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Positive Results Reported for Phase I Clinical Trial at UCLA for the Treatment of ADHD in Children Using External Trigeminal Nerve Stimulation (eTNS)
Date:5/20/2013

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"I am very encouraged by the results of this 20 subject open-label study.  The treatment is safe, well received by children and adolescents with ADHD, and has suggested potential as a non-medication ADHD therapy. The results of the study warrant moving forward with a larger double-blind Phase II clinical trial.  I would like to thank members of my team for their hard work and NeuroSigma for supporting this study," said Dr. McGough.

"PET imaging studies we had conducted in humans showed immediate effects of eTNS on activity in centers in the brain associated with attention," said Ian Cook , M.D., Director of the UCLA Depression Research & Clinic Program and Chief Medical Advisor to NeuroSigma. "These observations served as an initial road map for a likely mechanism of action for eTNS on ADHD, and we are very encouraged that the results of Dr. McGough's study showed robust clinical effects.  As has been the case with eTNS trials to date in epilepsy, depression and PTSD, the participants in this study told us that the eTNS device was easy to use at home and there were no significant adverse events related to use of the system.

"These results not only demonstrate that the eTNS system has the potential to provide parents with a non-drug option to manage their children's ADHD and relieve them of worries about their child's use of stimulants, but also provide encouraging data for pediatricians, child psychologists and child psychiatrists who worry about drug side effects and who have concerns about how stimulant drugs may be abused outside the clinical setting," said Dr. Cook.

"We would like to applaud the hard work of Dr. McGough and his clinical team at UCLA for this important work and look forward to continuing to support their activities in the future," added Lodwrick Cook, Chairman of NeuroSigma. 

"ADHD is a very high priority indication for NeuroSigma. We are committed to m
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