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QIAGEN and Max Planck Institute for Infection Biology Collaborate to Develop Assay for Active TB Risk in Individuals With Latent Infection
Date:1/9/2012

ecular reflex assay, which is based on significant research conducted at the MPIIB in Berlin, is expected to be a PCR-based test targeting multiple biomarkers. It will be designed to run on the QIAsymphony modular automation platform and to serve as a reflex test following QIAGEN's QuantiFERON-TB Gold test, the modern gold standard for detection of latent TB. The kits are not expected to be available before 2013 and will be commercialized by QIAGEN.

During TB infection, changes occur in the transcriptional profiles of immune cells circulating through blood - alterations in gene expression that reflect the body's immune response and help to distinguish between latent and active disease. The goal of QIAGEN's collaboration with the MPIIB is to format the most suitable markers from the sets of biomarkers identified by the institute into a molecular assay that can predict susceptibility or resistance to active TB disease in individuals with latent TB.

Both collaborators will cooperate in collecting, analyzing and evaluating data to identify genetic markers that indicate later development of active TB. QIAGEN will be responsible for assay design and manufacturing, while MPIIB will offer access to its marker sets and develop new biosignatures.

 "We are excited to collaborate with the MPIIB to jointly create an innovative and advanced prevention tool against the global TB threat," said Dr. James Rothel, Vice President, Head of Scientific Affairs, at QIAGEN. "These assays are highly complementary to our QuantiFERON technology. We believe that the combination of 'pre-molecular' and DNA-/RNA-based molecular testing technologies is the next-generation solution for screening and identifying infected individuals before they develop active TB disease. This initiative has the potential to reduce the spread of infectious diseases significantly and also to generate cost savings by treating individuals before development of active TB. The collaboration with t
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