Navigation Links
Precisely engineering 3-D brain tissues
Date:12/4/2012

CAMBRIDGE, MA -- Borrowing from microfabrication techniques used in the semiconductor industry, MIT and Harvard Medical School (HMS) engineers have developed a simple and inexpensive way to create three-dimensional brain tissues in a lab dish.

The new technique yields tissue constructs that closely mimic the cellular composition of those in the living brain, allowing scientists to study how neurons form connections and to predict how cells from individual patients might respond to different drugs. The work also paves the way for developing bioengineered implants to replace damaged tissue for organ systems, according to the researchers.

"We think that by bringing this kind of control and manipulation into neurobiology, we can investigate many different directions," says Utkan Demirci, an assistant professor in the Harvard-MIT Division of Health Sciences and Technology (HST).

Demirci and Ed Boyden, associate professor of biological engineering and brain and cognitive sciences at MIT's Media Lab and McGovern Institute, are senior authors of a paper describing the new technique, which appears in the Nov. 27 online edition of the journal Advanced Materials. The paper's lead author is Umut Gurkan, a postdoc at HST, Harvard Medical School and Brigham and Women's Hospital.

'Unique challenges'

Although researchers have had some success growing artificial tissues such as liver or kidney, "the brain presents some unique challenges," Boyden says. "One of the challenges is the incredible spatial heterogeneity. There are so many kinds of cells, and they have such intricate wiring."

Brain tissue includes many types of neurons, including inhibitory and excitatory neurons, as well as supportive cells such as glial cells. All of these cells occur at specific ratios and in specific locations.

To mimic this architectural complexity in their engineered tissues, the researchers embedded a mixture of brain
'/>"/>

Contact: Sarah McDonnell
s_mcd@mit.edu
617-253-8923
Massachusetts Institute of Technology
Source:Eurekalert

Page: 1 2 3

Related biology technology :

1. Pioneering electrical engineering work recognized
2. Engineering plants for biofuels
3. New UCLA Engineering research center to revolutionize nanoscale electromagnetic devices
4. Three Hertz Foundation Fellows Receive Presidential Honors; Leaders in Applied Physical, Biological and Engineering Sciences
5. Two Blades Foundation licenses genome engineering technology to KWS
6. Bronstein, Gewirtz & Grossman, LLC Announces Investigation of American Oriental Bioengineering Inc.
7. Reverse engineering epilepsys miracle diet
8. Trinity College Dublins Neuroscience and Bioengineering Programmes Receive Postgraduate Course of the Year Awards
9. X-BODY BioSciences to Present Novel Methods of Selecting for Antibodies Against Targets on Live Cells at CHIs Protein Engineering Summit
10. Global Genetic Engineering Industry
11. Smart, self-healing hydrogels open far-reaching possibilities in medicine, engineering
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/30/2015)... June 30, 2015 /PRNewswire/ - Resverlogix Corp. ("Resverlogix") ... shares of Resverlogix have approved the resolutions relating ... Limited of 5,600,000 units at a price of ... unit being comprised of one common share and ... of approximately CAD$15 million; and (ii) the amendment ...
(Date:6/30/2015)... -- Today, Americord Registry, one of the fastest growing cord blood ... partner at Kirkland & Ellis LLP, as the newest member ... http://photos.prnewswire.com/prnh/20150630/226958LOGO   "We are thrilled about Andrew ... Smithmyer , CEO of Americord. "He brings a wealth of ... Americord,s growth and vision." Andrew Horne ...
(Date:6/30/2015)... FL (PRWEB) , ... June 30, 2015 , ... The ... 7.76% of Cryo-Cell’s currently outstanding common shares (including shares of unvested restricted stock). On ... offer, the last sale price of Cryo-Cell’s shares reported on the OTCBB was $2.29 ...
(Date:6/30/2015)... 30, 2015 /PRNewswire/ - RepliCel Life Sciences Inc. ... medicine company focused on the development of autologous ... its Phase 1/2 clinical trial of RCT-01, being ... tendinosis, has been enrolled and their tissue biopsy ... RCT-01 is comprised of non-bulbar dermal sheath (NBDS) ...
Breaking Biology Technology:Resverlogix Corp. Shareholders Approve Matters Relating to Licensing and Equity Arrangement 2Resverlogix Corp. Shareholders Approve Matters Relating to Licensing and Equity Arrangement 3Americord Registry Announces Andrew Horne as Advisory Board Member 2Cryo-Cell Commences Tender Offer to Purchase its Common Stock, Up to 750,000 Shares at $3.25 per Share 2Cryo-Cell Commences Tender Offer to Purchase its Common Stock, Up to 750,000 Shares at $3.25 per Share 3RepliCel Life Sciences Enrolls First Participant in Phase 1/2 Clinical Trial of RCT-01 for Chronic Achilles Tendinosis 2RepliCel Life Sciences Enrolls First Participant in Phase 1/2 Clinical Trial of RCT-01 for Chronic Achilles Tendinosis 3RepliCel Life Sciences Enrolls First Participant in Phase 1/2 Clinical Trial of RCT-01 for Chronic Achilles Tendinosis 4
... PRINCETON, N.J., May 13, 2011 Soligenix, Inc. (OTCBB: ... announced today its financial results for the first quarter ... first quarter of 2011 were approximately $808,000 as compared ... increased revenues were primarily a result of increases in ...
... Texas at Austin,s Cockrell School of Engineering have created ... as a greatly enhanced supercapacitor, holding promise for energy ... to consumer electronics. The findings of the group, ... S. Ruoff, will be published May 12 by ...
... Dan Neumeister, FACHE, principal of Neumeister Healthcare Management Services ... selected by Chase Brexton Health Services (CBHS) of Baltimore, ... effective May 1, 2011. Neumeister is serving in this ... fills the position. As CBHS,s top ...
Cached Biology Technology:Soligenix Reports First Quarter 2011 Financial Results and Reviews Accomplishments 2Soligenix Reports First Quarter 2011 Financial Results and Reviews Accomplishments 3Soligenix Reports First Quarter 2011 Financial Results and Reviews Accomplishments 4Soligenix Reports First Quarter 2011 Financial Results and Reviews Accomplishments 5Enhanced electrical energy storage may result from professor's research 2Regional Healthcare Management Firm Goes National 2
(Date:6/30/2015)... YORK , June 30, 2015 To bolster ... security provider HYPR Corp. announced today the addition of two ... will serve as board advisor and David Raviv ... the team underscore HYPR Corp.,s commitment to providing the most ... Dimitri Sirota co-founded Layer 7 Technologies, a provider ...
(Date:6/30/2015)... , June 30, 2015 Genisphere ... as CEO to help further develop Genisphere,s therapeutics capabilities ... partnering experience, having spent much of the last 25 ... Amgen, Baxter Bioscience, and Johnson & Johnson. Tom started ... Technology and Biotech Corporate Finance. He graduated from Dartmouth ...
(Date:6/29/2015)... Research and Markets( http://www.researchandmarkets.com/research/zj7h4f/latin_america ) has ... Sensors Market - Growth, Trends & Forecasts (2014-2020)" ... Biomedical Sensors market is estimated at $0.65 billion by ... 2014-2020 The near future will bring Biomedical ... each individual. These sensors can be set to trigger ...
Breaking Biology News(10 mins):HYPR Corp. Expands Biometric Authentication Team with Enterprise All Stars 2HYPR Corp. Expands Biometric Authentication Team with Enterprise All Stars 3Genisphere Appoints New CEO, Thomas Bliss 2Genisphere Appoints New CEO, Thomas Bliss 3Latin America Biomedical Sensors Market Report 2015-2020 2
... Cold Spring Harbor Laboratory (CSHL) today announced the launch ... communication -- a new, free service, called bioRxiv (pronounced "bio-Archive"). ... to share the results of their work before peer review ... reading its contents costs nothing. Each paper is given ...
... Virginia: November 12, 2013: An invention that strips cancer ... a better way to shock hearts back into their normal ... inventing competition. "We had a fantastic diversity of creative ... Competition judge almost as hard as being an inventor," said ...
... of energy from as many photons as possible is ... and electronic engineering researchers on a quest to boost ... are now running up against limits set by the ... the University of Pennsylvania and Drexel University have experimentally ...
Cached Biology News:CSHL launches bioRxiv, a freely accessible, citable preprint server for biology 2Cancer can't hide; better heart shocks; mechanical leeches 2Penn and Drexel team demonstrates new paradigm for solar cell construction 2Penn and Drexel team demonstrates new paradigm for solar cell construction 3Penn and Drexel team demonstrates new paradigm for solar cell construction 4Penn and Drexel team demonstrates new paradigm for solar cell construction 5
... to BMP2 BMP2 belongs to ... superfamily. Bone morphogenic protein induces bone ... for the autosomal dominant disease of ... Immunogen: Synthetic peptide: PSDEVLSEFELRLLSM conjugated ...
The Microseal 384 plate positioner ensures precise positioning of Microseal 384-well plates in the x-, y-, and z-dimensions, for accurate automated liquid handling....
...
... heat sealer ideal for low to medium throughput ... a wide range of plates of differing heights ... of the sealer is pre-set for optimal sealing ... used in conjunction with ABgenes sealing foil or ...
Biology Products: