Navigation Links
Putting a bull's-eye on the flu: Detailing influenza's structure for drug targeting
Date:10/21/2010

Beating the flu is already tough, but it has become even harder in recent years the influenza A virus has mutated so that two antiviral drugs don't slow it down anymore.

Reporting their findings in the journal Science, researchers from Florida State and Brigham Young move closer to understanding why not, and how future treatments can defeat the nasty bug no matter how it changes.

The two drugs, amantadine and rimantadine, are no longer recommended by the CDC for use against flu.

They used to work by blocking a hole in the influenza A virus called the "M2 channel," which plays a key role in the virus's ability to reproduce. When the channel changed ever so slightly at the atomic level, the virus became resistant to the drugs.

The research team used a 16-ton magnet to give the virus what amounts to an MRI, and they determined the tiniest, heretofore unknown details of the structure of this channel. The next step is to find a new way to block it.

"This work is laying a foundation to understand how that mutation does its damage and then of course how we can respond with a new bullet," said David Busath, a biophysicist at BYU and co-author of the paper. "Now we've got a fine enough resolution on the target we can start shooting at it, so to speak."

All versions of the flu virus have an M2 channel, so that makes it an attractive potential "Achilles' heel" drugs can aim for.

Another appeal of the channel as a drug target is that there are only a limited number of ways it could mutate in the future and continue to function. So it's possible that blockers could be identified in advance to defeat the virus no matter how it changes.

Because the channel's parts are so minute they cannot be seen with even an electron microscope, the researchers rely on a 15-foot-tall battery of electromagnets super-cooled by liquid nitrogen, supervised by Timothy A. Cross, a Florida State scientist and se
'/>"/>

Contact: Joseph Hadfield
joseph_hadfield@byu.edu
801-422-9206
Brigham Young University
Source:Eurekalert  

Page: 1 2

Related biology technology :

1. Researchers putting a freeze on oscillator vibrations
2. Putting the squeeze on an old material could lead to instant on electronic memory
3. Putting a new spin on current research
4. Intricate, curving 3-D nanostructures created using capillary action forces
5. New computer-tomography method visualizes nano-structure of bones
6. High-speed filter uses electrified nanostructures to purify water at low cost
7. Federal grant invests in nanostructured super materials
8. Unprecedented look at oxide interfaces reveals unexpected structures on atomic scale
9. Empa grows sea urchin-shaped structures
10. Depth charge: Using atomic force microscopy to study subsurface structures
11. Researchers use X-ray diffraction microscope to reveal 3-D internal structure of whole cell
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Putting a bull's-eye on the flu: Detailing influenza's structure for drug targeting
(Date:9/15/2014)... Hydro Dynamics, Inc. (HDI) of Rome, ... will be partnering with Proteaf Technologies (Proteaf) of ... implementing its Shock Wave Power Reactor (SPR) cavitation ... flow chemistry through process intensification has been widely ... for decades. The continuous chemistry has been ...
(Date:9/13/2014)... PA (PRWEB) September 13, 2014 Boehringer ... device innovations, is proud to announce the successful broadcast ... Network bariatric surgeons Leonardo Claros, MD, FACS, FAMBS, and ... 3Dâ„¢ Sleeve Gastrectomy Calibration System. , This sleeve ... postgraduate course of more than four hundred surgeons from ...
(Date:9/12/2014)... 12, 2014 Research and Markets ... Film Photoresist Industry Report 2014" report to their ... Industry Report 2014 is a professional and in-depth study ... photoresist industry . The report provides a ... and industry chain structure. The dry film photoresist market ...
(Date:9/11/2014)... MD (PRWEB) September 12, 2014 ... (LIMS), radio-frequency identification (RFID) solutions and sample management ... 5.1. , RURO completed work on the most ... August and it has already seen mass adoption, ... major release of version 5.0 brought an entirely ...
Breaking Biology Technology:Hydro Dynamics Partners with the Continuous Flow Chemistry Experts of Proteaf Technologies 2Boehringer Laboratories, Inc. Announces Live Surgery Using Innovative System to Calibrate Sleeve Gastrectomy 2Global Dry Film Photoresist Industry Report 2014 2Limfinity® Version 5.1 Available 2
... , DURHAM, N.C., Aug. 12 Oxygen Biotherapeutics, Inc. (OTC Bulletin ... 10-K for the fiscal year ended April 30, 2009. In addition to being available ... v , the 10-K can be downloaded from the company website at ... the Investors page. , , For the year ended April 30, ...
... , , LYNBROOK, N.Y., Aug. 12 ... company developing first in class collagenase-based products, today announced its ... , , "We were very pleased ... with Priority Review for XIAFLEX(TM) for the treatment of Dupuytren,s ...
... , , SAN DIEGO, Aug. 12 ... results for the three and six months ended June 30, 2009. , ... have the capital to complete and submit a New Drug Application (NDA) ... said Brian M. Culley, Principal Executive Officer at ADVENTRX. "Our financial ...
Cached Biology Technology:Oxygen Biotherapeutics, Inc. Files 10-K for Fiscal Year Ended April 30, 2009 2Oxygen Biotherapeutics, Inc. Files 10-K for Fiscal Year Ended April 30, 2009 3BioSpecifics Technologies Corp. Reports Second Quarter 2009 Financial Results 2BioSpecifics Technologies Corp. Reports Second Quarter 2009 Financial Results 3BioSpecifics Technologies Corp. Reports Second Quarter 2009 Financial Results 4BioSpecifics Technologies Corp. Reports Second Quarter 2009 Financial Results 5BioSpecifics Technologies Corp. Reports Second Quarter 2009 Financial Results 6ADVENTRX Pharmaceuticals Reports Second Quarter Financial Results 2ADVENTRX Pharmaceuticals Reports Second Quarter Financial Results 3ADVENTRX Pharmaceuticals Reports Second Quarter Financial Results 4ADVENTRX Pharmaceuticals Reports Second Quarter Financial Results 5ADVENTRX Pharmaceuticals Reports Second Quarter Financial Results 6ADVENTRX Pharmaceuticals Reports Second Quarter Financial Results 7
(Date:9/15/2014)... week,s print issue of the journal Science ... New Mexico, Montana and even the Netherlands, thanks to ... more the norm in these connected times. Yes, the ... produce innovations in biology, medicine, biotechnology and agriculture. It ... talked with that one, that one knew another one, ...
(Date:9/15/2014)... leading coral reef ecologists fears that reef biodiversity may ... that we once thought. , In an international study ... of Excellence for Coral Reef Studies (Coral CoE) says ... species within reef ecosystems. , In coral reefs, just ... that keep the ecosystem safe and functioning. , ...
(Date:9/15/2014)... new strategic vision document, released today by the ... the long-term goals, objectives, and strategies for the ... over the next five years (2015-2020). In ... activities, to be funded in 2015, will include ... fellowships. , The $500 million, 30-year program ...
Breaking Biology News(10 mins):Collaboration drives achievement in protein structure research 2Specialized species critical for reefs 2NAS Gulf Research Program announces strategic vision, initial opportunities 2NAS Gulf Research Program announces strategic vision, initial opportunities 3NAS Gulf Research Program announces strategic vision, initial opportunities 4
... , , , , , , , ... , , , ... file available on request).,This noisy frog is a potent... , Click here for more ... , , , , , , ...
... with obese children shows that all diets are effective in ... one that accounts for how many carbs are in the ... glucose levels may be most promising. The Cincinnati ... and portion-controlled diets with obese children is published online in ...
... team has identified epigenetic signatures, markers on DNA that ... cells. These signatures can predict the expression of a ... stem cells (iPSCs), cells that take on embryonic stem ... is controlled brings us one step closer to developing ...
Cached Biology News:Common North American frog identified as carrier of deadly amphibian disease 2Common North American frog identified as carrier of deadly amphibian disease 3Common North American frog identified as carrier of deadly amphibian disease 4New study compares diets for weight management in obese children 2Epigenetic signatures direct the repair potential of reprogrammed cells 2
Identify and characterize Phosphoinositide (PI(3,4,5)P3) binding...
Mouse monoclonal antibody to RNase L...
Compact, portable device, seals 96 and 384 well plates with preset temperature optimised for Eppendorf heat sealing foils and films. Suitable for plates of different heights. AC input: 50/60 Hz230 V...
... Caliper is proud to work in ... Automation Certified 25mm syringe filters in a ... filters are licensed for use on the ... Detailed Specifications and Pricing for our Automation ...
Biology Products: