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Prometheus Strengthens Intellectual Property Portfolio with Newly Issued Patents for Thiopurine Metabolite Testing
Date:10/30/2008

SAN DIEGO, Oct. 30 /PRNewswire/ -- Prometheus Laboratories Inc., a specialty pharmaceutical and diagnostics company, announced that the U.S. Patent and Trademark Office (USPTO) has issued two separate patents covering the technology for PROMETHEUS(R) Thiopurine Metabolites, a diagnostic test that enables physicians to optimize ongoing dosing of thiopurines to reach and maintain desired therapeutic levels. The USPTO has approved the issuance of the claims in U.S. Patent Nos. 7,425,546 and 7,429,570, both entitled, "Methods of optimizing drug therapeutic efficacy for treatment of immune- mediated gastrointestinal disorders."

"We are pleased that the USPTO has acknowledged the validity of these patents and approved their issuance," said William Franzblau, Vice President of Legal Affairs for Prometheus. "This is another example of our ongoing commitment to growing our substantial intellectual property portfolio, which we believe is a key competitive advantage. In addition, we will continue to protect and vigorously enforce our proprietary rights, if necessary."

PROMETHEUS(R) Thiopurine Metabolites helps keep patients' drug metabolite levels within an optimal therapeutic range, thereby increasing the probability of a positive response and potentially reducing the need for other medications. Thiopurine metabolites testing helps identify some of the reasons for treatment failure and monitor for potential toxicity before it occurs.

Combined, Prometheus' thiopurine management diagnostic tests - PROMETHEUS(R) TPMT Genetics and PROMETHEUS(R) TPMT Enzyme for individualizing dosing before therapy, and PROMETHEUS(R) Thiopurine Metabolites for optimizing dosing during therapy - provide information that helps physicians better manage therapeutic treatment, achieve better clinical outcomes and lower the potential for toxicity.

About Thiopurines

Thiopurines are a class of drugs that include azathioprine and mercaptopurine. These drugs are ind
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SOURCE Prometheus Laboratories Inc.
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