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Publication of Shire plc's Annual Report 2008
Date:3/25/2009

y tax resident in Ireland, is designed to help protect Shire's tax position. - During Q3 2008 Shire acquired a majority voting interest in Jerini and published an Offer Document in respect of acquiring the remaining shares in Jerini that it did not already own. By December 31, 2008 Shire had acquired over 98% of the shares in Jerini. The acquisition has added Jerini's HAE product, FIRAZYR, to the portfolio. - In November 2008 Shire settled all pending litigation brought by certain former dissenting shareholders of TKT. As a result of this settlement, Shire paid the former dissenting shareholders the same price of $37 per share originally offered to all TKT shareholders at the time of the 2005 merger, plus interest. The settlement represents a total payment of $568 million, comprising consideration at $37 per share of $420 million and an interest cost of $148 million.

Results of operations for the years to December 31, 2008 and 2007

For the year to December 31, 2008 the Group's total revenues increased by 24% to $3,022.2 million, compared to $2,436.3 million in 2007. Net income for the year to December 31, 2008 was $156.0 million compared to a net loss of $1,451.8 million in 2007.

Total revenues

    The following table provides an analysis of the Group's total revenues by
source:

    Year to December 31,                             2008       2007   Chan
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SOURCE Shire Plc
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