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Publication of Shire plc's Annual Report 2008
Date:3/25/2009

d scientific personnel from other companies, academic institutions, government entities and other organizations. It may not be able to successfully attract and retain such personnel. The Group has agreements with a number of its key scientific and management personnel for periods of one year or less. The loss of such personnel, or the inability to attract and retain the additional, highly skilled employees required for its activities could have an adverse effect on the Group's business.

2. Business Review

Chief Executive Officer's review

Risks-wisely measured and judiciously taken-are part and parcel of every successful company, and certainly we've taken our fair share at Shire. In our brightest moments we have stood at a critical juncture, made defining, not-always-obvious decisions, and redefined the future not just for ourselves, but for the physicians and patients we serve.

Since succeeding Matt Emmens as Chief Executive Officer ('CEO') in June, I have been particularly keen on staying true to those aspects of our culture that brought us to our present state as one of the most effective biopharmaceutical companies in the world: the willingness to take measured risks; the courage to challenge one another; and the unyielding commitment to the patients, physicians, and communities we serve. We spent the time, in 2008, to look around and to project forward-to set the targets that will enable us to emerge, by 2015, as one of the most valuable specialty biopharmaceutical companies in the world. We committed to the underlying thesis that now forms the core of our corporate brand -that we strive to be as brave as the people we help.

Of course, achieving our mission demands quite a lot of Shire's pipeline as well as its marketed portfolio, and I am very pleased with the steps that we have taken to further leverage both. Consider this: over the course of the last two years alone,
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SOURCE Shire Plc
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