Navigation Links
Possible New Way to Detect, Monitor Liver Disease Without Painful Liver Biopsy
Date:12/19/2007

Hepatitis B Foundation says discovery suggests earlier treatment could

benefit patients

DOYLESTOWN, Pa., Dec. 19 /PRNewswire/ -- Scientists working at the Hepatitis B Foundation, in partnership with Drexel University College of Medicine, think they may have discovered a reliable alternative to liver biopsy for the early detection of liver fibrosis and cirrhosis, which afflict more than 5 million Americans. People with hepatitis B and C infections, as well as fatty liver diseases, are at greatest risk for progressing to cirrhosis that can lead to liver cancer.

Successful treatment depends on the early detection of fibrosis and cirrhosis. Currently, detection involves a surgical liver biopsy, which is an unpleasant, expensive procedure and carries some risk. Patients and doctors would prefer tests that are "not invasive" such as a blood test to detect and monitor liver disease.

Lead investigators Drs. Anand Mehta and Timothy Block report in the upcoming Journal of Virology, which appears online next week and in print February 2008, their discovery that the blood of most, if not all, people they tested with a diagnosis of liver cirrhosis, contains high levels of a special antibody that recognizes a carbohydrate sugar commonly found on bacteria. Detection of this antibody in the blood of an affected person correlates very well with a diagnosis of increasing fibrosis and cirrhosis in the new study.

"This is a fascinating discovery and is important because, if confirmed, the test could help us replace liver biopsy as a method for staging liver disease. In addition, it may be teaching us something about how liver disease occurs," said David Thomas, M.D., Chief, Infectious Diseases, Johns Hopkins School of Medicine, Baltimore, MD.

Working with the National Cancer Institute (NCI) Early Detection Research Network, the researchers have been able to test this approach in 300 blood samples from people with liver disease, and can conduct the new test in thousands. Although the test is still experimental and more is needed before it can be used to monitor disease, the discovery is promising.

"If this work is validated, it may offer a new, non-invasive way to test for liver disease, allowing people to either avoid biopsy or to know when they really need one. It also implies that bacteria may have a much bigger role in initiating liver disease than realized, and even lead to new therapies," said Block.

Complications from bacteria in people with cirrhosis are well understood; however, bacteria are not usually seen early in the disease. The significance of this new discovery may suggest earlier treatments with antibiotics could benefit patients with chronic liver disease.

About the Hepatitis B Foundation

The Hepatitis B Foundation is the only national nonprofit organization solely dedicated to finding a cure and improving the quality of life for those affected with hepatitis B worldwide through research, education and patient advocacy. Visit http://www.hepb.org or call (215) 489-4900 for more information.
Available Topic Expert(s): For information on the listed expert(s), click appropriate link. Dr. Timothy Block http://profnet.prnewswire.com/Subscriber/ExpertProfile.aspx?ei=66704 Joan Block http://profnet.prnewswire.com/Subscriber/ExpertProfile.aspx?ei=66707


'/>"/>
SOURCE Hepatitis B Foundation
Copyright©2007 PR Newswire.
All rights reserved

Related biology technology :

1. The University of Nottingham in the British Midlands Announces Development of Possible Hepatitis C Vaccine
2. Symmetry Medical Discloses Accounting Issues at Sheffield, UK Operating Unit and Possible Restatement
3. Signalifes Dr. Harmison Launches Award-Winning Ambulatory Heart Monitor
4. Arena Pharmaceuticals Continues Phase 3 BLOOM Obesity Trial Following Independent Echocardiogaphic Data Safety Monitoring Board Review
5. Arena Pharmaceuticals Continues Phase 3 BLOOM Obesity Trial Following Independent Echocardiographic Data Safety Monitoring Board Review
6. Boston Scientific Releases Remote Monitoring Data from its Wireless LATITUDE(R) Patient Management System
7. Cheetah Medicals NICOM Non-Invasive Cardiac Output Monitor Featured in a Presentation at the Heart Failure Society of America (HFSA) Annual Meeting
8. Monitorforhire.com Adds Mobile Phone Capability Further Speeding Access to Experienced Monitors
9. Masimo Launches Patient SafetyNet and Showcases the Rainbow SET Upgradable Noninvasive Monitoring Platform at 2007 ASA Annual Meeting
10. AMDL Submits Data to FDA for Clearance to Market Its DR-70(R) Diagnostic Test to Monitor Colorectal Cancer Patients
11. Oridion Launches its Fully Integrated Remote Monitoring System and SARA Software for Improved Patient Safety
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/21/2017)... ... 21, 2017 , ... Frederick Innovative Technology Center, Inc. (FITCI), ... and technology start-ups, is hosting “Celebration Friday” (a festive gathering highlighting client success ... libations and networking at 3:30 p.m. at FITCI’s 4539 Metropolitan Court location, off ...
(Date:4/20/2017)... Yorba Linda, Ca (PRWEB) , ... April 20, ... ... Virtual University Virtual Event , this new webinar will explore challenging patient cases ... are admitted to the hospital, there may be a need for bridging parental ...
(Date:4/20/2017)... INDIANAPOLIS , April 20, 2017  Eli Lilly ... Phase 2 data evaluating galcanezumab for the prevention of ... meeting, which will take place April 22-28, 2017, in ... will present four abstracts at AAN, including safety and ... and factors associated with a reduction in monthly migraine ...
(Date:4/20/2017)... ... April 20, 2017 , ... Husson University will be celebrating ... body of knowledge during its Eighth Annual Research and Scholarship Day ... Atrium. During the event, undergraduates, graduate students, and faculty members from all of ...
Breaking Biology Technology:
(Date:4/6/2017)... -- Forecasts by Product Type (EAC), Biometrics, ... (Transportation & Logistics, Government & Public Sector, Utilities / ... Facility, Nuclear Power), Industrial, Retail, Business Organisation (BFSI), Hospitality ... looking for a definitive report on the $27.9bn Access ... ...
(Date:4/5/2017)... , April 4, 2017 KEY FINDINGS ... anticipated to expand at a CAGR of 25.76% during ... diseases is the primary factor for the growth of ... report: https://www.reportbuyer.com/product/4807905/ MARKET INSIGHTS The global ... product, technology, application, and geography. The stem cell market ...
(Date:3/30/2017)... March 30, 2017  On April 6-7, 2017, Sequencing.com ... Genome hackathon at Microsoft,s headquarters in ... will focus on developing health and wellness apps that ... Hack the Genome is the first hackathon for ... world,s largest companies in the genomics, tech and health ...
Breaking Biology News(10 mins):