Navigation Links
Preclinical study shows heroin vaccine blocks relapse
Date:5/6/2013

vaccine alone; ideally for human patients, the vaccine would be given with other treatments."

Keeping the Drug Out of the Brain

The researchers confirmed that the vaccine sequesters heroin and 6-acetylmorphine in the bloodstream, keeping it out of the brain. The vaccine did not block the effects of methadone, buprenorphine and other opioid-receptor-targeting drugs that are commonly used in addiction therapy. "It doesn't affect the opioid system per se, so in principle you could give this vaccine to heroin-dependent people and continue to treat them with standard therapies, too," Schlosburg said. "Opioid painkillers such as codeine or oxycodone also would continue to work."

Janda notes that in some other trials of drug vaccines and therapies, rats have been known to compensate for the reduced drug effects by doubling or tripling their intake. "But with this heroin vaccine, they don't try to load up more heroin to beat the vaccinewhich is pretty impressive," he said.

Janda expects to make minor changes to the heroin vaccine for trials in humans, but said, "We think it's now about as good as it can be." He is now actively seeking a pharmaceutical company partner to sponsor those clinical trials and, assuming that they go well, to eventually market the vaccine.


'/>"/>

Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert

Page: 1 2 3

Related biology technology :

1. Preclinical Stage Partnering Terms and Agreements in Pharma and Biotech, 2013 Edition
2. arGEN-X advances ARGX-113 into preclinical development for autoimmune disorders
3. Translating Preclinical Pharmacology to Clinical Activity with Myriad RBM’s Inflammation MAP
4. PROLOR Biotech To Present New Preclinical Data On Its Long-Acting Clotting Factor VIIa At Leading European Scientific Conference
5. RPCI-Led Study: FAK Inhibitor Proves Effective Against Brain Tumors in Preclinical Studies
6. Stemline Therapeutics, Inc. Announces Presentations of SL-401 Updated Clinical Trial Results in Acute Myeloid Leukemia (AML) and Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN) and SL-101 Preclinical Efficacy Data Against Hodgkins Lymphoma at
7. Inovio Pharmaceuticals Cytomegalovirus (CMV) Synthetic Vaccine Constructs Generate Strong and Broad T-Cell Responses in Preclinical Study
8. Karyopharm Therapeutics Announces Oral Presentation at the American College of Rheumatology (ACR) on the use of Selective Inhibitors of Nuclear Export (SINE) CRM1 Antagonists in preclinical models of Systemic Lupus Erythematosus (SLE)
9. Preclinical data shows 100 percent prevention and treatment of influenza with engineered human antibody
10. Karyopharm Therapeutics announces the Publication of Two Preclinical Studies on the Activity of Selective Inhibitors of Nuclear Export (SINE) in Acute Myeloblastic Leukemia (AML)
11. MultiCell Technologies Announces Positive Preclinical Results for MCT-465 and MCT-485 in Primary Liver Cancer In Vitro Models
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2014)... Md., Sept. 30, 2014 BioHealth Innovation, ... commercializing market-relevant biohealth innovations and increasing access to early-stage ... today that venture capitalist, Tania Fernandez , Ph.D., ... Dr. Fernandez will be a member of the management ... provide up to $50 million in seed and early-stage ...
(Date:9/30/2014)... iLab Solutions announced the results of ... which focuses on core facility operations, growth and utilization ... today. , In its 4th year running, a number ... the year-over-year decrease in the percentage of revenue that ... feeling the constraints of this trend. When asked, “What ...
(Date:9/30/2014)... Springfield, Mo. (PRWEB) September 30, 2014 ... participate at ISPE Boston Product Show 2014. The Boston ... has booked the 23rd annual, day-long event for Wed., ... The show promises to be the largest in ISPE ... scheduled and upward of 3,000 attendees expected. , ...
(Date:9/30/2014)... MA (PRWEB) September 30, 2014 ... (UC) and collaboration company is dedicated to supporting ... connectivity needs. Julie Power, a carrier ... to ensure collaboration solutions stays connected and productive ... to the increased movement of businesses to cloud ...
Breaking Biology Technology:Seasoned Life Sciences Venture Capitalist Tania Fernandez Joins BHI to Help Manage New BioHealth Gap Fund 2iLab Solutions Announces the Results of the 2014 Core Facility Benchmarking Study 2iLab Solutions Announces the Results of the 2014 Core Facility Benchmarking Study 3HOLLOWAY AMERICA to Exhibit at ISPE Boston Product Show 2014 2HOLLOWAY AMERICA to Exhibit at ISPE Boston Product Show 2014 3SoundConnect Expands Carrier Services Division 2
... , July 23 Applications are now being accepted ... examination. Qualified candidates can take the three-hour exam during the ... globe. , , , ... order to earn the CMPP credential, candidates must meet a defined ...
... NEW YORK , July 22 Reportlinker.com announces that a new market research report ... Bioinformatics Market - Advanced Technologies, ... , , http://www.reportlinker.com/p0243111/Bioinformatics-Market---Advanced-Technologies-Global-Forecast-and-Winning-Imperatives-2009---2014.html ... Report description , ...
... of Nature , scientists from Empa and the Max ... for the first time to grow graphene ribbons that are ... method. Graphene ribbons are considered to be hot candidates for ... width and edge shape. Transistors on the basis of ...
Cached Biology Technology:Applications for the September ISMPP Certified Medical Publication Professional Exam Now Being Accepted 2Applications for the September ISMPP Certified Medical Publication Professional Exam Now Being Accepted 3Reportlinker Adds Bioinformatics Market - Advanced Technologies, Global Forecast and Winning Imperatives (2009 - 2014) 2Reportlinker Adds Bioinformatics Market - Advanced Technologies, Global Forecast and Winning Imperatives (2009 - 2014) 3Reportlinker Adds Bioinformatics Market - Advanced Technologies, Global Forecast and Winning Imperatives (2009 - 2014) 4Reportlinker Adds Bioinformatics Market - Advanced Technologies, Global Forecast and Winning Imperatives (2009 - 2014) 5Reportlinker Adds Bioinformatics Market - Advanced Technologies, Global Forecast and Winning Imperatives (2009 - 2014) 6Reportlinker Adds Bioinformatics Market - Advanced Technologies, Global Forecast and Winning Imperatives (2009 - 2014) 7Reportlinker Adds Bioinformatics Market - Advanced Technologies, Global Forecast and Winning Imperatives (2009 - 2014) 8Reportlinker Adds Bioinformatics Market - Advanced Technologies, Global Forecast and Winning Imperatives (2009 - 2014) 9Reportlinker Adds Bioinformatics Market - Advanced Technologies, Global Forecast and Winning Imperatives (2009 - 2014) 10Reportlinker Adds Bioinformatics Market - Advanced Technologies, Global Forecast and Winning Imperatives (2009 - 2014) 11Reportlinker Adds Bioinformatics Market - Advanced Technologies, Global Forecast and Winning Imperatives (2009 - 2014) 12Reportlinker Adds Bioinformatics Market - Advanced Technologies, Global Forecast and Winning Imperatives (2009 - 2014) 13Reportlinker Adds Bioinformatics Market - Advanced Technologies, Global Forecast and Winning Imperatives (2009 - 2014) 14Reportlinker Adds Bioinformatics Market - Advanced Technologies, Global Forecast and Winning Imperatives (2009 - 2014) 15Reportlinker Adds Bioinformatics Market - Advanced Technologies, Global Forecast and Winning Imperatives (2009 - 2014) 16Reportlinker Adds Bioinformatics Market - Advanced Technologies, Global Forecast and Winning Imperatives (2009 - 2014) 17Reportlinker Adds Bioinformatics Market - Advanced Technologies, Global Forecast and Winning Imperatives (2009 - 2014) 18Reportlinker Adds Bioinformatics Market - Advanced Technologies, Global Forecast and Winning Imperatives (2009 - 2014) 19Reportlinker Adds Bioinformatics Market - Advanced Technologies, Global Forecast and Winning Imperatives (2009 - 2014) 20Reportlinker Adds Bioinformatics Market - Advanced Technologies, Global Forecast and Winning Imperatives (2009 - 2014) 21Nanoribbons for graphene transistors 2Nanoribbons for graphene transistors 3
(Date:9/29/2014)... PULLMAN, Wash. Scientists at Washington State University ... specifically, Granny Smith apples may help prevent ... be the first to assess these compounds in ... in October,s print edition of the journal ... apples are a good source of these nondigestible ...
(Date:9/29/2014)... online in Behavioral Brain Research provides novel ... a result of chronic alcohol exposure that can lead ... assessments and research indicate that individuals with alcohol use ... occur when people are actively drinking, when they are ... , "Sleep-wake disturbances can last for months, or even ...
(Date:9/29/2014)... years ago when the supercontinent of Pangea was starting to ... entirely different kinds of reptiles called phytosaurs and rauisuchids were ... widely believed the two top predators didn,t interact much as ... ruled the land. But those ideas are changing, thanks largely ... paper published online in September in the German journal ...
Breaking Biology News(10 mins):An apple a day could keep obesity away 2Tooth buried in bone shows prehistoric predators tangled across land, sea 2
... part of Biotesting Europe, a new 358,000 biometrics project, ... that future testing procedures and facilities meet the needs ... growing industry. Biometric recognition systems measure unique behavioural ... as varied as iris images, fingerprints, the structure of ...
... smoking can be harmful, if not deadly. While the desire ... factors also play an important role. The etiology of these ... the environment. Adoption and twin studies have shown that the ... studies have provided evidence that ones sex can influence the ...
... new imaging technique developed at MIT has allowed scientists to ... a method similar to the X-ray CT scans doctors use ... a paper published in the Aug. 12 online edition of ... images yet of what goes on inside a living cell ...
Cached Biology News:UK scientists working to help cut ID theft 2Does the desire to consume alcohol and tobacco come from our genetic makeup? 2Does the desire to consume alcohol and tobacco come from our genetic makeup? 3MIT creates 3-D images of living cell 2
...
HistoScan AP Universal Goat Kit...
Interact with both DNA and RNA; fluorescence green (Em=525 nm) bound to DNA; and fluorescence red (Em=~650 nm) bound to RNA....
One bottle containing 30 ml of protein solution and 0.1% sodium azide....
Biology Products: