Navigation Links
Puma Biotechnology Announces Positive PB272 (Neratinib) Phase II Data at CTRC-AACR San Antonio Breast Cancer Symposium
Date:12/9/2011

d grade 3/4 diarrhea.  No patients in the neratinib arm of the trial and 14% of the patients in the lapatinib/capecitabine combination arm of the trial experienced grade 3/4 PPE.  The diarrhea with neratinib was reported to be transient and manageable with antidiarrheal medications. The efficacy results from the trial showed that for the 117 patients in the neratinib monotherapy arm of the trial, 2% of the patients experienced a complete response, 27% of the patients experienced a partial response and 15% of the patients experienced stable disease for greater than 6 months, which translates to an overall response rate of 29% and a clinical benefit rate of 44%.  For the 116 patients in the trial treated with the combination of lapatinib and capecitabine, 4% of the patients experienced a complete response, 36% of the patients experienced a partial response and 23% of the patients experienced stable disease for greater than 6 months, which translates to an overall response rate of 40% and a clinical benefit rate of 63%.  The median progression free survival (PFS) for patients in the neratinib monotherapy arm was 4.5 months and the median PFS for the patients who had received the combination of lapatinib and capecitabine was 6.8 months. 

Combined Inhibition of mTORC1 with Temsirolimus and HER2 with Neratinib:
A Phase I/II Study in Patients with Metastatic HER2-Amplified or Triple-Negative Breast Cancer

The Phase I/II clinical trial of PB272 given in combination with the chemotherapy drug temsirolimus was conducted at Memorial Sloan-Kettering Cancer Center.  The trial was sponsored by Pfizer and the Phase I results of this trial were previously presented last year.  The Phase II portion of the study, presented at this symposium, enrolled patients with either HER2+ metastatic breast cancer and disease progression on trastuzumab or with triple negative breast cancer.  Patients in the study received
'/>"/>

SOURCE Puma Biotechnology, Inc.
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6

Related biology technology :

1. The European Union Signs Grant Contract to Fund a 2 Million Euro Biotechnology Research Project Led by Hadassah College Jerusalem
2. Animal Biotechnology - Technologies, Markets and Companies
3. Puma Biotechnology Announces Completion of Private Placement
4. HUYA Bioscience International Builds Long-Term Relationship with Shenzhen Polytechnic School of Applied Chemistry and Biotechnology
5. Congressman Eric Cantor and Health Diagnostic Laboratory, Inc. Discuss Job Growth at Virginia BioTechnology Research Park
6. Industrial Biotechnology China News 1109 - Annual Subscription
7. Nanobiotechnology: Applications and Global Markets
8. Californias Industrial Biotechnology Workforce: Creating Jobs and Leading Innovation
9. Global Biotechnology Instrumentation Industry
10. Separation Systems for Commercial Biotechnology
11. TWi Biotechnology Successfully Completes Patient Recruitment for Phase IIb Trial of AC-201 for the Treatment of Type II Diabetes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/14/2014)... AUSTIN, Texas , Jan. 14, 2014 ... analyze and research medicinal plants and therapeutic derivatives ... industry, health professionals, and researchers about the challenges ... (Logo: http://photos.prnewswire.com/prnh/20100430/DC95601LOGO ) The ...
(Date:1/14/2014)... January 14, 2014 iLab Solutions, the leader ... the new Director of Product Strategy. In this role, Michelle ... iLab sub-teams to guide in the development of iLab products. ... the maximum possible benefit to the scientific community by offering ...
(Date:1/14/2014)... Jan. 14, 2014  RXi Pharmaceuticals Corporation (OTCQX: RXII), ... commercializing innovative therapies addressing major unmet medical needs ... the Notice of Allowance from the United States ... RNAi compounds (sd-rxRNA®), for the treatment of fibrosis. ...
(Date:1/14/2014)... ®, provider of RapidResponse ®, a cloud-based supply chain ... S&OP ) service, is proud to be a gold sponsor ... at the Hilton San Diego Bayfront, January 30 – 31, ... , Director of Supply Chain at Amgen, as she presents ...
Breaking Biology Technology:World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 2World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 3World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 4World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 5World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 6World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 7World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 8iLab Solutions Announces Michelle Detwiler as the New Director of Product Strategy 2RXi Pharmaceuticals Receives US Notice of Allowance for a Key Patent Relating to its Self-Delivering Technology with sd-rxRNAs targeting CTGF, including RXI-109, for the Treatment of Fibrotic Disorders 2RXi Pharmaceuticals Receives US Notice of Allowance for a Key Patent Relating to its Self-Delivering Technology with sd-rxRNAs targeting CTGF, including RXI-109, for the Treatment of Fibrotic Disorders 3Event Alert: Kinaxis Customer to Present at the Biomanufacturing Summit "Supply Chain: Improving Network Effectiveness" 2
... , which has promised Milwaukee that it can provide citywide ... reprieve by the Milwaukee Common Council after falling ... give Midwest Fiber until June 7 to hook up the ... The company was to have the area hooked up by ...
... this, about half of all Americans required to do so are scurrying ... in Sunday's Arizona Republic . For a lot of folks like ... back by two days this year, was indeed upon us. And we'd ... of tax laws changed this year. , ,The realization that Tax Day ...
... stuff of legends. Sit in any presentation by one ... PowerPoint slide you'll likely be convinced that the methodology ... itself, and eventually bring about world peace in our ... unique and special. When they are questioned about the ...
Cached Biology Technology:Turbo Tax Online can teach new Web concepts a business lesson 2Turbo Tax Online can teach new Web concepts a business lesson 3With tech implementations, it's NOT the methodology, stupid 2With tech implementations, it's NOT the methodology, stupid 3
(Date:4/23/2014)... and German . ... the difference between sexes depends on one single element of the ... the two sexual chromosomes are X and Y, whereas women have ... the morphological and physiological differences between males and females. , But ... ago, the X and Y were identical, until the Y started ...
(Date:4/23/2014)... is available in French and Spanish ... 23 April 2014Today, the CEC released its Conservation Assessment ... Approach to Conservation, which identifies 29 priority conservation areas ... includes 11 different protected areas in the states of ... diverse arid and semi-arid habitats inhabited by rare and ...
(Date:4/23/2014)... People who have had a stroke, often suffer motor ... a study conducted in Taiwan, that will be published ... but is currently freely available on-line as an unedited ... when one group of stroke victims had their own ... brain and a similar group did not, those who ...
Breaking Biology News(10 mins):Male or female? 2Male or female? 3Conservation priorities released for several protected areas along US-Mexico border 2Conservation priorities released for several protected areas along US-Mexico border 3Autologous stem cell therapy improves motor function in chronic stroke victims 2
... YORK (Feb. 28, 2013) The Democratic Republic of ... Okapi Faunal Reserve (OFR), has declined by 37 percent in ... according to wildlife surveys by WCS and DRC officials. ... DRC continues unabated, the species could be nearly extinguished from ...
... source of great controversyparticularly in Europebut acts of vandalism ... the health and ecological impacts of those crops hard ... for use in GM crop studies could serve as ... crop biotechnology, according to an article published in ...
... 2,778 bees while retracing the muddy steps of a scientist ... than a century ago. Occasionally stung, but considering herself ... guided her field work, the Montana State University ecologist and ... ." "It,s exciting," Burkle said as the Feb. 28 ...
Cached Biology News:Elephants are vanishing from DRC's best-run reserve 2Elephants are vanishing from DRC's best-run reserve 3Elephants are vanishing from DRC's best-run reserve 4Fighting GM crop vandalism with a government-protected research site 2Old records, new bees result in 'Science' paper for MSU ecologist 2Old records, new bees result in 'Science' paper for MSU ecologist 3
... Novagen's HT96 Isothermal Block is an ... hold HT96 plates and to provide efficient ... plate. This new design of the HT96 ... offers an enhanced product design allowing for ...
Umbilical cord blood neutrophils, For immunohistochemistry (IHC)...
...
Adjustable tilt angle 0 to 20 Adjustable speed of 3-25 RPM Load capacity: 2.7 kg (6 lbs.) Ambient temperature range 4C to 65C Low voltage power is supplied by wall mount transformer...
Biology Products: