Navigation Links
Potentia Pharmaceuticals' Drug Candidate for Age-Related Macular Degeneration Shows Positive Safety Profile in Phase I Clinical Trial
Date:11/10/2008

Based on this mechanism of action, POT-4 holds the potential to be effective against both dry and wet AMD.

About AMD

AMD is the leading cause of blindness in the elderly of the western world and affects more than 10 million patients in the United States alone. The current standard of care for AMD relies primarily on angiogenesis inhibitors, an approach geared towards the approximately 10-15% of AMD patients with complications resulting from ocular angiogenesis (growth of new blood vessels and bleeding in the back of the eye). No drug currently on the market has been approved for the treatment of the remaining patients, who suffer from the so- called "dry" form of the disease.

About the Complement System and POT-4

Complement activation is an inflammatory process involving dozens of plasma proteins, ultimately leading to cell membrane disruption through the membrane attack complex (MAC). Activation of the complement system is an important part of the body's defensive immune response against pathogens such as bacteria and viruses. In spite of its defensive function, inappropriate or excessive complement activation can have destructive consequences if left unchecked. Over the past three years, multiple scientific publications have strongly linked variants of genes encoding components of the complement system with a predisposition toward AMD.

POT-4 binds tightly to complement component C3, preventing its participation in the complement activation cascade. As C3 is the central component of all major complement activation pathways, its inhibition effectively shuts down downstream complement activation that could otherwise lead to local inflammation, tissue damage and upregulation of angiogenic factors such as vascular endothelial growth factors (VEGF).

About Potentia

Potentia Pharmaceuticals, Inc. is an early stage biotechnology company focused on developing novel therapeutics and drug delivery technologies to address chron
'/>"/>

SOURCE Potentia Pharmaceuticals, Inc.
Copyright©2008 PR Newswire.
All rights reserved

0

GOOD

Page: 1 2 3

Related biology technology :

1. Systems Medicine (SM), a Subsidiary of Cell Therapeutics, Inc. (CTI), Announces Execution of CRADA with NCI/NIH to Develop Potential Cancer Treatments Targeting the Insulin Growth Factor (IGF) Pathway
2. Study Published in Clinical Cancer Research Confirms Potential Of Peregrines Bavituximab Combined With Radiation In Lung Cancer
3. Gladstone scientists uncover potential mechanism of memory loss in Alzheimers disease
4. New Data Presented on Immunocytokine Fusion Protein Further Supports Broad Anti-Cancer Potential Of Peregrines Anti-PS Technology Platform
5. Pharmaceutical Product Launch: Commercially Focused R&D Increases Drugs Market Potential
6. Agendia Acquires Rights to the Discovery of a Major Drug Resistance Mechanism in Breast Cancer Potentially Leading to a Herceptin(R) Sensitivity Test
7. AEterna Zentaris to Further Develop Three Follow-up Multi-targeted Cytotoxic Candidates to AEZS-112 as Potential Novel Cancer Treatment
8. Lexicon Files Investigational New Drug Application for LX1032 as a Potential Treatment for Carcinoid Syndrome
9. Discovery of creator gene for cerebral cortex points to potential stem cell treatments
10. Research Using Thermo Fisher Scientific RNA-Interference Technology Unveils Potential New Targets for HIV Drugs
11. Study by Leading Economist Identifies Potential for $378 Billion of Savings From Follow On Biologics
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/23/2013)... May 23, 2013  BioScrip, Inc. (NASDAQ: ... at the Jefferies 2013 Global Healthcare Conference to be ... York. Richard Smith , ... Tran , Chief Financial Officer, will present on ... Time.   About BioScrip BioScrip, Inc. ...
(Date:5/23/2013)... May 23, 2013 Graphite Metallizing ... self-lubricating bushings mounted in stainless steel pillow blocks. ... of GRAPHALLOY with the application and installation versatility ... Pillow Blocks work exceptionally well when submerged ... hostile liquids such as acids, alkalies, hydrocarbons, black ...
(Date:5/23/2013)... Wis. , May 23, 2013 ... researcher, developer, and marketer of over-the-counter (OTC) medicinal ... its research opinion on the company based on ... , Non-Prescription, All Natural Product to ... the Product Outperforms #1 Prescription Competitor , ...
(Date:5/23/2013)... CA (PRWEB) May 23, 2013 The ... encourage all types of inventions. They focus on learning ... noticing this community gravitate toward bringing their ideas to ... DIY Biology Movement, works on making projects using biology. ... DNA of plants to make them glow with bioluminescence ...
Breaking Biology Technology:Graphite Metallizing Now Offers GRAPHALLOY® Stainless Steel Pillow Blocks for Success in Submersible Applications 2Graphite Metallizing Now Offers GRAPHALLOY® Stainless Steel Pillow Blocks for Success in Submersible Applications 3PuraMed BioScience (PMBS) Issued Alert Based on Market Cap of $721,756 2PuraMed BioScience (PMBS) Issued Alert Based on Market Cap of $721,756 3Glowing Plant Releases Maker Kit, Enabling Anyone to Make a Glowing Plant at Home 2
... BNA Books , a division of BNA , announces ... of Biotechnology and the Federal Circuit , ... the entire body of Federal Circuit precedent in the rapidly ...   Biotechnology and the Federal Circuit, ...
... Medivation, Inc. (Nasdaq: MDVN ) today announced ... present at the 29th Annual J.P. Morgan Healthcare Conference on ... Westin St. Francis Hotel in San Francisco. ... clinical development programs for MDV3100 for prostate cancer and dimebon ...
... advanced technology to create high-quality dental lab products quickly ... DentalLab.com ( http://www.dentallab.com ), a new full-service dental laboratory ... around the world. DentalLab.com was founded in ... entrepreneur with a successful track record of establishing and ...
Cached Biology Technology:New Second Edition of Biotechnology and the Federal Circuit Examines the Court's Decisions on Chemical, Biotechnology, and Pharmaceutical Patent Law Cases 2New Second Edition of Biotechnology and the Federal Circuit Examines the Court's Decisions on Chemical, Biotechnology, and Pharmaceutical Patent Law Cases 3New Second Edition of Biotechnology and the Federal Circuit Examines the Court's Decisions on Chemical, Biotechnology, and Pharmaceutical Patent Law Cases 4Cutting-Edge Technologies Position DentalLab.com as Emerging Leader in Dental Lab Services Outsourcing 2
(Date:5/23/2013)... genomic DNA around nucleosomes in the cell nucleus ... of Ludwig-Maximilians-Universitaet (LMU) in Munich now describes a ... displaced from nucleosomes for transcription. , In higher ... cell nucleus, wrapped around disk-shaped particles called nucleosomes, ... histone proteins and accommodating two loops of DNA. ...
(Date:5/23/2013)... history museums of the world are billions of animal ... flowers, mushrooms and grasses, all stacked, stored and preserved ... diverse collections could be critical to understanding how the ... growing human footprint if only the information were ... life with the help of a team from the ...
(Date:5/22/2013)... National Lung Screening Trial (NLST) investigators also conclude ... mortality with low-dose computed tomography (LDCT) versus chest ... primary paper is achievable at experienced screening centers ... more information to share with their patients about ... screening following today,s publication in the New ...
Breaking Biology News(10 mins):Biochemistry: Unspooling DNA from nucleosomal disks 2CU-Boulder helps tap crowds to digitize museum records of bugs and plants 2CU-Boulder helps tap crowds to digitize museum records of bugs and plants 3CU-Boulder helps tap crowds to digitize museum records of bugs and plants 4NLST: CT detects twice as many lung cancers as X-ray at initial screening exam 2NLST: CT detects twice as many lung cancers as X-ray at initial screening exam 3
... are finding new ways to block the movement of cells ... spread of cancer. Led by Professor of Immunology Shaun ... of cells which are involved in helping cells migrate to ... of diseases like cancer and autoimmune diseases, such as multiple ...
... The European Molecular Biology Organization (EMBO) and the Federation ... the German Cancer Research Center in Heidelberg, Germany, as ... Award. Ingrid Grummt has made important contributions to the ... The FEBS/EMBO Women in Science Award, now in ...
... the ACSS has collected a number of stories which demonstrates ... improve everyone,s wellbeing. The impact of social science research is ... healthy diets and the wellbeing of children. As ... her research on the value of fathers and grandparents in ...
Cached Biology News:2010 FEBS/EMBO Women in Science award honors Ingrid Grummt 2
... new Hummingbird has the ability to quickly and ... makes it a perfect candidate for inclusion in ... OCX interface supplied with all the Cartesian products ... Hummingbirds ability to copy plates in seconds ...
Sigmas E-TOXATE (Limulus Amebocyte Lysate) test kits are intended for the detection and semiquantitation of endotoxins for research purposes. sensitivity 0.05-0.1 EU/mL...
... isolation chamber provides a safe, clean ... pharmaceuticals, in accord with USP-797 requirements. ... (ISO 5) cleanliness conditions in the ... rod and tilt-up front panel for ...
... Protein determined by Biuret. Physical ... (NH 4 ) 2 SO ... Note: Affinity purified • Physical ... Additives: MgCl 2 1 ...
Biology Products: