Navigation Links
Positive Preclinical Data on Cell Therapy for Spinal Disc Repair Presented at 23rd Annual Meeting of the North American Spine Society
Date:10/16/2008

ST. LOUIS, Oct. 16 /PRNewswire/ -- ISTO Technologies, Inc., a privately held orthobiologics company, today announced positive preclinical data related to its NuQu(TM) injectable cell-based therapy for spinal disc repair. The data was presented in Toronto, Canada at the 23rd Annual Meeting of the North American Spine Society. Studies carried out at the University of California San Francisco (UCSF) Department of Orthopedics were designed to investigate potential applications of ISTO's core cell-based platform technology (juvenile cartilage cells) as a non-invasive procedure for treatment of degenerative intervertebral disc. In these pre-clinical studies, the disc nucleus from adult pigs was removed and replaced with juvenile chondrocytes in a protein gel carrier.

"We are encouraged by the results of the UCSF preclinical studies and we believe ISTO's cell-based therapy may offer a breakthrough for early non- surgical intervention for patients suffering from back pain," said Mitchell Seyedin, Ph.D., President & CEO.

"Because the disc environment is only conducive to highly specialized cells, the purpose of this preclinical study was to evaluate whether juvenile cartilage cells can effectively replace and regenerate cartilage in the nucleus," said Jeffrey Lotz, Ph.D., Director of the Orthopaedic Bioengineering Laboratory at UCSF. "We are very encouraged by the fact, that in several animal studies, these cells have shown the ability to generate cartilage in the disc nucleus in a predictable and consistent basis," said Dr. Lotz.

NuQu is being developed as a non-invasive treatment for degenerative disc disease for patients who are suffering from low back pain and have failed to respond to conservative therapy. The economic and social impact of back pain due to disc degeneration places a tremendous burden on patients, the healthcare system and the overall economy. Today, there is no effective treatment for degenerative disc disease.

Disc de
'/>"/>

SOURCE ISTO Technologies, Inc.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2

Related biology technology :

1. Nile Therapeutics Announces Positive Interim Data from Phase 2a Study of CD-NP in Patients with Heart Failure
2. BioMS Medicals relapsing-remitting multiple sclerosis trial receives positive review from Data Safety Monitoring Board
3. BioMS Medicals phase III U.S. multiple sclerosis trial receives positive safety review from Data Safety Monitoring Board
4. Cepheid Receives FDA Clearance for First On-Demand Diagnostic Test for Life-Threatening MRSA and Staphylococcus aureus From Patient Positive Blood Cultures
5. Kuvan Receives Positive Opinion From CHMP for European Approval
6. InspireMD Announces Enrollment of First Patients in the MGuard(TM) Acute Myocardial Infarction Clinical Trial Data Will be Used to Confirm Initial Positive Results
7. Tengion Scientists Publish Positive Preclinical Findings With Neo-Organ Demonstrating Long-term Durability and Growth With Skeletal Maturation
8. Repligen Announces Publication of Positive Results with Proprietary HDAC Inhibitor in Huntingtons Disease Model
9. Positive SPA Reply From the FDA for TopoTargets Pivotal Trial With Belinostat in PTCL
10. Ondine Announces Presentation of Positive Clinical Trial Results at the American Academy of Periodontologys 94th Annual Meeting
11. Palatin Technologies, Inc. Reports Positive Results of Phase 2a Clinical Study with PL-3994 for the Treatment of Heart Failure

Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/24/2009)... , HOUSTON, Nov. 24 /PRNewswire-FirstCal...vider of electrical and communications systems and...ential markets, announced today that its commercia...Manhattan Torcon JV to install the electrical syst...ment facility at the U.S. Army Medical Research In...
(Date:11/24/2009)... , CALGARY and BLENHEIM, Ontario, Nov. 24 /P...nounced today it is acquiring the assets of Hyland...m, Ontario. The addition of Hyland Seeds will furt...s as the company anticipates the introduction of ...rbicide Tolerant Trait Technology in corn in 2012....
(Date:11/24/2009)... , REYKJAVIK, Iceland, Nove... Inc. (Nasdaq: DCGN ) today announced the approval...kruptcy Court for the District of Delaware,(the "B...ary petition for,relief under Chapter 11 of the Un...urt. , The orders issued by the Bankruptc...
(Date:11/24/2009)... , SEATTLE, Nov. 24 Blue Mar...and the Odessa Public Development Authority (OPDA)...ate,s Community Economic Revitalization Board (CER...e state,s first specialty biochemical biorefinery ...ll significantly speed the development of our bior...
Breaking Biology Technology:Integrated Electrical Services Awarded Contract to Provide Electrical Systems for U.S. Army Medical Research Institute of Infectious Diseases 2Dow AgroSciences Canada Announces Agreement to Acquire Hyland Seeds 2Dow AgroSciences Canada Announces Agreement to Acquire Hyland Seeds 3deCODE genetics, Inc. Announces Approval of First Day Motions by Bankruptcy Court 2deCODE genetics, Inc. Announces Approval of First Day Motions by Bankruptcy Court 3Blue Marble Energy, OPDA Awarded $2M by WA's Community Economic Revitalization Board 2
...roduct Adoption in High-Growth Cell Therapy Market...s, Inc. (OTC Bulletin Board: BLFS), a leading deve... storage and cryopreservation media products for c... has completed an initial series of small animal s... Cancer Research Center on its biopreservation med...
... Workers Consistent Cleaning , and Complete Conf...Sterilization Products (ASP) is pleased to announc...eaner and Reprocessor, the first commercially avai...leaning of endoscopes. The results of the EVOTECH(...of automated endoscope cleaning and high-level dis...
...ire/ -- Epitomics, Inc., the world,s sole provid...herapeutic use, today announced the appointment of...r. An comes to Epitomics from Merck Research Labor...ch. He has over 12 years of experience in drug dis...utical industries, focusing on therapeutic antibod...
Other Biology Technology:BioLife Solutions Completes Safety Studies on HypoThermosol(R) and CryoStor(TM) 2BioLife Solutions Completes Safety Studies on HypoThermosol(R) and CryoStor(TM) 3BioLife Solutions Completes Safety Studies on HypoThermosol(R) and CryoStor(TM) 4ASP Announces Availability of EVOTECH(TM) Endoscope Cleaner and Reprocessor - First Commercially Available System to Eliminate Manual Cleaning of Endoscopes 2Epitomics Appoints Dr. Zhiqiang An as Chief Scientific Officer 2Epitomics Appoints Dr. Zhiqiang An as Chief Scientific Officer 3
(Date:11/25/2009)...sistant professors recently received funding from ...research beneficial to understanding the environme...er Blackwood, assistant professor in the Departmen...pport two separate research projects. , His firs...mmunities and Functions from the Leaf to the Lands...
(Date:11/24/2009)... a protein that may help gut bacteria bind to the ...by probiotic producers to identify strains that ar...iotics need to interact with cells lining the gut ... surfaces in the gut they are more likely to stick... Dr Nathalie Juge from the Institute of Food Resea...
(Date:11/24/2009)...s long held secrets of the earth,s history locked ...een very little information on the environments th...ons of years. Now, a team of researchers from nine...the tune of $10 million dollars by the National Sc...things literally. These scientists will drill thr...
Breaking Biology News(10 mins):Kent State University professors focus research on the environment with grants totaling $890,000 2A sticky solution for identifying effective probiotics 2LSU gets to the bottom of things -- in Antarctica 2VIVIMIND 28TM 29 granted certificate of free sale as food supplement in Italy Premarket notification filed in the U S 51966 1VIVIMIND 28TM 29 granted certificate of free sale as food supplement in Italy Premarket notification filed in the U S 51966 2VIVIMIND 28TM 29 granted certificate of free sale as food supplement in Italy Premarket notification filed in the U S 51966 3Omnicell to Release Second Quarter 2009 Earnings Results on July 23 51961 1Omnicell to Release Second Quarter 2009 Earnings Results on July 23 51961 2Caliper Life Sciences Second Quarter 2009 Financial Results Conference Call Notice 13071 1Caliper Life Sciences Second Quarter 2009 Financial Results Conference Call Notice 13071 2
...nant women or those hoping to start or extend a fa...rugs statins, say scientists. , Current clinical ...egnant should stop taking statins but the advice i...tial for normal fetal development. , Indeed, a 20...s in children of pregnant women using statins sugg...
...rn day concentrations of ground level ozone pollut...hern and temperate mid-latitudes, as shown in a pa...Tree growth, measured in biomass, is already 7% le...e to a 17% reduction by the end of the century. , ...ior to the Industrial Revolution in the mid-1700s;...
... Dec. 8 Building off of the momentum of,September...mity &,Interoperability Tests, Entrust, Inc. (...ePassport leader by being selected to supply the C...ond-generation ePassports based on the,Extended Ac...ation ePassports represent the beginning of an evo...
Other Biology News:Statin warning for pregnant women 2Surface-level ozone pollution set to reduce tree growth 10 percent by 2100 2The Finnish Population Register Centre to Deploy Entrust EAC ePassport CA Solution 2The Finnish Population Register Centre to Deploy Entrust EAC ePassport CA Solution 3The Finnish Population Register Centre to Deploy Entrust EAC ePassport CA Solution 4
Rabbit Anti-Human GORASP2 Polyclonal Antibody, Unconjugated from Proteintech Group, Inc.
FailSafe PCR 2X PreMix B from EPICENTRE Biotechnologies
Rat Whole Blood Non-Sterile Alsevers from Pel-Freez Biologicals
Anti-Endomorphin-2 Polyclonal Antibody, Unconjugated from CHEMICON
Biology Products: