Navigation Links
Predicting the fate of stem cells
Date:10/22/2013

University of Toronto researchers have developed a method that can rapidly screen human stem cells and better control what they will turn into. The technology could have potential use in regenerative medicine and drug development. Findings are published in this week's issue of the journal Nature Methods.

"The work allows for a better understanding of how to turn stem cells into clinically useful cell types more efficiently," according to Emanuel Nazareth, a PhD student at the Institute of Biomaterials & Biomedical Engineering (IBBME) at the University of Toronto. The research comes out of the lab of Professor Peter Zandstra, Canada Research Chair in Bioengineering at U of T.

The researchers used human pluripotent stem cells (hPSC), cells which have the potential to differentiate and eventually become any type of cell in the body. But the key to getting stem cells to grow into specific types of cells, such as skin cells or heart tissue, is to grow them in the right environment in culture, and there have been challenges in getting those environments (which vary for different types of stem cells) just right, Nazareth said.

The researchers developed a high-throughput platform, which uses robotics and automation to test many compounds or drugs at once, with controllable environments to screen hPSCs in. With it, they can control the size of the stem cell colony, the density of cells, and other parameters in order to better study characteristics of the cells as they differentiate or turn into other cell types. Studies were done using stem cells in micro-environments optimized for screening and observing how they behaved when chemical changes were introduced.

It was found that two specific proteins within stem cells, Oct4 and Sox2, can be used to track the four major early cell fate types that stem cells can turn into, allowing four screens to be performed at once.

"One of the most frustrating challenges is that we h
'/>"/>

Contact: Erin Vollick
Comm.ibbme@utoronto.ca
416-946-8019
University of Toronto
Source:Eurekalert

Page: 1 2

Related biology technology :

1. Expanded Findings for FirstMarks Completed Clinical Study for Predicting Near-Term (2-3 Years) MI
2. Physical cues help mature cells revert into embryonic-like stem cells
3. Cleaner and greener cities with integrated transparent solar cells
4. Direct induction of chondrogenic cells from human dermal fibroblast culture by defined factors
5. Researchers discover and treat toxic effects of ALS mutation in neurons made from patients skin cells
6. Global Stem Cells Group, Inc. Announces Worldwide Alliance with EmCyte Corp. to Promote In-office Regenerative Medicine Solutions
7. Global Industry Analysts, Inc. Announces the Launch of a Major Research Program Analysing the Global Market for Circulating Tumor Cells and Cancer Stem Cells
8. Histogen’s Method of Generating Multipotent Stem Cells Receives US Patent
9. New nanoparticles make solar cells cheaper to manufacture
10. Growing Industry in Technologies For Circulating Tumor Cells: Kalorama Report
11. Decellularized mouse heart beats again after regenerating with human heart precursor cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/26/2015)... , Aug. 26, 2015  Roka Bioscience, Inc. (NASDAQ: ... providing advanced testing solutions for the detection of foodborne ... present at the Sidoti & Company Emerging Growth Conference ... be held at the New York Marriott Marquis. ... be available through the investor relations section of Roka ...
(Date:8/26/2015)... , Aug. 26, 2015  The Diabetes ... the University of Miami Miller School of Medicine, ... clinical trial to test for the first time ... successfully completed.  This FDA approved Phase I/II study ... transplantation and is an important first step toward ...
(Date:8/26/2015)... , Aug. 26, 2015 Intrexon Corporation ... announced today the closing of its previously announced public ... by the underwriters of their option to purchase an ... offering price of $41.00 per share.  The exercise of ... of common stock sold by Intrexon to 5,609,756 shares ...
(Date:8/26/2015)... , Aug. 26, 2015 China Cord Blood ... China,s leading provider of cord blood collection, ... storage services, today announced that the Company has been ... an entity wholly owned by Mr. Yuen Kam, chairman ... acquired the outstanding shares (the "Shares") of  Excellent China ...
Breaking Biology Technology:Diabetes Research Institute Successfully Transplants First Patient In Pilot BioHub Trial 2Diabetes Research Institute Successfully Transplants First Patient In Pilot BioHub Trial 3Diabetes Research Institute Successfully Transplants First Patient In Pilot BioHub Trial 4Intrexon Announces Closing of $230 Million Public Offering of Common Stock including Full Exercise of Underwriters' Option to Purchase Additional Shares 2Intrexon Announces Closing of $230 Million Public Offering of Common Stock including Full Exercise of Underwriters' Option to Purchase Additional Shares 3Intrexon Announces Closing of $230 Million Public Offering of Common Stock including Full Exercise of Underwriters' Option to Purchase Additional Shares 4China Cord Blood Corporation Receives Notice of Transactions Regarding its 7% Senior Convertible Notes Due 2017 2China Cord Blood Corporation Receives Notice of Transactions Regarding its 7% Senior Convertible Notes Due 2017 3
... the tiny island nation of The Maldives , hovering just ... and expectations, she would be off the grid. No Internet, no ... maybe not. After 36 hours in transit, we arrived at the ... and out into the humid night air. Greeting us on the ...
... of TomoTherapy's focus has been on sales in ... the sale is to a hospital that bears the name ... and device manufacturer has sold its Hi-Art system to the ... prize winning physicist and chemist Marie Curie , also ...
... sky. It's a bird. It's a plane. It's super hype - ... single bound. Indeed, lately the media has been saturated with stories ... the mass exodus of Baby Boomers from the workforce. , ,Many ... trend and its impacts on businesses are black and white. But ...
Cached Biology Technology:Coveted vacation "disconnect" was elusive 2Coveted vacation "disconnect" was elusive 3Shades of gray: Business impacts of an aging workforce 2Shades of gray: Business impacts of an aging workforce 3Shades of gray: Business impacts of an aging workforce 4Shades of gray: Business impacts of an aging workforce 5Shades of gray: Business impacts of an aging workforce 6
(Date:8/12/2015)... 12, 2015  New research unveiled at Black ... phones to steal users, fingerprints. Information released today ... fingerprint scanners on mobile devices, making the security ... biometrics on mobile devices, HYPR Corp. recently released ... authentication systems with strong cryptographic security. More information ...
(Date:8/11/2015)... 11, 2015 Today, ZUK announced its Android ... well as expected revenues in 2015 that relate to sales of ... guidance of approximately 2,200 MSEK for 2015. Jörgen Lantto, ... prominent smartphone manufacturer in China ... selected FPC1 155 for Z1 ...
(Date:8/10/2015)... , August 10, 2015 The ... offers comprehensive analysis of the global border security ... generate revenues of $16.4bn in 2015. Now: Border ... is an example of the business critical issue you need ... read visiongain ,s objective analysis of how this will ...
Breaking Biology News(10 mins):HYPR Corp. Addresses Android Vulnerability That Exposes Ecosystem-wide Biometric Security Challenges 2HYPR Corp. Addresses Android Vulnerability That Exposes Ecosystem-wide Biometric Security Challenges 3FPC's Touch Fingerprint Sensor FPC1155 in ZUK's Smartphone Z1 2Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 2Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 3Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 4Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 5Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 6Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 7Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 8Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 9
... H. Blackburn, PhD, 60, of the University of California, San ... in Physiology or Medicine. Blackburn shares the award with ... and Jack W. Szostak of Harvard Medical School. The ... normal cell function, as well as in cell aging and ...
... Upgrade Extends Range to Beyond-Line-of-Sight Communications Through Integration ... Terminals , WASHINGTON, Oct. 5 ... (NYSE: HRS ), an international communications and ... broadband satellite data capability to its JTRS-approved Falcon ...
... WASHINGTON (October 5, 2009) To help draw attention to ... (PCNA) has released findings from a new national consumer survey ... the leading cause of death in the U.S. The ... Americans incorrectly believe that the processes related to heart disease ...
Cached Biology News:UCSF scientist receives Nobel Prize in Physiology or Medicine 2UCSF scientist receives Nobel Prize in Physiology or Medicine 3Harris Corporation Adds Broadband Satellite Data Mode to JTRS-Approved Falcon III(R) AN/PRC-117G Multiband Manpack Radio 2Harris Corporation Adds Broadband Satellite Data Mode to JTRS-Approved Falcon III(R) AN/PRC-117G Multiband Manpack Radio 3Americans concerned about heart health, but not proactive enough to prevent it 2
...
... Topo I, Wild Type Liquid. In ... DTT, 200 µM EDTA, 20% glycerol, pH 7.9. ... I) is a monomeric protein of 765 amino ... the relaxation of both positive and negative supercoiled ...
RNase-Free DNase 50 l...
Request Info...
Biology Products: