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Publication in Clinical Cancer Research Confirms Ability of Peregrine's Bavituximab to Target Tumor Blood Vessels with Excellent Specificity
Date:3/3/2008

- Data Further Supports High Degree of Tumor Targeting Specificity for

Bavituximab, Currently in Phase II Cancer Trials in Combination with

Chemotherapy - - Imaging Study Also Suggests Potential Utility of Anti-PS Agents for

Molecular Imaging of Tumors -

TUSTIN, Calif., March 3 /PRNewswire-FirstCall/ -- Peregrine Pharmaceuticals, Inc. (Nasdaq: PPHM), a clinical stage biopharmaceutical company developing monoclonal antibodies for the treatment of cancer and hepatitis C virus infection, today reported publication of a new preclinical study in Clinical Cancer Research that supports the specific tumor targeting properties of the company's novel anti-phosphatidylserine (anti-PS) antibody platform. Peregrine's most advanced anti-PS monoclonal antibody, bavituximab, is currently in Phase II cancer trials in combination with chemotherapy.

The newly published study demonstrates that in a model of prostate cancer, bavituximab's phosphatidylserine target is specifically exposed in tumors, but not in normal tissues. When labeled with a radioisotope, bavituximab preferentially targeted the tumor blood vessels, strongly localizing to the tumors rather than normal organs. The study was conducted by Dr. Philip Thorpe and his colleagues at UT Southwestern Medical Center and is published in the March 1 issue of Clinical Cancer Research. It is the latest in a series of preclinical studies that have confirmed important elements of the mechanism of action of bavituximab.

"These results confirming the high specificity of bavituximab to target tumor blood vessels with little or no localization to normal tissues support the good safety profile and encouraging signs of anti-tum
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SOURCE Peregrine Pharmaceuticals, Inc.
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