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QSB Anti-Virulence Platform Inhibits Biofilm Formation by Staphylococcus Aureus MRSA and Candida sp
Date:2/7/2008

detrimental effects of biofilms", said Dr. Heiri Gugger, CEO of QuoNova. "We continue to believe that our QSB platform is a breakthrough technology with wide applicability."

Notes to Editors:

About QuoNova LLC

QuoNova was founded in December 2006 and is the fifth portfolio company of XL TechGroup. QuoNova produces safe, efficacious, anti-virulence agents in the global fight against infection and damage caused by microbial biofilms. QuoNova's business strategy is to develop and commercialize its proprietary Quorum Sensing Blocker ("QSB") platform and introduce a disruptive paradigm of "smart microbial control". QuoNova is targeting multiple multi-billion dollar markets including therapeutics, medical devices, consumer care, agriculture and several industrial applications.

Micro-organisms use chemical signal molecules to communicate and recognize population density (Quorum Sensing) in order to organize their social behaviour, and co-ordinate the production of virulence factors, such as the release of toxins and biofilm formation. Biofilms are complex matrices produced by colonies of micro-organisms, and are very difficult to eradicate as they protect themselves against the immune system or conventional treatments such as antibiotics or biocides. In the healthcare environment they contribute significantly to complications in lung disease and wound healing, to medical device-associated infections as well as to dental plaque and contact lens-associated infection. In the home and in industrial processes they are a major cause of contamination, corrosion and efficiency reductions.

QuoNova's QSB technology disrupts microbial communication systems and by so doing inhibits toxin production, prevents biofilm formation and promotes degradation of already established biofilms. Moreover, research to date indicates that QuoNova's QSB compounds are non-toxic and safe. QSB molecules employ an anti-virulence approach and do not kill micro-organisms
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SOURCE QuoNova LLC
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Reacts with MBP from human, bovine and rat, epitope 129-138. Reacts weakly with rabbit. Does not react with guinea pig....
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