Navigation Links
Positive Preclinical Data on Cell Therapy for Spinal Disc Repair Presented at 23rd Annual Meeting of the North American Spine Society
Date:10/16/2008

ST. LOUIS, Oct. 16 /PRNewswire/ -- ISTO Technologies, Inc., a privately held orthobiologics company, today announced positive preclinical data related to its NuQu(TM) injectable cell-based therapy for spinal disc repair. The data was presented in Toronto, Canada at the 23rd Annual Meeting of the North American Spine Society. Studies carried out at the University of California San Francisco (UCSF) Department of Orthopedics were designed to investigate potential applications of ISTO's core cell-based platform technology (juvenile cartilage cells) as a non-invasive procedure for treatment of degenerative intervertebral disc. In these pre-clinical studies, the disc nucleus from adult pigs was removed and replaced with juvenile chondrocytes in a protein gel carrier.

"We are encouraged by the results of the UCSF preclinical studies and we believe ISTO's cell-based therapy may offer a breakthrough for early non- surgical intervention for patients suffering from back pain," said Mitchell Seyedin, Ph.D., President & CEO.

"Because the disc environment is only conducive to highly specialized cells, the purpose of this preclinical study was to evaluate whether juvenile cartilage cells can effectively replace and regenerate cartilage in the nucleus," said Jeffrey Lotz, Ph.D., Director of the Orthopaedic Bioengineering Laboratory at UCSF. "We are very encouraged by the fact, that in several animal studies, these cells have shown the ability to generate cartilage in the disc nucleus in a predictable and consistent basis," said Dr. Lotz.

NuQu is being developed as a non-invasive treatment for degenerative disc disease for patients who are suffering from low back pain and have failed to respond to conservative therapy. The economic and social impact of back pain due to disc degeneration places a tremendous burden on patients, the healthcare system and the overall economy. Today, there is no effective treatment for degenerative disc disease.

Disc degeneration, thought to be the major cause of back pain, begins in the nucleus and is accompanied by cell death and tissue destruction. Cartilage regeneration is often called the "holy grail" of the orthopedic industry because of its potential to restore function to damaged joints and spinal discs which otherwise have limited healing potential. Cartilage serves as a "shock absorber", protecting all joints including spinal discs from the wear-and-tear experienced during motion.

ISTO Technologies, Inc. is an orthobiologics company focusing on the development of differentiated products for sport medicine, spinal therapy and trauma. ISTO's products are intended for the repair and regeneration of damaged or injured cartilage and bone.

For additional information, visit ISTO Technologies' website at http://www.istotech.com or contact Scott Gill, Chief Financial Officer, by phone at (314) 995-6049.


'/>"/>
SOURCE ISTO Technologies, Inc.
Copyright©2008 PR Newswire.
All rights reserved

Related biology technology :

1. Nile Therapeutics Announces Positive Interim Data from Phase 2a Study of CD-NP in Patients with Heart Failure
2. BioMS Medicals relapsing-remitting multiple sclerosis trial receives positive review from Data Safety Monitoring Board
3. BioMS Medicals phase III U.S. multiple sclerosis trial receives positive safety review from Data Safety Monitoring Board
4. Cepheid Receives FDA Clearance for First On-Demand Diagnostic Test for Life-Threatening MRSA and Staphylococcus aureus From Patient Positive Blood Cultures
5. Kuvan Receives Positive Opinion From CHMP for European Approval
6. InspireMD Announces Enrollment of First Patients in the MGuard(TM) Acute Myocardial Infarction Clinical Trial Data Will be Used to Confirm Initial Positive Results
7. Tengion Scientists Publish Positive Preclinical Findings With Neo-Organ Demonstrating Long-term Durability and Growth With Skeletal Maturation
8. Repligen Announces Publication of Positive Results with Proprietary HDAC Inhibitor in Huntingtons Disease Model
9. Positive SPA Reply From the FDA for TopoTargets Pivotal Trial With Belinostat in PTCL
10. Ondine Announces Presentation of Positive Clinical Trial Results at the American Academy of Periodontologys 94th Annual Meeting
11. Palatin Technologies, Inc. Reports Positive Results of Phase 2a Clinical Study with PL-3994 for the Treatment of Heart Failure
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/23/2016)... 2016  The Biodesign Challenge (BDC), a university competition ... harness living systems and biotechnology, announced its winning teams ... New York City . The ... projects at MoMA,s Celeste Bartos Theater during the daylong ... senior curator of architecture and design, and Suzanne ...
(Date:6/23/2016)... ... June 23, 2016 , ... In a new case report published ... how a patient who developed lymphedema after being treated for breast cancer benefitted from ... the paradigm for dealing with this debilitating, frequent side effect of cancer treatment. ...
(Date:6/23/2016)... , June 23, 2016 On ... session at 4,833.32, down 0.22%; the Dow Jones Industrial Average ... 500 closed at 2,085.45, down 0.17%. Stock-Callers.com has initiated coverage ... INFI ), Nektar Therapeutics (NASDAQ: NKTR ), Aralez ... Inc. (NASDAQ: BIND ). Learn more about these ...
(Date:6/23/2016)... SAN FRANCISCO , June 22, 2016  Amgen ... platinum sponsorship of the QB3@953 life sciences ... improve human health. The shared laboratory space at QB3@953 ... startups overcome a key obstacle for many early stage ... As part of the sponsorship, Amgen launched two "Amgen ...
Breaking Biology Technology:
(Date:6/3/2016)... LONDON , June 3, 2016 /PRNewswire/ ... Transport Management) von Nepal ... ,Angebot und Lieferung hochsicherer geprägter Kennzeichen, einschließlich ... weltweit führend in der Produktion und Implementierung ... an der Ausschreibung im Januar teilgenommen, aber ...
(Date:6/1/2016)... YORK , June 1, 2016 ... Technology in Election Administration and Criminal Identification to Boost ... to a recently released TechSci Research report, " Global ... By Region, Competition Forecast and Opportunities, 2011 - 2021", ... 24.8 billion by 2021, on account of growing security ...
(Date:5/12/2016)... 2016 WearablesResearch.com , a brand of ... results from the Q1 wave of its quarterly wearables ... consumers, receptivity to a program where they would receive ... insurance company. "We were surprised to see ... Michael LaColla , CEO of Troubadour Research, "primarily because ...
Breaking Biology News(10 mins):