Navigation Links
Publication in Neuropsychopharmacology Confirms CeNeRx's Novel RIMA Antidepressant TriRima(TM) Selectively and Reversibly Inhibits MAO-A
Date:12/7/2009

RESEARCH TRIANGLE PARK, N.C., Dec. 7 /PRNewswire/ -- CeNeRx BioPharma, Inc., a clinical stage company developing innovative treatments for diseases of the central nervous system, today announced that a newly published PET imaging study in human subjects confirms that CeNeRx's novel compound TriRima(TM) reversibly inhibits MAO-A (monoamine oxidase A), an enzyme in the brain that plays a key role in the regulation of mood. TriRima is a member of a new class of selective and reversible inhibitors of MAO-A known as RIMAs, and it is the first whose mechanism has been validated in human brain imaging studies.

In this Cooperative Research and Development Agreement (CRADA) study, funded by CeNeRx BioPharma, Inc. and published in the journal Neuropsychopharmacology(1), researchers led by Dr. Joanna Fowler of the Brookhaven National Laboratory used PET (positron emission tomography) imaging techniques to assess the degree and reversibility of TriRima's inhibition of brain MAO-A in 15 non-depressed men. TriRima blood plasma levels after oral administration were also measured.

The researchers reported that TriRima produced a robust dose-related inhibition of brain MAO-A at two hours after administration and that brain MAO-A recovered completely by 24 hours post-dosing, demonstrating TriRima's excellent reversibility. In addition, they found that the plasma concentration of TriRima was highly correlated with the degree of inhibition of brain MAO-A. These two findings make TriRima the first agent in the RIMA class with documented reversible inhibition of human brain MAO-A. In addition, because the degree of MAO-A inhibition was closely correlated with observed plasma levels, the authors concluded that the study validates the use of plasma TriRima concentrations as a surrogate marker for brain MAO-A inhibition and support the use of this relations
'/>"/>

SOURCE CeNeRx BioPharma, Inc.
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related biology technology :

1. Dendreon Announces Publication of Phase 1 Study Highlighting Immunologic and Clinical Activity of Lapuleucel-T (Neuvenge(R)) in Advanced Breast Cancer Patients
2. Nventa announces publication of HspE7 data
3. Amarin Announces Publication of Pre-Clinical Memory Data in Journal of Neurochemistry
4. Industry Executives Finding Value in Shift of Scientific Publications
5. ThromboGenics and BioInvent Announce Publication of Exciting Data on a Novel Class of Angiogenesis Inhibitors in Cell
6. Kendle Named Best CRO for Second Consecutive Year by Leading Global Pharmaceutical Publication Scrip
7. Research by Case Western Reserve University, VA earns cover of prestigious science publication
8. Oncolytics Biotech Inc. Announces Publication of Research on Combination Reovirus and Cyclophosphamide Treatment
9. BioTrends Releases Fourth Annual Nephrology TreatmentTrends Publication Highlighting Market Trends for Renal Anemia, Hyperphosphatemia, and Secondary Hyperparathyroidism
10. Oncolytics Biotech Inc. Announces Publication of Research on Combination Reovirus and Radiation Therapy
11. Ortho Biotech Statement On JAMA Publication Regarding Erythropoiesis-Stimulating Agents
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2014)... Mass. , July 30, 2014 /PRNewswire/ ... ), a biotechnology company focused on discovering, ... unmet medical needs using RNA-targeted technologies, today ... (RXI-109-1402) with RXI-109, for the reduction of ... revision surgery, has been initiated. ...
(Date:7/30/2014)... San Diego, CA (PRWEB) July 30, 2014 ... second contract from the U.S. Environmental Protection Agency ... company’s expertise in developmental toxicity models, including tests ... on neuron formation and the formation of connections ... function. Inhibition of neurodifferentiation and synapse formation by ...
(Date:7/30/2014)... LayerBio, Inc., an MIT spinoff developing ... round of seed financing from friends and family investors. ... develop a novel sustained-release product for ophthalmology. , "We ... their commitment to this important work," said Dr. Ken ... of many areas in which innovations in drug delivery ...
(Date:7/29/2014)... of significant technological challenges in their quest to ... for the James Webb Space Telescope. , The ... scientist at NASA,s Goddard Space Flight Center in ... arrays that is, those activated by applying ... the current technology,s magnetically activated arrays. This advance ...
Breaking Biology Technology:RXi Pharmaceuticals Expands Clinical Program with Initiation of Third Phase 2a Study with RXI-109 for Treatment of Hypertrophic Scars 2RXi Pharmaceuticals Expands Clinical Program with Initiation of Third Phase 2a Study with RXI-109 for Treatment of Hypertrophic Scars 3RXi Pharmaceuticals Expands Clinical Program with Initiation of Third Phase 2a Study with RXI-109 for Treatment of Hypertrophic Scars 4RXi Pharmaceuticals Expands Clinical Program with Initiation of Third Phase 2a Study with RXI-109 for Treatment of Hypertrophic Scars 5U.S. Environmental Protection Agency (EPA) Awards Vala Sciences a Second ToxCast Contract 2U.S. Environmental Protection Agency (EPA) Awards Vala Sciences a Second ToxCast Contract 3Revolutionary microshutter technology hurdles significant challenges 2Revolutionary microshutter technology hurdles significant challenges 3Revolutionary microshutter technology hurdles significant challenges 4
... molecule famous for storing the genetic blueprints for all ... a new paper,* researchers at the National Institute of ... of DNA can be used to purify the highly ... carbon nanotubes are needed to make "quantum wires" for ...
... 2011 HumanTouch, LLC announced that it has ... by the U.S. General Services Administration. 8(a) STARS ... engineered to provide cutting-edge technology solutions from award-winning ... is designed to promote small business utilization when ...
... Inc. (NYSE Amex: CUR ) announced it ... develop its human neural stem cell technology for the ... "Research to Treat Cancerous Brain Tumors with Neural Stem ... Investigator John Zhang, MD, PhD, Professor of Neurosurgery, Loma ...
Cached Biology Technology:Armchair science: DNA strands that select nanotubes are first step to a practical 'quantum wire' 2HumanTouch Awarded 8(a) STARS II GWAC Contract 2Neuralstem Awarded Department of Defense Contract for Brain Cancer Research 2Neuralstem Awarded Department of Defense Contract for Brain Cancer Research 3
(Date:7/30/2014)... climate threaten some of the world,s most rare ... seed collections to save the seeds in banks ... genetic diversity., For decades, these seed collections have ... one-size-fits-all approach for how many seeds to gather, ... of species, pollination mode, growth habitat and population ...
(Date:7/30/2014)... humans figured out how to create colors, nature had ... wings of many different hues, for example. Now scientists ... environmentally friendly way to make colored plastics. Their paper ... of materials rather than dyes, to produce color ... , N. Asger Mortensen, Anders Kristensen and colleagues point ...
(Date:7/30/2014)... Scientists are searching through a massive collection of ... 50 years ago, and the effort is yielding fresh ... inhabited. , When the collection is fully curated, a ... the largest unbiased Dominican amber collection in the world, ... discovery thus far is that of a pygmy locust, ...
Breaking Biology News(10 mins):Saving seeds the right way can save the world's plants 2Decades-old amber collection offers new views of a lost world 2
... , Michelle S. Mazei-Robison, Erica Bowton, Marion Holy, ... Galli, and Randy D. Blakely Elevated dopamine ... forms of attention-deficit hyperactivity disorder (ADHD), according to ... form of dopamine transporter in two siblings with ...
... to maximise efficiency of movement through water; humans have ... century. So shouldn,t we be taking more notice ... the US have been doing just that. By ... dolphins, these scientists have discovered some features of their ...
... because the game was designed to make a lefty ... McDonnell Douglas Professor of Engineering at Washington University in ... a mechanical engineer who specializes in aircraft and helicopter ... Favorite Pastime. First of all, some numbers. "Ninety percent ...
Cached Biology News:News tips from the Journal of Neuroscience 2News tips from the Journal of Neuroscience 3Whales and dolphins influence new wind turbine design 2Baseball diamonds: the lefthander's best friend 2
Rabbit Anti-Human Secretory Carrier Membrane Protein 2 (SCAMP2 Polyclonal AntibodyOther Sub-Family: not assigned-Other Applications: Western Blot...
Parathyroid Hormone Receptor 2 [PTHR2]...
... a proprietary high-performance desalting resin, exclusive to ... characteristics compared to other commercially available resins. ... of protein can be processed, providing exceptional ... salts and other small molecules ( ...
... member of the caudal-related homeobox family, is ... proliferation and differentiation in intestinal epithelial cells. ... cells towards the phenotype of differentiated villus ... of the phenotype. Clone CDX2-88 reacts with ...
Biology Products: