Navigation Links
Preclinical study shows heroin vaccine blocks relapse
Date:5/6/2013

developed the vaccine three years ago.

Janda and his team therefore designed the heroin vaccine to elicit antibodies against not only heroin, but also 6-acetylmorphine and morphine. "The vaccine effectively tracks the drug as it is metabolized, keeping the active breakdown products out of the brain, and that, I think, explains its success," Janda said.

Rigorous Tests

Initial tests, reported in 2011, showed the vaccine could block some of the acute effects of heroin, such as obstructing pain. In the new study, the Koob laboratory put the vaccine through more rigorous tests.

"We gave the vaccine to rats that had already been exposed to heroin, a situation obviously relevant to a human clinical situation," said postdoctoral research associate Joel Schlosburg, who was first author of the study.

In one test, rats trained to press a lever three times to get an infusion of heroin later went through sessions of "extinction training," in which lever presses no longer produced infusions. Among rats that had not received the heroin vaccine, a single infusion of heroin could immediately reinstate a rat's drug-seeking lever-pressing behaviorjust as human users relapse to drug-seeking after re-exposure to heroin. However, rats that had been vaccinated failed to resume their heroin-seeking lever-presses.

In an even more challenging test, rats that had become severely addicted to heroin and were taking it compulsively in escalating amountsamounts that would have been lethal to drug-nave ratswere forced to abstain for 30 days before being given renewed access. In rats that had received a dummy vaccine, intake resumed and they re-escalated, taking the drug compulsively. But in the heroin-vaccinated rats, intake failed to escalate and compulsive drug taking did not redevelop.

"Basically we were able to stop them from going through that cycle of taking more and more heroin," said Schlosburg. "And that was with the
'/>"/>

Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert

Page: 1 2 3

Related biology technology :

1. Preclinical Stage Partnering Terms and Agreements in Pharma and Biotech, 2013 Edition
2. arGEN-X advances ARGX-113 into preclinical development for autoimmune disorders
3. Translating Preclinical Pharmacology to Clinical Activity with Myriad RBM’s Inflammation MAP
4. PROLOR Biotech To Present New Preclinical Data On Its Long-Acting Clotting Factor VIIa At Leading European Scientific Conference
5. RPCI-Led Study: FAK Inhibitor Proves Effective Against Brain Tumors in Preclinical Studies
6. Stemline Therapeutics, Inc. Announces Presentations of SL-401 Updated Clinical Trial Results in Acute Myeloid Leukemia (AML) and Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN) and SL-101 Preclinical Efficacy Data Against Hodgkins Lymphoma at
7. Inovio Pharmaceuticals Cytomegalovirus (CMV) Synthetic Vaccine Constructs Generate Strong and Broad T-Cell Responses in Preclinical Study
8. Karyopharm Therapeutics Announces Oral Presentation at the American College of Rheumatology (ACR) on the use of Selective Inhibitors of Nuclear Export (SINE) CRM1 Antagonists in preclinical models of Systemic Lupus Erythematosus (SLE)
9. Preclinical data shows 100 percent prevention and treatment of influenza with engineered human antibody
10. Karyopharm Therapeutics announces the Publication of Two Preclinical Studies on the Activity of Selective Inhibitors of Nuclear Export (SINE) in Acute Myeloblastic Leukemia (AML)
11. MultiCell Technologies Announces Positive Preclinical Results for MCT-465 and MCT-485 in Primary Liver Cancer In Vitro Models
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2014)... Aug. 27, 2014  A novel biomarker for ... physicians better identify early-stage disease, when treatment can ... to a new study in The Journal of ... DGX ) and other institutions found ... outperformed conventional antibody-serum testing, including rheumatoid factor (RF) ...
(Date:8/27/2014)... 27, 2014 Guggenheim Securities, the investment banking ... the hiring of veteran equity analyst Charles "Tony" Butler ... Butler will focus on the biotech/biopharma sector. ... of experience and a broad network of relationships in ... Director and Head of Equities at Guggenheim Securities. "His ...
(Date:8/27/2014)... 2014 Flagship Biosciences LLC, a leading ... the pharmaceutical and medical device industries, has announced a ... growing company has consolidated its histology and tissue analysis ... Westminster, CO, just north of Denver. The new ... 103rd Ave., Suite 100, Westminster, CO 80021 , Tissue ...
(Date:8/27/2014)... Aug. 27, 2014 Research and Markets ... Isotope Ratio Mass Spectrometer Industry Report 2014" report ... Isotope Ratio Mass Spectrometer Industry Report 2014 is a ... the global isotope ratio mass spectrometer industry. ... including definitions, classifications, applications and industry chain structure. The ...
Breaking Biology Technology:Novel Biomarker Detects Early Rheumatoid Arthritis Better than Conventional Methods Alone, According to Journal of Rheumatology Study 2Novel Biomarker Detects Early Rheumatoid Arthritis Better than Conventional Methods Alone, According to Journal of Rheumatology Study 3Novel Biomarker Detects Early Rheumatoid Arthritis Better than Conventional Methods Alone, According to Journal of Rheumatology Study 4Guggenheim Securities Hires Analyst Charles "Tony" Butler to Expand Healthcare Coverage 2Flagship Biosciences Announces Relocation and Expansion 2Global Stable Isotope Ratio Mass Spectrometer Industry Report 2014 2
... As the exclusive official,breaking news service for North ... is featuring profiles of the exhibiting,organizations. The profile Perry ... Perry Baromedical Corporation Booth Number: ... : http://www.perrybaromedical.com Perry Baromedical Corporation is ...
... Implementation Issues and Recommendations, BETHLEHEM, Pa., ... of Clinical Value Marketing, Infusion Systems Division ... Services for B. Braun Medical,Inc. (B. Braun), ... and services,recently represented B. Braun at the ...
... 12 TorreyPines Therapeutics,Inc. (Nasdaq: TPTX ) today ... 2008. For the three-month period, the Company posted,revenue of ... Cash and cash,equivalents totaled $14.3 million at September 30, ... productive as we further,our transition to a development-only company," ...
Cached Biology Technology:Perry Baromedical Corporation Exhibiting at MEDICA 2008 2B. Braun Directors Participate at First ISMP National Smart Pump Safety Summit 2B. Braun Directors Participate at First ISMP National Smart Pump Safety Summit 3TorreyPines Therapeutics Reports Third Quarter 2008 Results and Recent Accomplishments 2TorreyPines Therapeutics Reports Third Quarter 2008 Results and Recent Accomplishments 3TorreyPines Therapeutics Reports Third Quarter 2008 Results and Recent Accomplishments 4TorreyPines Therapeutics Reports Third Quarter 2008 Results and Recent Accomplishments 5TorreyPines Therapeutics Reports Third Quarter 2008 Results and Recent Accomplishments 6TorreyPines Therapeutics Reports Third Quarter 2008 Results and Recent Accomplishments 7
(Date:8/27/2014)... LAKE CITY, Aug. 27, 2014 University of Utah ... his native Turkey, has won that nation,s highest science ... of Science. , Sekercioglu is among five researchers picked ... and Technical Research Council of Turkey. Three researchers won ... won the Special Award, which is equivalent to the ...
(Date:8/27/2014)... what is described by the Volunteer Wildfire Services of ... Cape provincial government warned residents in certain parts of ... veld fires. A high veld fire danger rating ... coast in the Great Kei and Mnquma area. ... thunderstorms. The thunderstorms bring lightning strikes and subsequent ...
(Date:8/27/2014)... release is available in German . ... is the most common inherited disease affecting the peripheral ... the Max Planck Institute of Experimental Medicine and University ... Schwann cells is impaired in rats with the disease. ... layer known as myelin, which facilitates the rapid transfer ...
Breaking Biology News(10 mins):University of Utah biologist wins Turkey's top science prize 2Potential therapy for incurable Charcot-Marie-Tooth disease 2
... biochemists are now able to access 3D images ... than relying on text to provide the understanding ... now provides a new resource by linking written ... resource, first described in BioMed Central,s open access ...
... at The University of Manchester have developed a new ... that could lead to quick testing for serious diseases, ... new drugs. Researchers working at the Manchester Interdisciplinary ... a new technique for producing functional ,protein chips, in ...
... St. Andrews, United Kingdom, have helped determine why relearning a ... a recollection of other associated, previously learned information. The ... learned information is forgotten. Details are published August 22nd ... When one learns a language and then doesn,t use it, ...
Cached Biology News:Chips are down as Manchester makes protein scanning breakthrough 2
... modifications of Eagle's medium have ... formulation. The most widely used ... DME is a modification of ... that contains a higher concentration ...
... Hollandes is a fixative useful for ... fixation. It is stable and will decalcify ... with Hollande's can be stained successfully with ... the solution stabilizes red blood cell membranes ...
... Shimadzus GCMS-QP2010s Gas Chromatograph/Mass Spectrometer, utilizing ... the GCMS-QP2010 Plus, offers high throughput ... an excellent performance-to-cost ratio. Like the ... constant linear velocity for optimum separation, ...
... The Precision XS uniquely combines a ... head and an 8-channel bulk reagent dispenser ... addition to transfers using disposable pipette tips, ... resistant bulk reagent dispenser is available for ...
Biology Products: