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Positive Study Results for Ceftaroline Phase III Clinical Study for the Treatment of Complicated Skin and Skin Structure Infections Presented at ICAAC / IDSA
Date:10/27/2008

eillance data examining ceftaroline in vitro activity against isolates from cSSSI and CAP. Ceftaroline was highly active against over 1,500 gram-positive pathogens isolated from cSSSI in the US and Europe, including methicillin-resistant Staphylococcus aureus (MRSA) and fluoroquinolone-resistant streptococci, thus, providing strong support for the use of this agent in the treatment of complicated skin infections. Furthermore, it was found to be highly active against more than 500 community-acquired respiratory tract clinical isolates, including difficult-to-treat antibiotic-resistant strains.(2,3)

--Activities of ceftaroline, ceftobiprole, and cethromycin against multi-drug-resistant (MDR) Streptococcus pneumoniae isolates from Canadian Bacterial Surveillance Network (CBSN) (Poster C1-3843)(4)

Dr. D. Low and colleagues from the Canadian Bacterial Surveillance Network report that three new antibiotics, cethromycin, ceftaroline, and ceftobiprole, have greater in vitro activity against MDRSP than ceftriaxone. Ceftaroline was eight-fold more active than ceftriaxone and four-fold more active than ceftobiprole against these resistant pathogens, supporting its use in potentially life-threatening infections caused by these bacteria.(4)

--In vitro activity of ceftaroline (CPT) vs. vancomycin (VM) against MRSA and hVISA strains in a pharmacokinetic/pharmacodynamic (PK/PD) model (Poster A-979)(5)

--In vitro activity of ceftaroline against CA-MRSA, VISA, VRSA and daptomycin-non-susceptible Staphylococcus aureus (DNSSA) (Poster C1-162)(6)

Dr. C. Vidaillac and colleagues used an in vitro model system to compare the activity of ceftaroline with vancomycin. Ceftaroline was more active against a S. aureus strain with intermediate susceptibility to vancomycin and showed similar or superior activity against MRSA, suggesting that it may provide a new option for the treatment of antibiotic-resistant S. aureus.(5) In support, Dr. L. Saravolatz and colle
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SOURCE Forest Laboratories, Inc.
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