Navigation Links
Practice makes perfect -- motor memory possible for neuroprosthetic control
Date:7/20/2009

"Practice makes perfect" is the maxim drummed into students struggling to learn a new motor skill be it riding a bike or developing a killer backhand in tennis. In order to become proficient in any motor task, all that practice must eventually modify the performer's nervous system so that stable motor memories of the physical actions are formed. In this week's issue of PLoS Biology, new research reveals that macaque monkeys can achieve a kind of consolidation of motor memory when using a neuroprosthetic device to complete a motor action. The finding could have a role in increasing the ease with which physically disabled people can master the control of artificial limbs and other disembodied devices.

Scientists at the University of California, Berkeley, taught macaque monkeys to use their own brain signals to move a computer cursor to various targets using a prosthetic device, and as the monkeys learned to proficiently use the robotic device, the researchers monitored their brain signals. The scientists learned that the brain develops a mental map of the solution to the task, and that the neural patterns persisted without deviation, much like a driver sticks to a given route commuting to work.

"When your own body performs motor tasks repeatedly, the movements become almost automatic," said study principal investigator Jose Carmena. "The profound part of our study is that this is all happening with something that is not part of one's own body. We have demonstrated that the brain is able to form a motor memory to control a disembodied device in a way that mirrors how it controls its own body. That has never been shown before."

Researchers have previously demonstrated that rodents, non-human primates and humans are able to control robotic devices or computer cursors in real time using only brain signals. But what had not been clear before was whether such a skill had been consolidated as a motor memory. The new study suggests that the brain is capable of creating a stable, mental representation of a disembodied device so that it can be controlled with little effort.

To demonstrate this, Carmena and Karunesh Ganguly, a post-doctoral fellow in Carmena's laboratory, used a mathematical model, or "decoder." The decoder, analogous to a simplified spinal cord, translated the signals from the brain's motor cortex into movement of the cursor.

It took about four to five days of practice for the monkeys to master precise control of the cursor. Once they did, they completed the task easily and quickly for the next two weeks.

As the tasks were being completed, the researchers were able to monitor the changes in activity of individual neurons involved in controlling the cursor. They could tell which cells were active when the cursor moved in specific directions. The researchers noticed that when the animals became proficient at the task, the neural patterns involved in the "solution" stabilized.

There are three major features scientists associate with motor memory; stability once a motor memory is consolidated it is difficult to change, rapid recall upon demand, and resistance to interference when new skills are learned. All three elements were demonstrated by the macaques in the UC Berkeley study.

To test resistance to interference, the researchers presented a new decoder marked by a different colored cursor two weeks after the monkeys showed mastery of the first decoder.

As the monkeys were mastering the second decoder, the researchers would suddenly switch back to the original decoder and saw that the monkeys could immediately perform the task without missing a beat. The ability to switch back and forth between the two decoders shows a level of neural plasticity never before associated with the control of a prosthetic device.

"This is a study that says that maybe one day, we can really think of the ultimate neuroprosthetic device that humans can use to perform many different tasks in a more natural way," said Carmena.

"Beyond its clinical applications this line of research sheds light on how the brain assembles and organizes neurons, and how it forms a motor memory to control the prosthetic device," Carmena said. "These are important, fundamental questions about how the brain learns in general."


'/>"/>

Contact: Elliot Page
press@plos.org
Public Library of Science
Source:Eurekalert

Related biology technology :

1. Boydens Summit Practice Featured in the September Issue of New Jersey Business Magazine
2. Parexel Consulting Strengthens Good Manufacturing Practice Capabilities in Europe
3. Campbell Alliance Managed Markets Practice to Take Leadership Role at CBIs Formulary and Reimbursement Conference
4. Campbell Alliance Business Development Practice to Moderate Two Workshops at LES Annual Meeting in Vancouver
5. Campbell Alliance Launches New Practice Area Focused on Trade and Distribution
6. Pioneer in Reproductive Medicine Opens The Countrys First Comprehensive Fertility Practice
7. ABCs Private Practice Inaccurately Portrays Serious Womens Health Condition
8. Campbell Alliance Trade and Distribution Practice to Chair CBI 3rd Annual Fee for Service and EDI Data Management Conference
9. Physicians Practice, Loma Linda Partner to Improve Patient Care in Southern California
10. Campbell Alliance Brand Management Practice to Discuss Managing Launch Logistics at the EyeForPharma Oncology Summit
11. Campbell Alliance Brand Management and Managed Markets Practices to Speak at CBIs Early Commercialization Conference
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/20/2017)... (PRWEB) , ... April 20, 2017 , ... ... to the scientific and clinical research community’s growing body of knowledge during its ... in the Gracie Theatre and the adjacent Darling Atrium. During the event, undergraduates, ...
(Date:4/20/2017)... , ... April 20, 2017 , ... Parallel6™ , ... trials worldwide, announced today that they were named one of the 2017 Top ... the latest developments in the pharmaceutical industry. , “We take pride in honoring Parallel6 ...
(Date:4/20/2017)... , April 20, 2017 For ... focuses on novel drug development and clinical research aimed at ... Biostage Inc. (NASDAQ: BSTG), Keryx Biopharmaceuticals Inc. (NASDAQ: KERX), Kite ... ZIOP ). You can access our complimentary research reports ... ...
(Date:4/19/2017)... ... 2017 , ... Optofluidics today announced that it's changing its ... changed focus to making analytical tools for biopharmaceutical quality control. “We are excited ... Robert Hart. Founders Bernardo Cordovez, Robert Hart and David Erickson have steered the ...
Breaking Biology Technology:
(Date:4/3/2017)... April 3, 2017  Data captured by ... platform, detected a statistically significant association between ... to treatment and objective response of cancer ... to predict whether cancer patients will respond ... as well as to improve both pre-infusion potency ...
(Date:3/28/2017)... March 28, 2017 The report ... (Camera, Monitors, Servers, Storage Devices), Software (Video Analytics, VMS), ... - Global Forecast to 2022", published by MarketsandMarkets, the ... and is projected to reach USD 75.64 Billion by ... 2022. The base year considered for the study is ...
(Date:3/23/2017)... Mar. 23, 2017 Research and Markets has ... Analysis & Trends - Industry Forecast to 2025" report to ... ... a CAGR of around 8.8% over the next decade to reach ... analyzes the market estimates and forecasts for all the given segments ...
Breaking Biology News(10 mins):