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Poniard Pharmaceuticals Reports First Quarter 2008 Financial Results and Corporate Update
Date:5/6/2008

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after three months of therapy or sooner if significant neurotoxicity

develops (Grade 3 or greater). Nephrotoxicities and ototoxicities

were rare and mild.

Based on this promising data, in November 2007 we initiated a

randomized, Phase 2 study comparing picoplatin to oxaliplatin, both

in combination with 5-fluorouracil and leucovorin. We announced

today that we completed the Phase 2 enrollment. This randomized,

controlled 100-patient trial is designed to compare the safety and

efficacy of picoplatin given once every four weeks in combination

with full-dose 5-fluorouracil and leucovorin dosing in the FOLPI

regimen to oxaliplatin in combination with 5-fluorouracil and

leucovorin in the modified FOLFOX-6 regimen.

We currently are on track to generate data from this trial

throughout 2008 and beyond, and will be presenting early Phase 2 and

updated Phase 1 data at ASCO in June this year.

* Prostate Cancer: At the February 2008 ASCO Genitourinary Cancers

Symposium, we reported encouraging safety and efficacy data from our

Phase 1 dose-escalation study of picoplatin in combination with

docetaxel and prednisone in patients with hormone refractory

prostate cancer (HRPC). Picoplatin was safely administered in

combination with full-dose docetaxel and prednisone, the current

standard of care for first-line HRPC patients. The follow-up Phase 2

study completed enrollment late 2007 and we plan to present data

from this study at ASCO this June and at other scientific meetings.

* Oral Picoplatin: In April this year, results were presented from the

ongoing Phase 1 clinical trial of oral picoplatin in patients with

advanced solid tumor malignancies at the Annual Mee
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SOURCE Poniard Pharmaceuticals, Inc.
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