Navigation Links
Positive Preclinical Data on Cell Therapy for Spinal Disc Repair Presented at 23rd Annual Meeting of the North American Spine Society
Date:10/16/2008

ST. LOUIS, Oct. 16 /PRNewswire/ -- ISTO Technologies, Inc., a privately held orthobiologics company, today announced positive preclinical data related to its NuQu(TM) injectable cell-based therapy for spinal disc repair. The data was presented in Toronto, Canada at the 23rd Annual Meeting of the North American Spine Society. Studies carried out at the University of California San Francisco (UCSF) Department of Orthopedics were designed to investigate potential applications of ISTO's core cell-based platform technology (juvenile cartilage cells) as a non-invasive procedure for treatment of degenerative intervertebral disc. In these pre-clinical studies, the disc nucleus from adult pigs was removed and replaced with juvenile chondrocytes in a protein gel carrier.

"We are encouraged by the results of the UCSF preclinical studies and we believe ISTO's cell-based therapy may offer a breakthrough for early non- surgical intervention for patients suffering from back pain," said Mitchell Seyedin, Ph.D., President & CEO.

"Because the disc environment is only conducive to highly specialized cells, the purpose of this preclinical study was to evaluate whether juvenile cartilage cells can effectively replace and regenerate cartilage in the nucleus," said Jeffrey Lotz, Ph.D., Director of the Orthopaedic Bioengineering Laboratory at UCSF. "We are very encouraged by the fact, that in several animal studies, these cells have shown the ability to generate cartilage in the disc nucleus in a predictable and consistent basis," said Dr. Lotz.

NuQu is being developed as a non-invasive treatment for degenerative disc disease for patients who are suffering from low back pain and have failed to respond to conservative therapy. The economic and social impact of back pain due to disc degeneration places a tremendous burden on patients, the healthcare system and the overall economy. Today, there is no effective treatment for degenerative disc disease.

Disc degeneration, thought to be the major cause of back pain, begins in the nucleus and is accompanied by cell death and tissue destruction. Cartilage regeneration is often called the "holy grail" of the orthopedic industry because of its potential to restore function to damaged joints and spinal discs which otherwise have limited healing potential. Cartilage serves as a "shock absorber", protecting all joints including spinal discs from the wear-and-tear experienced during motion.

ISTO Technologies, Inc. is an orthobiologics company focusing on the development of differentiated products for sport medicine, spinal therapy and trauma. ISTO's products are intended for the repair and regeneration of damaged or injured cartilage and bone.

For additional information, visit ISTO Technologies' website at http://www.istotech.com or contact Scott Gill, Chief Financial Officer, by phone at (314) 995-6049.


'/>"/>
SOURCE ISTO Technologies, Inc.
Copyright©2008 PR Newswire.
All rights reserved

Related biology technology :

1. Nile Therapeutics Announces Positive Interim Data from Phase 2a Study of CD-NP in Patients with Heart Failure
2. BioMS Medicals relapsing-remitting multiple sclerosis trial receives positive review from Data Safety Monitoring Board
3. BioMS Medicals phase III U.S. multiple sclerosis trial receives positive safety review from Data Safety Monitoring Board
4. Cepheid Receives FDA Clearance for First On-Demand Diagnostic Test for Life-Threatening MRSA and Staphylococcus aureus From Patient Positive Blood Cultures
5. Kuvan Receives Positive Opinion From CHMP for European Approval
6. InspireMD Announces Enrollment of First Patients in the MGuard(TM) Acute Myocardial Infarction Clinical Trial Data Will be Used to Confirm Initial Positive Results
7. Tengion Scientists Publish Positive Preclinical Findings With Neo-Organ Demonstrating Long-term Durability and Growth With Skeletal Maturation
8. Repligen Announces Publication of Positive Results with Proprietary HDAC Inhibitor in Huntingtons Disease Model
9. Positive SPA Reply From the FDA for TopoTargets Pivotal Trial With Belinostat in PTCL
10. Ondine Announces Presentation of Positive Clinical Trial Results at the American Academy of Periodontologys 94th Annual Meeting
11. Palatin Technologies, Inc. Reports Positive Results of Phase 2a Clinical Study with PL-3994 for the Treatment of Heart Failure
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2016)... ... June 24, 2016 , ... While the majority of ... the Cary 5000 and the 6000i models are higher end machines that use the ... of the spectrophotometer’s light beam from the bottom of the cuvette holder. , ...
(Date:6/23/2016)... , ... June 23, 2016 , ... ... release of its second eBook, “Clinical Trials Patient Recruitment and Retention Tips.” Partnering ... retention in this eBook by providing practical tips, tools, and strategies for clinical ...
(Date:6/23/2016)... June 23, 2016   Boston Biomedical , ... compounds designed to target cancer stemness pathways, announced ... granted Orphan Drug Designation from the U.S. Food ... gastric cancer, including gastroesophageal junction (GEJ) cancer. Napabucasin ... to inhibit cancer stemness pathways by targeting STAT3, ...
(Date:6/23/2016)... -- A person commits a crime, and the detective uses ... criminal down. An outbreak of foodborne illness makes ... uses DNA evidence to track down the bacteria that caused ... not. The FDA has increasingly used a complex, cutting-edge technology ... Put as simply as possible, whole genome sequencing is a ...
Breaking Biology Technology:
(Date:6/2/2016)... 2016 Perimeter Surveillance & Detection ... Physical Infrastructure, Support & Other Service  The ... offers comprehensive analysis of the global Border Security ... revenues of $17.98 billion in 2016. Now: ... leader in software and hardware technologies for advanced video ...
(Date:5/12/2016)... 2016 WearablesResearch.com , a brand of ... results from the Q1 wave of its quarterly wearables ... consumers, receptivity to a program where they would receive ... insurance company. "We were surprised to see ... Michael LaColla , CEO of Troubadour Research, "primarily because ...
(Date:4/26/2016)... BANGALORE, India and LONDON ... Infosys Finacle, part of EdgeVerve Systems, a ... ), and Onegini today announced a partnership to ... banking solutions.      (Logo: http://photos.prnewswire.com/prnh/20151104/283829LOGO ... banks to provide their customers enhanced security to ...
Breaking Biology News(10 mins):