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Promega and Cellular Dynamics Partner to Validate Stem Cell-Based In Vitro Assays for Predicting Drug-Induced Cardiotoxicity
Date:6/15/2010

Cellular Dynamics International (CDI) and Promega have entered into a research collaboration with the goal of bringing more relevant and highly predictive toxicity testing to the drug discovery process.

Madison, WI (PRWEB) June 15, 2010 -- Cellular Dynamics International (CDI) and Promega have entered into a research collaboration with the goal of bringing more relevant and highly predictive toxicity testing to the drug discovery process. Pharmaceutical discovery scientists will now be able to combine bioassays with human cardiomyocytes to improve prediction of unintentional, detrimental side effects that have previously remained undetected until late in the development process or after release of the drug to the general public.

Currently CDI has validated a panel of cell-based cytotoxicity assays from Promega that use CDI’s human induced pluripotent stem (iPS) cell-derived iCellTM Cardiomyocytes. Data presented at the recent Society of Toxicology and the Society of Biomolecular Sciences conferences by CDI demonstrate that Promega’s multiplexed biomarker assays for cytotoxicity and cell viability can be used to identify known toxic agents with similar sensitivity as reported in the published literature (see figure).

CDI and its pharmaceutical collaborators have begun validating such assays in order to incorporate them into their routine discovery programs. Chris Parker, CDI’s chief commercial officer, noted, “Pharmaceutic
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Promega and Cellular Dynamics Partner to Validate Stem Cell-Based In Vitro Assays for Predicting Drug-Induced Cardiotoxicity 
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