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Publication in Neuropsychopharmacology Confirms CeNeRx's Novel RIMA Antidepressant TriRima(TM) Selectively and Reversibly Inhibits MAO-A
Date:12/7/2009

RESEARCH TRIANGLE PARK, N.C., Dec. 7 /PRNewswire/ -- CeNeRx BioPharma, Inc., a clinical stage company developing innovative treatments for diseases of the central nervous system, today announced that a newly published PET imaging study in human subjects confirms that CeNeRx's novel compound TriRima(TM) reversibly inhibits MAO-A (monoamine oxidase A), an enzyme in the brain that plays a key role in the regulation of mood. TriRima is a member of a new class of selective and reversible inhibitors of MAO-A known as RIMAs, and it is the first whose mechanism has been validated in human brain imaging studies.

In this Cooperative Research and Development Agreement (CRADA) study, funded by CeNeRx BioPharma, Inc. and published in the journal Neuropsychopharmacology(1), researchers led by Dr. Joanna Fowler of the Brookhaven National Laboratory used PET (positron emission tomography) imaging techniques to assess the degree and reversibility of TriRima's inhibition of brain MAO-A in 15 non-depressed men. TriRima blood plasma levels after oral administration were also measured.

The researchers reported that TriRima produced a robust dose-related inhibition of brain MAO-A at two hours after administration and that brain MAO-A recovered completely by 24 hours post-dosing, demonstrating TriRima's excellent reversibility. In addition, they found that the plasma concentration of TriRima was highly correlated with the degree of inhibition of brain MAO-A. These two findings make TriRima the first agent in the RIMA class with documented reversible inhibition of human brain MAO-A. In addition, because the degree of MAO-A inhibition was closely correlated with observed plasma levels, the authors concluded that the study validates the use of plasma TriRima concentrations as a surrogate marker for brain MAO-A inhibition and support the use of this relations
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SOURCE CeNeRx BioPharma, Inc.
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