Publication of Shire plc's Annual R...( DUBLIN March 25 /- Shire plc (LSE...)

DUBLIN, March 25 /PRNewswire-FirstCall/ -- Shire plc (LSE: SHP, NASDAQ: SHPGY), the global specialty biopharmaceutical company, announces that its Annual Report and Accounts in respect of the year ended December 31, 2008 has been published on its website. Shire has previously announced unaudited full year 2008 results, prepared in accordance with US generally accepted accounting principles, in its full year earnings announcement on February 19, 2009.

Copies of the Annual Report and Accounts, Notice of Annual General Meeting and Proxy Card will be submitted to the UK Listing Authority on or about March 27, 2009 and will shortly thereafter be available for inspection at the UK Listing Authority's Document Viewing Facility, which is situated at:

    Financial Services Authority
    25 The North Colonnade
    Canary Wharf
    London
    E14 5HS

    Tel: +44-(0)20-7066-1000

    Copies of the Annual Report and Accounts may also be obtained from:

    The Company Secretary's Office

    Shire plc

    Hampshire International Business Park
    Chineham, Basingstoke
    Hampshire RG24 8EP
    United Kingdom

In accordance with the requirements of Rule 4.1 of the Disclosure and Transparency Rules which applies in respect of accounting periods commencing after January 20, 2007, Appendix to this announcement contains a description of principal risks and uncertainties, business review for the year ended December 31, 2008 and the directors' responsibility statement.

    Tony Guthrie
    Deputy Company Secretary
    Notes to Editors
    SHIRE PLC

Shire's strategic goal is to become the leading specialty biopharmaceutical company that focuses on meeting the needs of the specialist physician. Shire focuses its business on attention deficit hyperactivity disorder (ADHD
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