Navigation Links
Precisely engineering 3-D brain tissues
Date:12/4/2012

CAMBRIDGE, MA -- Borrowing from microfabrication techniques used in the semiconductor industry, MIT and Harvard Medical School (HMS) engineers have developed a simple and inexpensive way to create three-dimensional brain tissues in a lab dish.

The new technique yields tissue constructs that closely mimic the cellular composition of those in the living brain, allowing scientists to study how neurons form connections and to predict how cells from individual patients might respond to different drugs. The work also paves the way for developing bioengineered implants to replace damaged tissue for organ systems, according to the researchers.

"We think that by bringing this kind of control and manipulation into neurobiology, we can investigate many different directions," says Utkan Demirci, an assistant professor in the Harvard-MIT Division of Health Sciences and Technology (HST).

Demirci and Ed Boyden, associate professor of biological engineering and brain and cognitive sciences at MIT's Media Lab and McGovern Institute, are senior authors of a paper describing the new technique, which appears in the Nov. 27 online edition of the journal Advanced Materials. The paper's lead author is Umut Gurkan, a postdoc at HST, Harvard Medical School and Brigham and Women's Hospital.

'Unique challenges'

Although researchers have had some success growing artificial tissues such as liver or kidney, "the brain presents some unique challenges," Boyden says. "One of the challenges is the incredible spatial heterogeneity. There are so many kinds of cells, and they have such intricate wiring."

Brain tissue includes many types of neurons, including inhibitory and excitatory neurons, as well as supportive cells such as glial cells. All of these cells occur at specific ratios and in specific locations.

To mimic this architectural complexity in their engineered tissues, the researchers embedded a mixture of brain
'/>"/>

Contact: Sarah McDonnell
s_mcd@mit.edu
617-253-8923
Massachusetts Institute of Technology
Source:Eurekalert

Page: 1 2 3

Related biology technology :

1. Pioneering electrical engineering work recognized
2. Engineering plants for biofuels
3. New UCLA Engineering research center to revolutionize nanoscale electromagnetic devices
4. Three Hertz Foundation Fellows Receive Presidential Honors; Leaders in Applied Physical, Biological and Engineering Sciences
5. Two Blades Foundation licenses genome engineering technology to KWS
6. Bronstein, Gewirtz & Grossman, LLC Announces Investigation of American Oriental Bioengineering Inc.
7. Reverse engineering epilepsys miracle diet
8. Trinity College Dublins Neuroscience and Bioengineering Programmes Receive Postgraduate Course of the Year Awards
9. X-BODY BioSciences to Present Novel Methods of Selecting for Antibodies Against Targets on Live Cells at CHIs Protein Engineering Summit
10. Global Genetic Engineering Industry
11. Smart, self-healing hydrogels open far-reaching possibilities in medicine, engineering
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/1/2014)... BELLINGHAM, Washington, USA (PRWEB) September 30, 2014 ... complex yet efficient arrangements that have evolved in nature ... on biomimetic and bioinspired materials for applications in ... of Biomedical Optics . The journal is published by ... the SPIE Digital Library. Several of the peer-reviewed articles ...
(Date:10/1/2014)... 2014 This report analyzes the ... Million by the following Product Segments: Proteases, ... end-use segments also analyzed are Pharmaceuticals & ... report provides separate comprehensive analytics for the ... and Latin America. Annual estimates and forecasts ...
(Date:9/30/2014)... Using a bio-mimicking analog of one of ... an international research team led by Alejandro Briseno ... a major step in developing long-sought polymer architecture ... for use in electronic devices. , Briseno, ... and others at Stanford University and Dresden University ...
(Date:9/30/2014)... Over the last decade, the laboratory filtration market ... and increased acceptance of new filtration technologies in end ... are also catalyzing the growth of laboratory filtration market. ... grow at a strong CAGR during the forecast period ... million by 2019. The market is mainly driven by ...
Breaking Biology Technology:Biomimetic and bioinspired materials enable new healthcare options, reports Journal of Biomedical Optics 2Biomimetic and bioinspired materials enable new healthcare options, reports Journal of Biomedical Optics 3Global Specialty Enzymes Industry 2Global Specialty Enzymes Industry 3Global Specialty Enzymes Industry 4Global Specialty Enzymes Industry 5Global Specialty Enzymes Industry 6Global Specialty Enzymes Industry 7Global Specialty Enzymes Industry 8Global Specialty Enzymes Industry 9Global Specialty Enzymes Industry 10Global Specialty Enzymes Industry 11Global Specialty Enzymes Industry 12Global Specialty Enzymes Industry 13Global Specialty Enzymes Industry 14Global Specialty Enzymes Industry 15Global Specialty Enzymes Industry 16Global Specialty Enzymes Industry 17Global Specialty Enzymes Industry 18Global Specialty Enzymes Industry 19Global Specialty Enzymes Industry 20Global Specialty Enzymes Industry 21Global Specialty Enzymes Industry 22Global Specialty Enzymes Industry 23Global Specialty Enzymes Industry 24Global Specialty Enzymes Industry 25Global Specialty Enzymes Industry 26Blades of grass inspire advance in organic solar cells 2Blades of grass inspire advance in organic solar cells 3Global Laboratory Filtration Market To See 7.0% CAGR to 2019 Says a Research Report Available at ReportsnReports.com 2Global Laboratory Filtration Market To See 7.0% CAGR to 2019 Says a Research Report Available at ReportsnReports.com 3Global Laboratory Filtration Market To See 7.0% CAGR to 2019 Says a Research Report Available at ReportsnReports.com 4Global Laboratory Filtration Market To See 7.0% CAGR to 2019 Says a Research Report Available at ReportsnReports.com 5
... Inc.,a privately held biopharmaceutical company developing anti-inflammatory,drugs, today ... (A-002) at,the American Heart Association (AHA) Annual Conference ... II trials in varespladib for the,treatment of coronary ... its,collaborators released new data from the Phase II ...
... example of the wonders of nanotechnology, in which common substances ... and exciting possibilities. , Graphene is ... carbon, which is used to make the pigment that allows ... a one-atom-thick sheet. Graphene is among the strongest materials known ...
... Inc.,(Nasdaq: SSRX ) ("3SBio" or the "Company"), ... manufacturing and,marketing biopharmaceutical products, today announced its unaudited,financial ... 2008., Third Quarter 2008 Financial Highlights: ... the third quarter 2007 to ...
Cached Biology Technology:Anthera's Varespladib Demonstrates Significant Anti-Inflammatory Effect and LDL Reduction in Patients With Coronary Heart Disease 2Researchers discover method for mass production of nanomaterial graphene 2Researchers discover method for mass production of nanomaterial graphene 33SBio Inc. Announces Third Quarter 2008 Results 23SBio Inc. Announces Third Quarter 2008 Results 33SBio Inc. Announces Third Quarter 2008 Results 43SBio Inc. Announces Third Quarter 2008 Results 53SBio Inc. Announces Third Quarter 2008 Results 63SBio Inc. Announces Third Quarter 2008 Results 73SBio Inc. Announces Third Quarter 2008 Results 83SBio Inc. Announces Third Quarter 2008 Results 93SBio Inc. Announces Third Quarter 2008 Results 103SBio Inc. Announces Third Quarter 2008 Results 113SBio Inc. Announces Third Quarter 2008 Results 123SBio Inc. Announces Third Quarter 2008 Results 133SBio Inc. Announces Third Quarter 2008 Results 143SBio Inc. Announces Third Quarter 2008 Results 15
(Date:9/30/2014)... comprehensive assessment conducted by the Ocean Health Index ... 100 in overall health. In addition, for the ... the 15 ocean regions beyond national jurisdiction (high-seas ... healthy climate, safeguarding biodiversity and providing sustainable food ... the index, a partnership led by scientists from ...
(Date:9/30/2014)... scientists and engineers, led by Clemson University associate ... million grant from the U.S. Department of Energy,s ... a direct positive impact on South Carolina in ... radioactive contaminants. , "Understanding the scientific and engineering ... aspects of nuclear technologies is imperative if South ...
(Date:9/30/2014)... Pollution in urban and farm runoff in Hawaii is ... finds. , The study, published Tuesday in the ... in the runoff ends up in algae that the ... animals, eyes, flippers and internal organs. , Scientists at ... Oceanic and Atmospheric Administration (NOAA) conducted the study to ...
Breaking Biology News(10 mins):Rating the planet's oceans 2Rating the planet's oceans 3Researchers get $5.25 million to advance nuclear technologies in South Carolina 2Pollution linked to lethal sea turtle tumors 2Pollution linked to lethal sea turtle tumors 3
... (SACRAMENTO, Calif.) A majority of women with breast cancer ... of their breast tissue. Results of a UC Davis study, ... in the same breast are treated with a second lumpectomy ... the number of years those women survive in half. ...
... friends to help get what they need and, according to ... of Wisconsin-Madison, many microbes, plants and animals benefit from ,friendly, ... by the National Science Foundation (NSF) and published in the ... describes the complex relationship between a beetle, two types of ...
... S. Dunn Research Foundation has awarded a $3 million ... in biomedical science that have the potential for clinical ... Rice researchers whose studies will be conducted at the ... the corner of University Boulevard and Main Street. To ...
Cached Biology News:Second lumpectomy for breast cancer reduces survival rates 2Beetles get by with a little help from their friends 2
100 ug affinity purified rabbit anti-JIP-1 polyclonal antibody. Reacts with mouse and rat. Perform well in Western blotting. Other applications have not been tested. Storage Temperature: -20C Shi...
...
... to Neuron navigator 1 ( Abpromise for ... Synthetic peptide conjugated to KLH derived from within ... navigator 1. (Note: the amino acid sequence ... ab32208 .) Entrez Gene ...
Na+/H+ exchanger, isoform NHE1....
Biology Products: