Navigation Links
Putting a bull's-eye on the flu: Detailing influenza's structure for drug targeting
Date:10/21/2010

Beating the flu is already tough, but it has become even harder in recent years the influenza A virus has mutated so that two antiviral drugs don't slow it down anymore.

Reporting their findings in the journal Science, researchers from Florida State and Brigham Young move closer to understanding why not, and how future treatments can defeat the nasty bug no matter how it changes.

The two drugs, amantadine and rimantadine, are no longer recommended by the CDC for use against flu.

They used to work by blocking a hole in the influenza A virus called the "M2 channel," which plays a key role in the virus's ability to reproduce. When the channel changed ever so slightly at the atomic level, the virus became resistant to the drugs.

The research team used a 16-ton magnet to give the virus what amounts to an MRI, and they determined the tiniest, heretofore unknown details of the structure of this channel. The next step is to find a new way to block it.

"This work is laying a foundation to understand how that mutation does its damage and then of course how we can respond with a new bullet," said David Busath, a biophysicist at BYU and co-author of the paper. "Now we've got a fine enough resolution on the target we can start shooting at it, so to speak."

All versions of the flu virus have an M2 channel, so that makes it an attractive potential "Achilles' heel" drugs can aim for.

Another appeal of the channel as a drug target is that there are only a limited number of ways it could mutate in the future and continue to function. So it's possible that blockers could be identified in advance to defeat the virus no matter how it changes.

Because the channel's parts are so minute they cannot be seen with even an electron microscope, the researchers rely on a 15-foot-tall battery of electromagnets super-cooled by liquid nitrogen, supervised by Timothy A. Cross, a Florida State scientist and se
'/>"/>

Contact: Joseph Hadfield
joseph_hadfield@byu.edu
801-422-9206
Brigham Young University
Source:Eurekalert  

Page: 1 2

Related biology technology :

1. Researchers putting a freeze on oscillator vibrations
2. Putting the squeeze on an old material could lead to instant on electronic memory
3. Putting a new spin on current research
4. Intricate, curving 3-D nanostructures created using capillary action forces
5. New computer-tomography method visualizes nano-structure of bones
6. High-speed filter uses electrified nanostructures to purify water at low cost
7. Federal grant invests in nanostructured super materials
8. Unprecedented look at oxide interfaces reveals unexpected structures on atomic scale
9. Empa grows sea urchin-shaped structures
10. Depth charge: Using atomic force microscopy to study subsurface structures
11. Researchers use X-ray diffraction microscope to reveal 3-D internal structure of whole cell
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Putting a bull's-eye on the flu: Detailing influenza's structure for drug targeting
(Date:8/26/2015)... (PRWEB) , ... August 26, 2015 , ... ... Solutions, announces today that a second US laboratory is to open in Manhattan, ... with the continued partnership and long-term growth of research and development through collaboration ...
(Date:8/26/2015)... Aug. 26, 2015  Platform therapeutic company Symic ... received a $1.5M Phase II SBIR grant from ... develop its therapeutic agent to reduce arteriovenous fistula ... end stage renal disease (ESRD) patients undergoing hemodialysis. ... of Diabetes and Digestive and Kidney Diseases (NIDDK), ...
(Date:8/26/2015)... SPRINGS, Florida , August 26, 2015 /PRNewswire/ ... of the biggest factors fueling the optimism in ... approvals, M&A,s, collaborations and life sciences advancements.  Active ... developments are Pressure BioSciences, Inc. (OTCQB: PBIO), Sequenom, ... (NASDAQ: SRPT ), Raptor Pharmaceutical Corp. (NASDAQ: ...
(Date:8/25/2015)... ... August 25, 2015 , ... Vets Plus, Inc. recently ... The company has added a AS16 Sharples centrifuge to harvest products after fermentation. ... or fungal fermentation process development. , The new centrifuge greatly expands production ...
Breaking Biology Technology:MediVet Biologics Animal Health Secures Additional Laboratory Facility in Manhattan, Kansas 2MediVet Biologics Animal Health Secures Additional Laboratory Facility in Manhattan, Kansas 3Symic Biomedical Awarded $1.5MM NIH Phase II SBIR Grant to Develop its Proteoglycan Mimetic Therapeutics to Reduce Vascular Access Failures in ESRD 2Symic Biomedical Awarded $1.5MM NIH Phase II SBIR Grant to Develop its Proteoglycan Mimetic Therapeutics to Reduce Vascular Access Failures in ESRD 3New Collaborations & Mergers For Research of Molecular Biomarkers in Human Diseases & Clinical Trials for Cancer Therapies Fueling Growth in Multi-Billion Dollar Life Sciences Market 2New Collaborations & Mergers For Research of Molecular Biomarkers in Human Diseases & Clinical Trials for Cancer Therapies Fueling Growth in Multi-Billion Dollar Life Sciences Market 3New Collaborations & Mergers For Research of Molecular Biomarkers in Human Diseases & Clinical Trials for Cancer Therapies Fueling Growth in Multi-Billion Dollar Life Sciences Market 4New Collaborations & Mergers For Research of Molecular Biomarkers in Human Diseases & Clinical Trials for Cancer Therapies Fueling Growth in Multi-Billion Dollar Life Sciences Market 5New Collaborations & Mergers For Research of Molecular Biomarkers in Human Diseases & Clinical Trials for Cancer Therapies Fueling Growth in Multi-Billion Dollar Life Sciences Market 6New Collaborations & Mergers For Research of Molecular Biomarkers in Human Diseases & Clinical Trials for Cancer Therapies Fueling Growth in Multi-Billion Dollar Life Sciences Market 7New centrifuge and fermentor expand product development capacity at Vets Plus 2
... and macromolecular science at Case Western Reserve University, and ... optical imaging of anisotropic fluids such as liquid crystals, ... techniques. A research paper detailing the team,s findings appeared ... . , The molecules of these fluids, such as ...
... Guidance to $245 Million to $247 Million -, Third Quarter 2008 Highlights:, ... third quarter of 2007 -- Total revenues without Osteocel of $62.5 ... 2007, -- Gross profit of $54.7 million; up 73.2% from ... compared to 82.0% in the third quarter of 2007, -- ...
... Dynamic Alert Limited,(OTC Bulletin Board: DYMC) (the "Company") ... of medical cannabis-based,pharmaceutical products. Today the Company is ... acquire all of the assets of Cannex, a ... and political,activist Steven W. Kubby (http://www.kubby.com ). ...
Cached Biology Technology:Case Western Reserve University researcher improves LCDs with 3-D nanoimaging process 2Case Western Reserve University researcher improves LCDs with 3-D nanoimaging process 3Nuvasive Reports Third Quarter 2008 Financial Results 2Nuvasive Reports Third Quarter 2008 Financial Results 3Nuvasive Reports Third Quarter 2008 Financial Results 4Nuvasive Reports Third Quarter 2008 Financial Results 5Nuvasive Reports Third Quarter 2008 Financial Results 6Nuvasive Reports Third Quarter 2008 Financial Results 7Nuvasive Reports Third Quarter 2008 Financial Results 8Nuvasive Reports Third Quarter 2008 Financial Results 9Nuvasive Reports Third Quarter 2008 Financial Results 10Nuvasive Reports Third Quarter 2008 Financial Results 11Nuvasive Reports Third Quarter 2008 Financial Results 12Dynamic Signs Asset Acquisition Deal With Cannex and Brings Onboard Leading Medical Cannabis Research Scientist Dr. Robert Melamede, Former Chairman of the Biology Department, University of Colorado 2Dynamic Signs Asset Acquisition Deal With Cannex and Brings Onboard Leading Medical Cannabis Research Scientist Dr. Robert Melamede, Former Chairman of the Biology Department, University of Colorado 3
(Date:8/17/2015)... -- NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or the ... mobile commerce market and creator of the Wocket® smart ... The new marketing campaign is being spearheaded by an ... ( http://amplitudemarketing.com/ ) and TPMG ( http://tmpg.com/ ). ... driven marketing and brand awareness and has a client ...
(Date:8/11/2015)... -- Today, ZUK announced its Android smartphone Z1, featuring ... revenues in 2015 that relate to sales of FPC1155 for this ... 2,200 MSEK for 2015. Jörgen Lantto, CEO of FPC, ... smartphone manufacturer in China and we ... 155 for Z1 , ...
(Date:8/6/2015)... Calif. , Aug. 6, 2015 ... developer of human interface solutions, today announced collaboration ... technologies on Windows 10. Microsoft leveraged Synaptics, deep ... the operating system. Through stringent ... are fully certified with Microsoft,s Precision TouchPad (PTP) ...
Breaking Biology News(10 mins):NXT-ID, Inc. Launches Sales Campaign for Wocket Smart Wallet with Award Winning Marketing Team 2NXT-ID, Inc. Launches Sales Campaign for Wocket Smart Wallet with Award Winning Marketing Team 3FPC's Touch Fingerprint Sensor FPC1155 in ZUK's Smartphone Z1 2Synaptics Chosen for Human Interface Co-Development on Windows 10 2
... plots in the Northeast and Midwestern United States contain at ... study found. The study across two dozen states from North ... the landscape where invasive plants might take root. "We ... forest inventory had at least one introduced species, but this ...
... related in composition to the active ingredient in marijuana may ... the Journal of Leukocyte Biology shows ... in white blood cells, specifically macrophages, appear to weaken HIV-1 ... which the pharmaceutical properties of cannabis are manifested. Diminishing ...
... the remains of a recent lottery winner having been exhumed ... wonder what they can do to avoid the same fate. ... involving zebrafish suggests that riboflavin, also known as vitamin ... In addition, the report shows that zebrafish are a viable ...
Cached Biology News:In the Northeast, forests with entirely native flora are not the norm 2Synthetic derivatives of THC may weaken HIV-1 infection to enhance antiviral therapies 2Zebrafish study suggests that vitamin B2 (riboflavin) is an antidote to cyanide poisoning 2
See product name for description....
... excluding l-[U-14C]methionine, 1.85 MBq, 50 uCi. ... > 1.85 GBq/mg atom carbon, ... Mixture of Ala, Arg, Asp, Glu, ... Pro, Ser, Thr, Tyr and Val.1.85 ...
Request Info...
The Proteome Profiler Human Phospho-MAPK Array Kit contains 4 membranes - each spotted in duplicate with 23 different MAPK antibodies....
Biology Products: