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Prana Alzheimer's disease Development Program update
Date:7/17/2014

ut the prospects of a large trial statistically powered to demonstrate cognitive benefit," Prof. Masters said.

IMAGINE EXTENSION TRIAL UPDATE 
Patients who completed the full 12-month term of the IMAGINE trial were eligible for participation in an open-label Extension study. All participants in the Extension study receive a 250mg once daily oral dose of PBT2 for an additional 12 months during which PiB-PET and MRI imaging will continue.

Thirty three patients elected to join the Extension trial and of these, 30 remain on the trial. Of those participants, 21 have now been identified as being randomized to the PBT2 treatment arm in the IMAGINE study. Of these, all 21 patients have completed 14 months of PBT2 administration, 20 have completed 18 months of PBT2 administration and nine have completed 21 months of PBT2 administration.

We are very pleased with the continuing safety profile of the drug. The data safety monitoring board has met a further two times and has not expressed any concerns in relation to adverse events.

Contacts: 
Investor Relations 
Rebecca Wilson,
 T: +61 3 8866 1216, 
E: rwilson@buchanwe.com.au

Media Relations 
Ben Oliver, 
T: +61 3 8866 1233
, E: boliver@buchanwe.com.au

About Prana Biotechnology Limited 
Prana Biotechnology was established to commercialise research into Alzheimer's disease, Huntington disease and other neurodegenerative and movement disorders. The Company was incorporated in 1997 and listed on the Australian Stock Exchange in March 2000 and listed on NASDAQ in September 2002. Researchers at prominent international institutions including The University of Melbourne, The Mental Health Research Institute (Melbourne) and Massachusetts General Hospital, a teaching hospital of
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