Navigation Links
Prostate cancer risk variant found to be in a functional DNA sequence linked with disease
Date:7/12/2010

ored the engineered DNA sequences in every cell of the animal. If a human enhancer interacts with the reporter gene in any tissue, the cells turn blue when treated with a stain.

"By looking at the transgenic mice we noticed that their prostate and mammary glands were blue," Nobrega noted, "indicating the presence of regulatory sequences within the piece of human DNA that we were testing." They then focused on the prostate, identifying the specific enhancer driving the observed expression pattern.

The group could then engineer a version of the enhancer that contained a risk variant associated with prostate cancer and test this in mice. The prostate enhancer harboring the risk allele in the sequence drove expression of the reporter gene significantly higher in the mouse prostate relative to the normal version of the enhancer.

"The fact that a single nucleotide difference so markedly altered the enhancer's activity within the context of a living organism clearly demonstrates the potential impact that variation within non-coding gene regulatory elements could have on disease state," Nobrega noted.

Previous research has indicated that this enhancer modifies activity of a nearby gene called MYC, a proto-oncogene that exhibits altered expression in prostate cancers. However, those studies found no correlation between the risk allele enhancer and MYC expression in normal or cancerous prostate tissues, suggesting altered MYC expression may not be the biological factor conferring risk to disease in these cases.

The authors further explained that the risk variant enhancer activity was observed in the prostate throughout organogenesis and development, suggesting that the cancer risk variant might assert its influence very early, long before a tumor forms. "This strengthens the notion of a pathogenic process that could initiate much earlier in life than the appearance of clinical alterations, one in which thi
'/>"/>

Contact: Peggy Calicchia
calicchi@cshl.edu
516-422-4012
Cold Spring Harbor Laboratory
Source:Eurekalert

Page: 1 2 3

Related biology technology :

1. Dendreon Initiates Second of Two New Phase 2 Trials of PROVENGE for Prostate Cancer
2. Revolutionary New In-Office EVOLVE(R) Laser Prostate Treatment Available Throughout Western Oregon
3. Orange Coast Urology Offers Advanced In-Office Patient EVOLVE(R) Laser Prostate Treatment
4. Exposure to Agent Orange linked to prostate cancer in Vietnam veterans
5. Poniard Announces Positive Incremental Efficacy and Safety Data From Ongoing Phase 2 Picoplatin Trial in Hormone-Refractory Prostate Cancer
6. Medivation Announces Presentation of 24-Week Clinical Data of MDV3100 in Castration-Resistant Prostate Cancer Patients
7. Cardiums InnerCool Announces New Tissue-Specific UroCool(TM) System for Use in Prostate Surgeries
8. Exposure to Agent Orange linked to prostate cancer in Vietnam veterans
9. OGX-011 Shows Overall Survival Advantage in Prostate Cancer Compared to Standard Therapy in a Randomized Phase 2 Study
10. Prostate Cancer Patient in Montpellier Becomes First Cancer Patient in France Treated with Varians RapidArc(TM) Radiotherapy
11. Cardiums InnerCool Announces First Patient Treated With New Tissue-Specific UroCool(TM) System in Robotic-Assisted Prostate Surgery Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/25/2015)... (PRWEB) March 25, 2015 Data ... Novel Mechanism of Action in Neuromuscular Diseases ... – Cytokinetics, Incorporated (Nasdaq: CYTK) announced the publication ... muscle troponin activator tirasemtiv in the journal Neurotherapeutics. ... IIa “Evidence of Effect” or hypothesis-generating clinical trial ...
(Date:3/25/2015)... the HAGUE, Netherlands , March 25, 2015 /PRNewswire/ ... therapy for chronic gastro-esophageal reflux disease (GERD) in the ... Surgery . 2015; 157(3):556-567 ], establishing the long ... The study included 25 patients with severe ... taking prescribed daily proton pump inhibitor (PPI) medication for ...
(Date:3/25/2015)... 25, 2015  18 piglets born recently are ... by scientists in the College of Agriculture and Natural ... breakthrough in the field of genetic engineering. Bhanu ... Animal & Avian Sciences (ANSC) and Ki-Eun Park, ... produced genome-edited pigs using a recently developed, groundbreaking ...
(Date:3/25/2015)...  CASI Pharmaceuticals, Inc. (Nasdaq: CASI ), a ... of innovative therapeutics addressing cancer and other unmet medical ... on China , announces that it ... therapy drug candidate ENMD-2076 in triple-negative breast cancer (TNBC) ... Sciences in Beijing , China.  ...
Breaking Biology Technology:Cytokinetics Announces Publication of Results from Phase II Trial of Tirasemtiv in Patients with Myasthenia Gravis 2Cytokinetics Announces Publication of Results from Phase II Trial of Tirasemtiv in Patients with Myasthenia Gravis 3Cytokinetics Announces Publication of Results from Phase II Trial of Tirasemtiv in Patients with Myasthenia Gravis 4Cytokinetics Announces Publication of Results from Phase II Trial of Tirasemtiv in Patients with Myasthenia Gravis 5Cytokinetics Announces Publication of Results from Phase II Trial of Tirasemtiv in Patients with Myasthenia Gravis 6EndoStim LES Stimulation therapy demonstrates long term safety and efficacy results in treating reflux patients 2EndoStim LES Stimulation therapy demonstrates long term safety and efficacy results in treating reflux patients 3University of Maryland Researchers Successfully Produce Genome-edited Pigs Using Revolutionary Technology 2CASI Pharmaceuticals Announces Initiation Of A Phase 2 Trial With ENMD-2076 In Triple-Negative Breast Cancer In China 2CASI Pharmaceuticals Announces Initiation Of A Phase 2 Trial With ENMD-2076 In Triple-Negative Breast Cancer In China 3CASI Pharmaceuticals Announces Initiation Of A Phase 2 Trial With ENMD-2076 In Triple-Negative Breast Cancer In China 4CASI Pharmaceuticals Announces Initiation Of A Phase 2 Trial With ENMD-2076 In Triple-Negative Breast Cancer In China 5
... June 24, 2011 /PRNewswire-Asia-FirstCall/ -- China Agri-Business, Inc. ... manufacturer and distributor of organic agricultural application products ... its Chinese operating subsidiary, Shaanxi Xinsheng Centennial Agriculture ... right to manage and operate Shaanxi Qinfeng Agrochemical ...
... - U.S. Department of Energy researchers have won 36 ... R&D Magazine for the most outstanding technology developments with ... annually in recognition of exceptional new products, processes, materials ... the market the previous year. "I want to ...
... 2011 BioNeutral Group Inc., (OTCBB: BONU.ob) today ... distribution phase of their revolutionary Cold Sterilant and ... BioNeutral was selected by New Jersey based T.U.C.S. ... service and distribution company, because of the superior ...
Cached Biology Technology:China Agri-Business Acquired Management and Operation Rights of Shaanxi Qinfeng Agrochemical Inc. in Xi'an, China 2China Agri-Business Acquired Management and Operation Rights of Shaanxi Qinfeng Agrochemical Inc. in Xi'an, China 3China Agri-Business Acquired Management and Operation Rights of Shaanxi Qinfeng Agrochemical Inc. in Xi'an, China 4Department of Energy projects win 36 R&D100 Awards for 2011 2Department of Energy projects win 36 R&D100 Awards for 2011 3Department of Energy projects win 36 R&D100 Awards for 2011 4Department of Energy projects win 36 R&D100 Awards for 2011 5Department of Energy projects win 36 R&D100 Awards for 2011 6Department of Energy projects win 36 R&D100 Awards for 2011 7Department of Energy projects win 36 R&D100 Awards for 2011 8Department of Energy projects win 36 R&D100 Awards for 2011 9BioNeutral Starts Commercial Deployment of Its Ygiene 206 Sterilant and Ogiene Products Within Port Authority Facilities Using T.U.C.S. Cleaning Services 2BioNeutral Starts Commercial Deployment of Its Ygiene 206 Sterilant and Ogiene Products Within Port Authority Facilities Using T.U.C.S. Cleaning Services 3BioNeutral Starts Commercial Deployment of Its Ygiene 206 Sterilant and Ogiene Products Within Port Authority Facilities Using T.U.C.S. Cleaning Services 4
(Date:3/11/2015)... , March 11, 2015   The ... its platform to scientifically measure and harness music ... to real-time biometrics and objective measurements of physiology, ... music at scale in large populations. It is ... technologists and clinicians perform rigorous studies and accelerate ...
(Date:3/10/2015)... OXFORD, Conn. , March 10, 2015 /PRNewswire/ ... NXTDW) ("NXT-ID" or the "Company"), a biometric authentication ... reports the company,s Wocket™ smart wallet has been ... 2015" by Rethink Modern. Rethink Modern ... sharing modern and innovative items for your home and lifestyle that ...
(Date:3/2/2015)... 2, 2015 Synaptics Inc. (NASDAQ: ... interface solutions, today announced a new implementation of ... enable rapid and secure transactions and reliable identification ... is a turnkey solution providing mouse and keyboard ... integrate fingerprint ID solutions into their product offerings, ...
Breaking Biology News(10 mins):Introducing The Sync Project, a Global Collaboration Harnessing the Scientific Potential of Music for Health 2Introducing The Sync Project, a Global Collaboration Harnessing the Scientific Potential of Music for Health 3NXT-ID's Wocket Smart Wallet Named Number One Best Tech Gift for 2015 by Rethink Modern 2NXT-ID's Wocket Smart Wallet Named Number One Best Tech Gift for 2015 by Rethink Modern 3NXT-ID's Wocket Smart Wallet Named Number One Best Tech Gift for 2015 by Rethink Modern 4Synaptics Unveils New Fingerprint ID Solution for Gamers 2Synaptics Unveils New Fingerprint ID Solution for Gamers 3
... carbon per year from wind erosion and dust storms affecting ... research.,Top soil is rich in nutrients and carbon but is ... Dawn, in Sydney in 2009. When wind lifts ... location of soil carbon. Some carbon falls ...
... Bowman, climate science communications expert and host of the Climate ... Peter Wadhams, two of the three authors of an article ... controversy since its release on July 24, 2013. The authors ... warming in the Arctic the release of methane from ...
... For a new study in the Journal of ... lipids affect growth performance in weaned pigs. The researchers ... According to the researchers, it is important to ... have improved over the years. Dr. Olayiwola Adeola, ...
Cached Biology News:Soil carbon 'blowing in the wind' 2Researchers re-evaluate swine nutrition 2
...
recombination at attR1 and attR2 sites...
... Peroxidase Conjugate, 2 ml. ... enzyme molecules for use ... situ hybridization applications.High specificity ... Labeling & Detection, Protein ...
Whole rabbit blood (any breed, either sex) is collected at the time of slaughter and processed immediately at 4C, bottled, frozen and stored at -70C....
Biology Products: