Navigation Links
Possible New Way to Detect, Monitor Liver Disease Without Painful Liver Biopsy
Date:12/19/2007

Hepatitis B Foundation says discovery suggests earlier treatment could

benefit patients

DOYLESTOWN, Pa., Dec. 19 /PRNewswire/ -- Scientists working at the Hepatitis B Foundation, in partnership with Drexel University College of Medicine, think they may have discovered a reliable alternative to liver biopsy for the early detection of liver fibrosis and cirrhosis, which afflict more than 5 million Americans. People with hepatitis B and C infections, as well as fatty liver diseases, are at greatest risk for progressing to cirrhosis that can lead to liver cancer.

Successful treatment depends on the early detection of fibrosis and cirrhosis. Currently, detection involves a surgical liver biopsy, which is an unpleasant, expensive procedure and carries some risk. Patients and doctors would prefer tests that are "not invasive" such as a blood test to detect and monitor liver disease.

Lead investigators Drs. Anand Mehta and Timothy Block report in the upcoming Journal of Virology, which appears online next week and in print February 2008, their discovery that the blood of most, if not all, people they tested with a diagnosis of liver cirrhosis, contains high levels of a special antibody that recognizes a carbohydrate sugar commonly found on bacteria. Detection of this antibody in the blood of an affected person correlates very well with a diagnosis of increasing fibrosis and cirrhosis in the new study.

"This is a fascinating discovery and is important because, if confirmed, the test could help us replace liver biopsy as a method for staging liver disease. In addition, it may be teaching us something about how liver disease occurs," said David Thomas, M.D., Chief, Infectious Diseases, Johns Hopkins School of Medicine, Baltimore, MD.

Working with the National Cancer Institute (NCI) Early Detection Research Network, the researchers have been able to test this approach in 300 blood samples from people with liver disease, and can conduct the new test in thousands. Although the test is still experimental and more is needed before it can be used to monitor disease, the discovery is promising.

"If this work is validated, it may offer a new, non-invasive way to test for liver disease, allowing people to either avoid biopsy or to know when they really need one. It also implies that bacteria may have a much bigger role in initiating liver disease than realized, and even lead to new therapies," said Block.

Complications from bacteria in people with cirrhosis are well understood; however, bacteria are not usually seen early in the disease. The significance of this new discovery may suggest earlier treatments with antibiotics could benefit patients with chronic liver disease.

About the Hepatitis B Foundation

The Hepatitis B Foundation is the only national nonprofit organization solely dedicated to finding a cure and improving the quality of life for those affected with hepatitis B worldwide through research, education and patient advocacy. Visit http://www.hepb.org or call (215) 489-4900 for more information.
Available Topic Expert(s): For information on the listed expert(s), click appropriate link. Dr. Timothy Block http://profnet.prnewswire.com/Subscriber/ExpertProfile.aspx?ei=66704 Joan Block http://profnet.prnewswire.com/Subscriber/ExpertProfile.aspx?ei=66707


'/>"/>
SOURCE Hepatitis B Foundation
Copyright©2007 PR Newswire.
All rights reserved

Related biology technology :

1. The University of Nottingham in the British Midlands Announces Development of Possible Hepatitis C Vaccine
2. Symmetry Medical Discloses Accounting Issues at Sheffield, UK Operating Unit and Possible Restatement
3. Signalifes Dr. Harmison Launches Award-Winning Ambulatory Heart Monitor
4. Arena Pharmaceuticals Continues Phase 3 BLOOM Obesity Trial Following Independent Echocardiogaphic Data Safety Monitoring Board Review
5. Arena Pharmaceuticals Continues Phase 3 BLOOM Obesity Trial Following Independent Echocardiographic Data Safety Monitoring Board Review
6. Boston Scientific Releases Remote Monitoring Data from its Wireless LATITUDE(R) Patient Management System
7. Cheetah Medicals NICOM Non-Invasive Cardiac Output Monitor Featured in a Presentation at the Heart Failure Society of America (HFSA) Annual Meeting
8. Monitorforhire.com Adds Mobile Phone Capability Further Speeding Access to Experienced Monitors
9. Masimo Launches Patient SafetyNet and Showcases the Rainbow SET Upgradable Noninvasive Monitoring Platform at 2007 ASA Annual Meeting
10. AMDL Submits Data to FDA for Clearance to Market Its DR-70(R) Diagnostic Test to Monitor Colorectal Cancer Patients
11. Oridion Launches its Fully Integrated Remote Monitoring System and SARA Software for Improved Patient Safety
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/3/2016)... Denver, Colorado (PRWEB) , ... February 03, 2016 ... ... to hospitals, has established a new office dedicated to the North American healthcare ... provide turnkey solutions to healthcare facilities. The company will provide new pneumatic ...
(Date:2/3/2016)... , ... February 03, 2016 , ... ... annual report which summarizes and analyzes nearly 750 unique supply chain ... alert, and analysis service. , Supply chain risk management practitioners subscribe to ...
(Date:2/3/2016)... ... 03, 2016 , ... ZeptoMetrix™ Corporation (ZMC), announced today the ... quality control of molecular assays targeting the Zika Virus. , “Our level of ... President and CEO of ZeptoMetrix, relayed to his Executive Team. “We need to ...
(Date:2/3/2016)... (PRWEB) , ... February 03, 2016 , ... Big games ... who have sacrificed so much for our country. CereScan, a nationally recognized brain diagnostics ... The Wounded Warrior Amputee Football Team (WWAFT) vs. NFL Stars Flag Football Game on ...
Breaking Biology Technology:
(Date:1/13/2016)... 13, 2016 --> ... new market report titled - Biometric Sensors Market - Global ... - 2023. According to the report, the global biometric sensors market was ... to reach US$1,625.8 mn by 2023, expanding at a ... of volume, the biometric sensors market is expected to ...
(Date:1/11/2016)... 11, 2016 Synaptics Incorporated (NASDAQ: SYNA ... announced that its ClearPad ® TouchView ™ ... two separate categories in the 8 th Annual ... Technology Breakthrough. The Synaptics ® TDDI solution enables ... chain, thinner devices, brighter displays and borderless designs. ...
(Date:1/8/2016)... MANCHESTER, United Kingdom , Jan. 8, 2016 /PRNewswire/ ... sensor-based diagnostic products, today announced the closing of a $9 ... investors.  Proceeds from the financing will be used to accelerate ... device for detecting early-stage pressure ulcers. ... after receiving CE Mark approval. The device,s introduction has been ...
Breaking Biology News(10 mins):