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Publication of Supplementary Prospectus
Date:4/29/2008

d May, One Bunhill Row, London EC1Y 8YY.

- This announcement is an advertisement and not a prospectus and investors should not subscribe for or purchase any securities referred to in this announcement except on the basis of information contained in the prospectus and the supplementary prospectus published by shire limited in connection with the proposed scheme. The prospectus was published on 16 April 2008 and made available on shire's website and is available for inspection at the UK listing authority's document viewing facility. The supplementary prospectus has been published today and will be made available on shire's website and is available for inspection at the uk listing authority's document viewing facility.

Notes to editors

Shire PLC

Shire's strategic goal is to become the leading specialty biopharmaceutical company that focuses on meeting the needs of the specialist physician. Shire focuses its business on attention deficit and hyperactivity disorder (ADHD), human genetic therapies (HGT), gastrointestinal (GI) and renal diseases. The structure is sufficiently flexible to allow Shire to target new therapeutic areas to the extent opportunities arise through acquisitions. Shire's in-licensing, merger and acquisition efforts are focused on products in niche markets with strong intellectual property protection either in the US or Europe. Shire believes that a carefully selected portfolio of products with strategically aligned and relatively small-scale sales forces will deliver strong results.

For further information on Shire, please visit the Company's website: http://www.shire.com.

This announcement does not constitute an offer or invitation to purchase securities.

Terms used but not defined herein have the meanings given to them in the Prospectus.

Morgan Stanley & Co International plc is acting for Shire and Shire Limited and no one else in connection wit
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