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Positive Study Results for Ceftaroline Phase III Clinical Study for the Treatment of Complicated Skin and Skin Structure Infections Presented at ICAAC / IDSA
Date:10/27/2008

agues showed that ceftaroline has the greatest overall in vitro bactericidal activity against community-associated MRSA (CA-MRSA), vancomycin-intermediate S. aureus (VISA), vancomycin-resistant S. aureus (VRSA) and daptomycin non-susceptible S. aureus (DNSSA) compared to vancomycin, daptomycin, clindamycin, linezolid, TMP/SMX, and ceftriaxone.(6)

--Spontaneous mutation frequency and serial passage resistance development studies with ceftaroline (CPT) (Poster C1-185)(7)

Dr. R. Hinshaw and colleagues evaluated the risk of ceftaroline resistance development using an in vitro model. There was no propensity for resistance development to ceftaroline when serially tested against important skin and community-acquired pneumonia pathogens, including methicillin-susceptible S. aureus (MSSA), MRSA, community-acquired MRSA (CA-MRSA), vancomycin-intermediate S. aureus (VISA), penicillin-susceptible S. pneumoniae (PSSP), penicillin-resistant S. pneumoniae (PRSP), and beta-lactamase-negative H. influenzae.(7)

About Complicated Skin and Skin Structure Infections (cSSSIs)

cSSSIs are caused by gram-positive bacteria, such as MRSA, and common gram-negative bacteria.(8) cSSSIs are among the most common infections treated in the hospital setting,(9) and MRSA infections, now the most frequent cause of cSSSI presenting to emergency departments in the United States (U.S.) and the cause of more than 18,000 deaths in 2005, are becoming more common in patients in both the hospital and community settings.(10)

According to the Centers for Disease Control and Prevention, about 70% of bacterial infections are resistant to at least one drug.(11) Many are resistant to multiple drugs making cSSSIs, especially due to MRSA, challenging to treat.(12) cSSSIs can become extremely serious, leading to hospitalization with increased risk for morbidity and mortality and increased healthcare costs.(11) In a study of patients in the emergency room with skin and skin-structure
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SOURCE Forest Laboratories, Inc.
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