Navigation Links
Protein from probiotic bacteria may alleviate inflammatory bowel disorders
Date:5/23/2011

ic stuff?" said Polk, co-author on the study and currently director the Saban Research Institute of Children's Hospital Los Angeles.

"Probiotic bacterial function is not very clear right now," said Yan, a research associate professor of Pediatrics at Vanderbilt.

Polk and Yan showed that LGG prevented epithelial cells from inflammation-induced apoptosis a kind of cell suicide. They then isolated and characterized two specific proteins secreted by LGG (which they called p75 and p40) responsible for the bacterium's beneficial effects.

In the current study, Yan investigated the mechanisms by which one of these proteins, p40, prevents and treats colitis.

In cell experiments, Yan and colleagues showed that p40 activates the epidermal growth factor receptor (EGFR), a protein critical for cell survival and growth. Activation of EGFR protected epithelial cells in two ways: by preventing both apoptosis and inflammation-induced disruption of the "tight junctions" between epithelial cells, which form a barrier to keep toxic substances and pathogens out of the bloodstream.

To test the isolated protein's effectiveness in animal models of disease, the investigators developed a gel bead system to deliver the protein specifically to the colon while protecting the protein from being degraded by stomach acid and digestive enzymes.

In three different mouse models of intestinal inflammation, they showed that p40 prevented and treated intestinal injury and acute colitis.

This study is one of the few to identify and use individual molecules from beneficial microbes as potential therapeutics. In clinical applications, Yan says that the isolated protein could provide at least two advantages to using whole bacteria.

"One is bioavailability," she said. "Even if you eat live bacteria (as in yogurt), that does not mean 100 percent of bacteria will still be alive (and active) in your body."

Another advant
'/>"/>

Contact: Craig Boerner
craig.boerner@vanderbilt.edu
615-322-4747
Vanderbilt University Medical Center
Source:Eurekalert

Page: 1 2 3

Related biology technology :

1. Protein Research Marketing Insights
2. Researchers write protein nanoarrays using a fountain pen and electric fields
3. LI-COR Introduces the Odyssey(R) Two-Color NIR Fluorescent Protein Molecular Weight Marker
4. Jellyfish Protein Shows Potential to Help With Memory
5. Scientists use light to control proteins
6. Protein-printing technique gives snapshots of immune system defense
7. Max Planck Institute of Biochemistry Uses MathWorks Tools in Its Quest to Cure Cancer : Institute Accelerates Reconstruction of Key Protein Complexes Using MATLAB and Parallel Computing Toolbox
8. Richter-Helm and Athera Biotechnologies Partner in Development of Recombinant Protein to Treat Cardiovascular Disease
9. Cell Biosciences Introduces Kits for Oncoprotein Analysis
10. DSM and Crucell Sign Agreement with Bioceros to Serve as Pre-Approved Cell Line Generation Partner of PER.C6(R) Cell Line Proteins
11. Max Muscle Introduces First-Ever Probiotics Protein Bar
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/2/2015)... 2015 German-based Moenninghoff has designated the ... for the Moenninghoff product line . ... to announce that the R.M. Hoffman Company will be ... founded in 1916, this is a strategically important step. ... kind of professional distributor we need to successfully grow ...
(Date:6/1/2015)... YONGIN, South Korea , June 1, ... Green Cross Biotherapeutics Inc. (GCBT) kicked off construction today ... the Montreal Technoparc,s Saint-Laurent Campus. The CA$315 million project ... in Canada in the biopharmaceutical ... intravenous immunoglobulin (IVIG) and albumin manufacturing plant in ...
(Date:6/1/2015)... HANOVER, N.J. , June 1, 2015 /PRNewswire/ ... II clinical study of CTL019, an investigational chimeric ... its potential in the treatment of specific types ... study conducted by the University of Pennsylvania,s Perelman ... or refractory (r/r) diffuse large B-cell lymphoma (DLBCL) ...
(Date:6/1/2015)... N.C. , June 1, 2015  Fennec ... presentation of positive interim results from a poster ... multi-centre open label randomised phase III trial of ... ototoxicity in patients receiving cisplatin (Cis) monotherapy for ... at the American Society of Clinical Oncology (ASCO) ...
Breaking Biology Technology:R.M. Hoffman Company designated official United States distributor for the Moenninghoff product line. 2R.M. Hoffman Company designated official United States distributor for the Moenninghoff product line. 3Green Cross Biotherapeutics Kicks Off Construction in Montreal 2Green Cross Biotherapeutics Kicks Off Construction in Montreal 3Novartis highlights CTL019 data showing its potential in the treatment of specific types of hard-to-treat non-Hodgkin lymphoma 2Novartis highlights CTL019 data showing its potential in the treatment of specific types of hard-to-treat non-Hodgkin lymphoma 3Novartis highlights CTL019 data showing its potential in the treatment of specific types of hard-to-treat non-Hodgkin lymphoma 4Novartis highlights CTL019 data showing its potential in the treatment of specific types of hard-to-treat non-Hodgkin lymphoma 5Novartis highlights CTL019 data showing its potential in the treatment of specific types of hard-to-treat non-Hodgkin lymphoma 6Fennec Announces Presentation Of Positive Interim Sodium Thiosulfate Phase III Safety Data At The 2015 ASCO Annual Meeting 2Fennec Announces Presentation Of Positive Interim Sodium Thiosulfate Phase III Safety Data At The 2015 ASCO Annual Meeting 3Fennec Announces Presentation Of Positive Interim Sodium Thiosulfate Phase III Safety Data At The 2015 ASCO Annual Meeting 4
... for 15 minutes, couldn't imagine the influence the Internet, blogging, social ... these tools, everyone can have their 15 minutes - but just ... is about all anyone has time for these days, at least ... reminded of this after coming back from a near three-week holiday ...
... the lead cancer drug candidate of Madison's Quintessence Biosciences ... Food and Drug Aministration for being tested on cancer ... meeting of the American Association for Cancer Research , ... scale and applied in safe doses, the company announced. , ...
... Madison, Wis . - Mithridion, Inc ., a biopharmaceutical ... of Alzheimer's disease, has closed an additional $1.2 million of ... , ,The latest round of funding brings the total equity ... above the company's initial funding target. Mithridion will use the ...
Cached Biology Technology:On the Web, attention spans shrink, the need for value rises 2On the Web, attention spans shrink, the need for value rises 3Quintessence Biosciences advances cancer drug 2Alzheimer's drug developer lands $1.2M in venture funding 2Alzheimer's drug developer lands $1.2M in venture funding 3
(Date:6/1/2015)... June 1, 2015 According to ... Sensing Market by Technology (Touch-based & Touchless), Application (Consumer ... & by Geography - Global Forecast to 2020", published ... is expected to reach $23.55 Billion by 2020, at ... Browse 83 market data T ables ...
(Date:6/1/2015)... 1, 2015 According to ... Market by Application (Government, Military & Defense, Healthcare, ... and Security), Technology (Face Recognition, Fingerprint Recognition, Iris ... Recognition, and Others), Function (Contact and Non-Contact) & ... Europe , APAC, Row) - Global ...
(Date:5/29/2015)... , May 28, 2015 Research ... addition of the "Facial Recognition Market by ... - Global Forecast to 2020" report to ... have seen facial recognition technology become more efficient ... to gain traction and investment from the commercial ...
Breaking Biology News(10 mins):Gesture Recognition & Touchless Sensing Market Worth $23.55 Billion by 2020 2Gesture Recognition & Touchless Sensing Market Worth $23.55 Billion by 2020 3Gesture Recognition & Touchless Sensing Market Worth $23.55 Billion by 2020 4Next Generation Biometrics Market Worth $24,448.84 Million by 2020 2Next Generation Biometrics Market Worth $24,448.84 Million by 2020 3Next Generation Biometrics Market Worth $24,448.84 Million by 2020 4Global advanced Facial Recognition Market Expected to Grow From $2.77 Billion in 2015 to $6.19 Billion in 2020, at an Estimated CAGR of 17.4% 2
... a remote region of the Russian mountains a previously unknown ... Lead Scientist Professor Hans Cornelissen and his Russian-Dutch team describe ... root belongs to the small alpine plant Corydalis conorhiza and ... through layers of snow. Given this novel behaviour, the scientists ...
... In a study published in the open-access, peer-reviewed ... Han and Piotr Jablonski at Seoul National University, Korea, ... their genitalia from males, forceful copulatory attempts, females of ... the evolutionary arms race between the sexes. Instead, females ...
... are acclaimed in representing natural climate archives. For ... of these annual rings depend mainly on temperature and ... seasonal variations, the correlation is not so evident. ... Geosciences and their colleagues of the Australian National University ...
Cached Biology News:Newly discovered snow roots are 'evolutionary phenomenon' 2Hidden genitalia in female water striders makes males 'sing' 2Australia's climate: Drought and flooding in annual rings of tropical trees 2
... to deparaffinize and perform Heat Induced Antigen ... sections mounted on glass microscope slides. Deparffinization ... the high temperature used in HIER (over ... paraffin by detergent. Formaldehyde fixation impairs or ...
... Serum; U.S. sourced, ideal for ... quality; Low hemoglobin; Endotoxin: < ... of US origin; U.S. sourced, ... an uncompromising quality. Low hemoglobin ...
Collected from animals of U.S. origin.Collected from animals of U.S. origin. *Can be used in cell growth studies and immunoassays. *Sterility tested, * Mycoplasma tested upon request, *Endoto...
...
Biology Products: