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Proteolix's Carfilzomib Receives Orphan Drug Designation for Treatment of Multiple Myeloma
Date:4/2/2008

ing up in the marrow and crowding out healthy blood cells. The myeloma cells do not make effective antibodies and instead release abnormal proteins, called M proteins. M proteins can damage the immediate area and travel through the bloodstream and damage other parts of the body. Left untreated, multiple myeloma can cause bone damage, elevated blood calcium, anemia, and predisposition to infection and kidney damage. In 2007, there were an estimated 19,900 new cases diagnosed and 10,790 deaths due to multiple myeloma in the United States. For more information on multiple myeloma go to http://www.cancer.gov/cancertopics/types/myeloma.

About Waldenstrom's Macroglobulinemia

Waldenstrom's Macroglobulinemia (WM) is a slow-growing type of non-Hodgkin's lymphoma that starts in white blood cells called B lymphocytes. WM is also called lymphoplasmacytic lymphoma because it occurs when abnormal lymphoplasmacytic cells multiply out of control, producing large amounts of a protein called monoclonal immunoglobulin M. WM can result in enlargement of the liver and spleen due to anemia and large amounts of immunoglobulin M can lead to hyperviscosity syndrome, in which the blood becomes abnormally thick. Symptoms of this syndrome include visual problems such as blurring or loss of vision and neurological problems including headache, dizziness, or vertigo. WM is a rare cancer with only about 1,500 new cases diagnosed annually in the United States. For more information about WM, go to http://www.cancer.gov/cancertopics/factsheet/Sites-Types/WM.

About Proteolix

Proteolix, Inc. is a privately-held biopharmaceutical company, headquartered in South San Francisco, and dedicated to discovering, developing and commercializing pharmaceutical therapies that target certain cancers and immunological conditio
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SOURCE Proteolix, Inc.
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