Navigation Links
Prostate cancer risk variant found to be in a functional DNA sequence linked with disease
Date:7/12/2010

ored the engineered DNA sequences in every cell of the animal. If a human enhancer interacts with the reporter gene in any tissue, the cells turn blue when treated with a stain.

"By looking at the transgenic mice we noticed that their prostate and mammary glands were blue," Nobrega noted, "indicating the presence of regulatory sequences within the piece of human DNA that we were testing." They then focused on the prostate, identifying the specific enhancer driving the observed expression pattern.

The group could then engineer a version of the enhancer that contained a risk variant associated with prostate cancer and test this in mice. The prostate enhancer harboring the risk allele in the sequence drove expression of the reporter gene significantly higher in the mouse prostate relative to the normal version of the enhancer.

"The fact that a single nucleotide difference so markedly altered the enhancer's activity within the context of a living organism clearly demonstrates the potential impact that variation within non-coding gene regulatory elements could have on disease state," Nobrega noted.

Previous research has indicated that this enhancer modifies activity of a nearby gene called MYC, a proto-oncogene that exhibits altered expression in prostate cancers. However, those studies found no correlation between the risk allele enhancer and MYC expression in normal or cancerous prostate tissues, suggesting altered MYC expression may not be the biological factor conferring risk to disease in these cases.

The authors further explained that the risk variant enhancer activity was observed in the prostate throughout organogenesis and development, suggesting that the cancer risk variant might assert its influence very early, long before a tumor forms. "This strengthens the notion of a pathogenic process that could initiate much earlier in life than the appearance of clinical alterations, one in which thi
'/>"/>

Contact: Peggy Calicchia
calicchi@cshl.edu
516-422-4012
Cold Spring Harbor Laboratory
Source:Eurekalert

Page: 1 2 3

Related biology technology :

1. Dendreon Initiates Second of Two New Phase 2 Trials of PROVENGE for Prostate Cancer
2. Revolutionary New In-Office EVOLVE(R) Laser Prostate Treatment Available Throughout Western Oregon
3. Orange Coast Urology Offers Advanced In-Office Patient EVOLVE(R) Laser Prostate Treatment
4. Exposure to Agent Orange linked to prostate cancer in Vietnam veterans
5. Poniard Announces Positive Incremental Efficacy and Safety Data From Ongoing Phase 2 Picoplatin Trial in Hormone-Refractory Prostate Cancer
6. Medivation Announces Presentation of 24-Week Clinical Data of MDV3100 in Castration-Resistant Prostate Cancer Patients
7. Cardiums InnerCool Announces New Tissue-Specific UroCool(TM) System for Use in Prostate Surgeries
8. Exposure to Agent Orange linked to prostate cancer in Vietnam veterans
9. OGX-011 Shows Overall Survival Advantage in Prostate Cancer Compared to Standard Therapy in a Randomized Phase 2 Study
10. Prostate Cancer Patient in Montpellier Becomes First Cancer Patient in France Treated with Varians RapidArc(TM) Radiotherapy
11. Cardiums InnerCool Announces First Patient Treated With New Tissue-Specific UroCool(TM) System in Robotic-Assisted Prostate Surgery Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... BOSTON , Jan. 22, 2015  Transwestern | RBJ today ... feet of office space for Shire a leading biopharmaceutical company, ... . Transwestern | RBJ,s Robert Richards , president, and ... the lease for the entire five-floor building at 95 Hayden ...
(Date:1/22/2015)... Mass (PRWEB) January 21, 2015 Cambridge Semantics, ... Web technology, today announced that 2014 was a record-breaking year ... the capabilities of the Anzo Smart Data Platform and our ... and utilize insights from diverse data which led to record ...
(Date:1/22/2015)... (PRWEB) January 22, 2015 Crystal Diagnostics (CDx) ... that it has received AOAC-PTM Certifications for the six non-O157 ... and O145; collectively referred to as STEC or the “Big-6”) ... colony forming unit (cfu) per 325 g of raw ground ...
(Date:1/22/2015)... Dr. Greg Leyer of UAS Labs recently ... Supplements Pre-Conference seminar on probiotics in San Diego, CA. ... education conference for health care professionals. This year’s pre-conference seminar ... probiotics in health. Dr. Leyer spoke about the emerging topics ...
Breaking Biology Technology:Transwestern | RBJ Advises Shire in 202,000 SF Lease, Creating Boston's Largest Suburban Biotech Campus 2Cambridge Semantics Announces Record Results for 2014 2Crystal Diagnostics Awarded AOAC-PTM Accreditation for the Rapid Detection of “Big 6” E.coli Food Pathogens 2
... Healthcare , a unit of General Electric Co. ... (EHR) has received certification for use in physician offices ... Information Technology . , ,CCHIT certification is considered the ... customers that products meet the functionality, interoperability, and security ...
... have been an educator in my life, but I am ... three years running an educational software company, so I wear ... educational software. , ,Having toiled in the belly of the ... made to get a product out the door, but I ...
... have a number of juicy topics I wanted to review ... biotech/medical device conference (BIOMED 2006), recent participation in meetings about ... happenings in Japan, and other research that has crossed my ... on why I originally wanted to start writing this column. ...
Cached Biology Technology:Judging educational software 2Judging educational software 3Judging educational software 4The world of in-vitro diagnostics is another Midwest success story 2The world of in-vitro diagnostics is another Midwest success story 3The world of in-vitro diagnostics is another Midwest success story 4The world of in-vitro diagnostics is another Midwest success story 5The world of in-vitro diagnostics is another Midwest success story 6
(Date:1/22/2015)... Jan. 22, 2015 Research and Markets ... the "Global Wearable Technologies Market and Applications, ... Trends and Forecast 2014-2020" report to their ... smart devices that can be worn on the ...
(Date:12/22/2014)... , Dec. 22, 2014 Research and Markets ... of the "The Global Watermarking and Fingerprinting ... http://photos.prnewswire.com/prnh/20130307/600769 This ... media watermarking and fingerprinting markets. Watermarking aims to ...
(Date:12/19/2014)... 18, 2014   LaunchKey , the first decentralized mobile ... Internet of Things era, today announced the close of ... was led by Metamorphic Ventures with participation from ENIAC ... and others.  LaunchKey has raised $4 million to date, ...
Breaking Biology News(10 mins):Global Wearable Technologies Market and Applications, Opportunities, Industry Analysis, Segmentation, Size, Growth, Share, Overview, Trends and Forecast 2014-2020 2The Global Watermarking and Fingerprinting Markets 2LaunchKey Raises $3 Million in Additional Funding Led by Metamorphic Ventures 2LaunchKey Raises $3 Million in Additional Funding Led by Metamorphic Ventures 3
... "organocatalyst" developed at Oregon State University is now available ... company, it should make new drug development around the ... This catalyst, named "Hua Cat," is also one ... a result of support from the University Venture Development ...
... The predictability and scale of seasonal changes in ... and whether the animals always travel together to the ... a paper published online in February in Global Ecology ... Institute researchers and partners. The study,s findings ...
... from the cellulosic biomass of perennial grasses and other,non-food ... highly touted as potential replacements for gasoline, diesel and ... fuels through the use of microbes. However, many of ... to microbes, which presents a "production versus survival" conundrum. ...
Cached Biology News:New organic catalyst should enhance drug research and development 2Smithsonian scientists report changes in vegetation determine how animals migrate 2Striking the right balance: JBEI researchers counteract biofuel toxicity in microbes 2Striking the right balance: JBEI researchers counteract biofuel toxicity in microbes 3
Antibodies were affinity purified using epitopes specific to JLP immobilized on solid support....
... Edited by N.C. Price ... detailed information on protein chemistry ... characterization of proteins. Data on ... Chromatography, crystalization, size determination, amino ...
... B.S. Dunbar (1994) • This ... principles and methods for preparing samples ... such as radiometric and bioluminescence-enhanced detection ... covered are, the detection and characterization ...
See product name for description....
Biology Products: