert Corn to its Scientific Advisory Board
5. COPAN Announces Workshop on Automated Specimen Processing, Digital Workup and Reporting in Microbiology During AACC Clinical Lab Expo
6. Volcano Announces the Introduction of the Eagle Eye® Platinum Digital IVUS Catheter at the 20th PCI Live Demonstration Course in Kurashiki
7. QuantaLife, Inc. Closes $17.2M Series B Financing to Accelerate Application Development for Its Droplet Digital™ PCR Platform and Establish Commercial Operations by 2011
8. Virginia Tech, Carilion team with physician to create digital ER pediatric response chart
9. QuantaLife Announces Launch of Droplet Digital™ PCR System
10. Skin & Allergy News Digital Network Launches Product Zone
11. Viscira Delivers Key Presentation to Pharmaceutical Marketing Professionals at Leading Digital Industry Conference
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/10/2016)... ANNAPOLIS, Md. , Feb. 10, 2016  The ... E. Busch , has announced that University of Maryland ... MD, PhD, MBA and University of Maryland Medical System ... recipients of the "Speaker,s Medallion," the highest honor given ... House of Delegates. Dean Reece and ...
(Date:2/10/2016)... -- ASAE is introducing a hybrid membership model which ... option of joining or renewing through an organizational purchasing ... size, every employee in any size association or AMC ... available member benefits.   John H. Graham, ... will allow organizations of any size and their employees ...
(Date:2/10/2016)... RICHLAND, Wash., Feb. 10, 2016  IsoRay, Inc. (NYSE ... seed brachytherapy and medical radioisotope applications for the treatment ... cancers, today announced its financial results for the second ... December 31, 2015. --> ... second quarter of fiscal 2016, which ended December 31, ...
(Date:2/10/2016)...  Matchbook, Inc., a company specializing in procurement ... announced today the appointment of Jim Shuman ... nearly 25 years of experience in supply chain, ... two decades in executive level roles as the ... and, most recently headed global logistics and procurement ...
Breaking Biology Technology:
(Date:2/4/2016)... , Feb. 4, 2016 The field ... one of the most popular hubs of the ... and other huge studies of human microbiota, have ... few years, the microbiome space has literally exploded ... research. This report focuses on biomedical aspects ...
(Date:2/3/2016)... 3, 2016 ... the "Emotion Detection and Recognition Market ... Others), Software Tools (Facial Expression, Voice Recognition ... Regions - Global forecast to 2020" ... http://www.researchandmarkets.com/research/d8zjcd/emotion_detection ) has announced the addition ...
(Date:2/2/2016)... YORK , Feb. 2, 2016 Technology Enhancements ... presents an analysis of the digital and computed radiography ... Malaysia , and Indonesia ... trends and market size, as well as regional market ... country and discusses market penetration and market attractiveness, both ...
Breaking Biology News(10 mins):