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Presentation of Phase IIa Results for Cytos Biotechnology's Hypertension Vaccine at the American Heart Association Scientific Sessions 2007
Date:11/6/2007

ity, high fat diet, and high salt intake promote high blood pressure. Up to 30% of adults in most countries suffer from hypertension. Despite effective and relatively inexpensive treatment available, only about one out of four hypertensive individuals in the U.S. have their blood pressure controlled successfully(3). This poor overall treatment success is mainly attributed to the symptomless nature of hypertension and the necessity for long-term treatment with medications that require at least once daily self-administration.

About Early Morning Blood Pressure

Blood pressure is not static but undergoes natural variations which follow a circadian pattern. Highest levels are reached during the morning, which then decline to reach a trough value at about midnight. In the early morning, a steep increase in blood pressure occurs naturally. It has been suggested that this morning rise in blood pressure triggers adverse cardiovascular events. A large study has revealed a marked circadian periodicity in the onset of myocardial infarction with the primary peak incidence being in the morning. At this time, myocardial infarction is three times as likely to onset as during the night(4). The same periodicity was observed in the onset of stroke. Striking evidence suggests that the morning rise in blood pressure is crucial in determining the rupture of critically weakened arterial walls and subjects with a large rise in morning blood pressure have a significantly elevated risk of intracerebral haemorrhage(5) and stroke(6). Hypertension therapy therefore aims at a full 24-hour blood pressure control. Current small molecule inhibitors of the RAS were reported to achieve an ambulatory blood pressure reduction from baseline in the early morning hours of e.g. (SBP / DPB) - 8.7 / - 5.8 mmHg (valsartan) and - 11.0 / - 7.6 mmHg (telmisartan), respectively. They, however, do not abolish the rise in early morning blood pressure(7,8).

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