Navigation Links
Pusan National University Announces Science Translational Medicine Publication Highlighting Landmark Demonstration of Functional Anti-Cancer Antibody Induction in Patients Following JX-594 Treatment
Date:5/23/2013

BUSAN, South Korea, May 23, 2013 /PRNewswire/ -- Pusan National University Yangsan Hospital, in collaboration with SillaJen, Inc., a private biotherapeutics and contract research company focused on research and development of targeted biological products for cancer, announced today a publication reporting the induction of functional anti-cancer antibodies in patients treated with the oncolytic and immunotherapeutic vaccinia JX-594 (pexastimogene devacirepvec; Jennerex Inc.).

This research was published in the May 15th, 2013 issue of the journal Science Translational Medicine. The co-senior and co-corresponding authors were Dr. Tae-Ho Hwang (Director of the Pusan National University Yangsan Hospital Clinical Research Center; SillaJen Chief Scientific Officer) and Dr. David Kirn (Jennerex founder and Advisor to SillaJen). The authors reported data from patients treated with JX-594 on Phase 1 and 2 clinical trials, as well as from rabbit tumor model studies. The authors demonstrated functional anti-cancer immunity induction, specifically including antibody-mediated complement-dependent cytotoxicity (CDC) in patients' serum targeting cancer cells.  Phase 1 data showed a correlation between patients' survival duration and a measure of CDC intensity. No autoimmune toxicities were reported in treated patients, including long-term survivors.

"This research was led by the laboratory group at SillaJen and Pusan National University, working closely with scientists at Jennerex. These findings, published in the premier research journal Science Translational Medicine, represent a landmark for the field of oncolytic immunotherapies for cancer," said Dr. Tae-Ho Hwang . "We were able to demonstrate for the first time that functional immune responses were induced against cancer cells following JX-594 treatment. T
'/>"/>

SOURCE Pusan National University
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3

Related biology technology :

1. First Evidence that Adipose Stem Cell-Based Critical Limb Ischemia Treatment is Safe & Effective is published in Circulation Journal by Lead Investigator Dr. Han Cheol Lee of Pusan National University
2. UV Flu Technologies Expands Its International Footprint
3. Elsevier Supports International Crisis Aid Through Pillars of Hope Campaign
4. International Attendance for Networking and Education at Informex Beyond Manufacturing
5. Sundberg Kicks Off National Expansion With Openings of New Headquarters, Logistically Centric Mega Warehouses
6. Leading Investigator to Present Clinical Data on Generex Oral-lyn™ at International Diabetes Federation Meetings in Dubai
7. Experts Launch the Alliance for Fertility Preservation at the International Society for Fertility Preservations 2nd World Congress
8. First Free-Standing International Mesothelioma Research Laboratory Opens in Los Angeles
9. Cord Blood America Announces Exclusive Agreement With National Childrens Leukemia Foundation to Store Stem Cells
10. PAREXEL International to Present at J.P. Morgan Healthcare Conference
11. DFH Pharma to Collaborate With National Cancer Institute to Develop Second-Generation HIV Maturation Inhibitor Drugs
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/15/2014)... 2014 The Microcompetition with Foreign DNA ... disease. One of these latent viruses is the Epstein ... rheumatoid arthritis (RA). Rheumatoid arthritis (RA) is a chronic ... by the theory, a study found that RA patients ... (1). , What is Microcompetition? , Dr. Hanan ...
(Date:1/15/2014)... Sunnyvale, CA (PRWEB) January 15, 2014 ... of high throughput research solutions, today announced that ... companies, has received delivery of Freeslate’s CM ... form screening. , Lupin, headquartered in Mumbai, ... quality, affordable generic and branded formulations and Active ...
(Date:1/14/2014)... (PRWEB) January 14, 2014 Date: Friday, ... p.m. , Location: Warrington Country Club, 1360 Almshouse Road, ... Foundation, the only national nonprofit organization solely dedicated to ... quality of life for those affected worldwide, will host ... Warrington Country Club in Warrington, Pa. , Each ...
(Date:1/14/2014)... , Jan. 14, 2014  3D Communications, a leading provider ... major scientific, regulatory, business, and media events in ... , today announced its former associate Virginia Cox , ... office. Virginia Cox re-joins ... Commissioner for the Office of External Affairs at the U.S. ...
Breaking Biology Technology:Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 2Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 3Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 2Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 3Hepatitis B Foundation to Host Annual Crystal Ball Gala 2Former FDA Associate Commissioner Returns To 3D Communications 2
... MINRAD International, Inc. (Amex: BUF ), announced ... or 50 positions. , , ... have taken this difficult, but necessary action to reduce our ... current adverse financial condition as we discussed in our recently ...
... To VisualSonics to Enable Molecular Imaging ... in the Pursuit of Neurology, Regenerative Medicine, Inflammation, and, ... , TORONTO and SAN ANTONIO, TX, Nov. ... announced the official signing of a licensing agreement providing ...
... Colo., Nov. 20 MicroPhage, Inc., http://www.microphage.com , today ... brings total capital raised to $11 million. Investors ... investors. All funds to,date have come from private ... will apply proceeds of its financing to complete the ...
Cached Biology Technology:MINRAD International, Inc. Announces Reduction in Workforce 2VisualSonics and Seno Medical Instruments Sign Exclusive Opto-Accoustic Licensing Agreement for Preclinical Research 2VisualSonics and Seno Medical Instruments Sign Exclusive Opto-Accoustic Licensing Agreement for Preclinical Research 3MicroPhage Closes Latest Financing 2
(Date:4/16/2014)... Geoscientists from the north-central U.S. and beyond will convene ... new science, expand on existing science, and explore the ... a special emphasis on applied geology, paleontology, and mid-continent ... on Thursday by Dr. Kirk Johnson, Sant Director of ... The meeting is hosted by the University of Nebraska-Lincoln. ...
(Date:4/16/2014)... do all of our movements, thoughts and feelings ... another, and recent studies have suggested that some of ... cells known as astrocytes may be listening in on, ... a new mouse study suggests that astrocytes might only ... when the neurons get really excited about something. This ...
(Date:4/16/2014)... RICHLAND, Wash. Geologic and soil processes are to ... throughout Ohio, according to a study published recently in ... analysis of 842 soil samples from all corners of ... than the screening level of concern recommended by the ... the public, say the authors, who note that regulatory ...
Breaking Biology News(10 mins):Walking with mammoths and exploring mid-continental geology 2Walking with mammoths and exploring mid-continental geology 3Walking with mammoths and exploring mid-continental geology 4Eavesdropping on brain cell chatter 2Eavesdropping on brain cell chatter 3Significant baseline levels of arsenic found in Ohio soils are due to natural processes 2Significant baseline levels of arsenic found in Ohio soils are due to natural processes 3Significant baseline levels of arsenic found in Ohio soils are due to natural processes 4
... thought that land plants evolved from stonewort-like algae. However, new ... Evolutionary Biology shows that the closest relatives to land ... Ancestors of green plants began to colonise the land ... that they evolved from streptophyte algae (a group of green, ...
... Researchers at The University of Western Ontario have discovered a ... vessels in tissues that are starved of oxygen. Dr. ... Medicine & Dentistry developed a strategy in which a biological ... the same time that the body is making its own ...
... Whether you,re talking about genes, or neurons, or the workings ... a matter of proteins. So understanding what protein complexes look ... out what makes cells tick. By harnessing the unique properties ... technique that can help deduce the orientation of specific proteins ...
Cached Biology News:Ancestors of land plants revealed 2Successful strategy developed to regenerate blood vessels 2Polarized microscopy technique shows new details of how proteins are arranged 2Polarized microscopy technique shows new details of how proteins are arranged 3
... to the maintenance of appropriate levels ... important and diverse as those involved ... stress response, antigen presentation, modulation of ... cell cycle regulation, transcription, and signalling ...
... protein identification Service includes 1. Scanning ... spots 3. High-sensitive tryptic in-gel digestion ... samples for MALDI-MS 5. Acquisition of ... MALDI-MS (Bruker ultraflex TOF/TOF) 6. Acquisition ...
Each Yeast-GFP clone represents an individual S. cerevisiae strain containing an open reading frame with a C-terminal Aequorea Victoria GFP (S65T) fusion tag....
... is a new product number, created ... If showing no availability yet, please ... (R4276) or contact customer service for ... surface, easy grip) Mfr ...
Biology Products: