Navigation Links
Pulmonary fibrosis: Between a ROCK and a hard place
Date:2/22/2013

Pulmonary fibrosis is a scarring or thickening of the lungs that causes shortness of breath, a dry cough, fatigue, chest discomfort, weight loss, a decrease in the ability of the lungs to transmit oxygen to the blood stream, and, eventually, heart failure. Cells known as myofibroblasts normally secrete materials that are required for wound healing; once the wound has closed, the cells disappear. In pulmonary fibrosis, the myofibroblasts stick around, continuing to secrete wound healing factors that cause fibrosis in the lungs. In this issue of the Journal of Clinical Investigation, Yong Zhou and colleagues at the University of Alabama at Birmingham identified a mechanosensitive cellular signaling pathway in myofibroblasts that is activated by the hardening of tissue that has become fibrotic. Activation of this pathway promotes myofibroblast survival and prevents the normal disappearance of these cells after completion of wound healing. The pathway is dependent on a protein known as ROCK. Zhou and colleagues found that a drug that inhibits ROCK, fasudil, attenuates the pro-survival pathway and causes myofibroblasts to die. Further, fasudil treatment protected mice from injury-induced lung fibrosis. These studies suggest that ROCK inhibitors could be used to treat pulmonary fibrosis. In a companion Attending Physician article, Dean Sheppard of the University of California, San Francisco, discusses the feasibility of using ROCK inhibitors in a clinical setting.


'/>"/>

Contact: Jillian Hurst
press_releases@the-jci.org
Journal of Clinical Investigation
Source:Eurekalert

Page: 1

Related biology technology :

1. Intravenous Remodulin Approved for the Treatment of Pulmonary Arterial Hypertension in Most of the European Union
2. Ikaria® Completes Patient Enrollment in Pivotal Phase III Trial for Bronchopulmonary Dysplasia
3. Innovative MetaMorph® NX Software Shatters Barriers Between Researchers and Image Analysis Goals with Exclusive Visual Workflow
4. EveryDayMatters.com Aims to Raise Awareness and Coordinate Care Between Mental and Physical Health
5. Researchers Find Potential Link Between Drinking Alcohol And Breast Cancer
6. Collaboration between Sanofi and Joslin Diabetes Center to focus on new drugs for diabetes
7. Triboelectric generator produces electricity by harnessing friction between surfaces
8. Blue Brain Project accurately predicts connections between neurons
9. Mangrove Partners Agrees to Support Amended Transaction Between Nabi Biopharmaceuticals and Biota Holdings
10. Puma Biotechnology Announces Completion of Private Placement
11. Unigenes 2011 Year in Review - Key Elements in Place to Address Debt in 2012
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/15/2014)... Scottsdale, Arizona (PRWEB) January 15, 2014 ... innovation and growth for Scottsdale’s Brain State Technologies®. ... team at Wake Forest University Medical Center who ... Susanne Marcus Collins Foundation, had research papers published ... Amy Grant highlighted Brainwave Optimization® in First for ...
(Date:1/15/2014)... (PRWEB) January 15, 2014 AudioNotch ... an experimental new therapy for the treatment of tinnitus. ... for their unique tinnitus frequency, and over a period ... AudioNotch has previously provided Notched Sound Therapy in two ... is pleased to announce to release of a new ...
(Date:1/14/2014)... Date: Friday, April 11, 2014 , ... Country Club, 1360 Almshouse Road, Warrington, Pa. ... nonprofit organization solely dedicated to finding a cure for ... those affected worldwide, will host its annual Crystal Ball ... Warrington, Pa. , Each year, the Crystal Ball ...
(Date:1/14/2014)... Diego, CA (PRWEB) January 14, 2014 ... solutions based on the products of cells grown ... have entered into an international license agreement with ... Histogen’s proprietary multipotent cell conditioned media (CCM). ... the existing license between Histogen and Suneva Medical, ...
Breaking Biology Technology:Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 2Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 3Hepatitis B Foundation to Host Annual Crystal Ball Gala 2Histogen and Suneva Medical Expand License for Cell Conditioned Media-based Aesthetic Products Internationally 2Histogen and Suneva Medical Expand License for Cell Conditioned Media-based Aesthetic Products Internationally 3
... ... of Chronic Wounds, ... focused on improving patient quality of life, today,announced that its ... KFH Novo medical device, a breakthrough medical,technology that enhances the ...
... 11 Anadys Pharmaceuticals,Inc. (Nasdaq: ANDS ) announced ... 28th Annual Healthcare Conference on Tuesday, March 18, 2008 ... being held at the Boston,Marriot Copley Place., Steve ... Inc., will present an overview of Anadys and its ...
... 11 Nile Therapeutics,Inc. (OTC Bulletin Board: NILT), today ... financial results for 2007 after the market,closes on Thursday, ... and live webcast to discuss these financial results and ... 4:30 p.m. ET, 1:30 p.m. PT,that afternoon., Interested ...
Cached Biology Technology:Kingfisher Healthcare Receives European CE Mark for Next Generation Wound Healing Device 2Anadys Pharmaceuticals to Present at the Cowen and Company Healthcare Conference 2Nile Therapeutics to Announce 2007 Fourth Quarter and Full Year Financial Results on Thursday, March 13, 2008 2
(Date:4/15/2014)... Puerto Rican community is creating a tropical home away ... has caught the attention of scientists. David W. Taylor ... Connecticut) took a close look at the fresh crops ... evidence that gives new meaning to a phrase that ... in the kitchen. , "Culinary preferences tell us a ...
(Date:4/15/2014)... University of Missouri researchers have previously shown that a ... exercise exists. In a new study, Frank Booth, a ... found a potential link between the genetic pre-disposition for ... which mental maturation occurs. , For his study, Booth ... activity or extreme laziness. Booth then put the rats ...
(Date:4/15/2014)... Case Western Reserve University dental researchers have found ... immune cells from the mouth to study how ... inflammation. , By isolating some specialized immune cells ... how they fight diseases in the mouthor reject ... hope to learn more about treating and preventing ...
Breaking Biology News(10 mins):The human food connection: A new study reveals more about our relationship to food 2The human food connection: A new study reveals more about our relationship to food 3Genetic pre-disposition toward exercise and mental development may be linked 2New method isolates immune cells for researchers to study how they ward off oral diseases 2
... been named as one of the 2008 Environmental Scientists ... His half-brother, biologist Jules Blais, is the other winner ... prestigious in the environmental sciences. The prize recognizes the ... Smol is series editor of the Springer ...
... 2 BIO-key International,Inc. (OTC Bulletin Board: BKYI), ... identification solutions, today announced that it,has been awarded ... with a large multi-national technology company. BIO-key will,license ... be used on,multiple, large international and domestic opportunities., ...
... WI, JUNE 2, 2008-- An understanding how environmental ... transport and fate of agricultural chemicals in the ... degradation of surface and ground waters from past, ... has been conducted at field or smaller scales, ...
Cached Biology News:BIO-key(R) Awarded $2 Million Biometric Contract by Multi-National Company 2Holistic understanding: Ag chemicals in the environment 2
Intestinal Epithelium Differentiation Environment...
...
The Programmable MP-5000P-F Power Supply can be applied for any Microfluidic application....
... Drummond Scientific has a long and ... microinjection apparatus. Several years ago we ... displacement microdispenser was being modified to ... unit by redesigning the microdispenser to ...
Biology Products: