Navigation Links
Poniard Pharmaceuticals Presents Final Results of Phase 1 Study of Picoplatin in Patients with Metastatic Colorectal Cancer
Date:4/21/2009

gression-free survival data at the 2009 American Society of Clinical Oncology Annual Meeting."

The picoplatin data were presented today in a poster session (abstract #3578) during the American Association for Cancer Research's 100th Annual Meeting 2009 at the Colorado Convention Center in Denver. Picoplatin, the Company's lead product candidate, is a new generation platinum chemotherapy agent in clinical development to treat multiple types of cancer. It is designed to overcome platinum resistance associated with chemotherapy in solid tumors.

Phase 1 CRC Study Design and Results

In the Phase 1 study, 73 patients received the FOLPI regimen with picoplatin administered either every two or every four weeks to evaluate safety and identify the maximum tolerated dose and the optimal schedule of FOLPI administration. Patients received a total picoplatin exposure of between 85 mg/m squared and 1,871 mg/m squared.

None of the patients who received picoplatin exhibited severe neuropathy (Grade 3 or 4), as is commonly seen in metastatic CRC patients treated with the FOLFOX regimen at cumulative oxaliplatin doses above 800 mg/m squared. In addition, none of the patients who received picoplatin exhibited severe (Grade 3/4) nephrotoxicity (kidney toxicity) or ototoxicity (hearing toxicity).

The dose limiting toxicities for both the every-four-week regimen and the every-two-week regimen were neutropenia and thrombocytopenia, which were reversible. The maximum tolerated dose of picoplatin in the every-four-week FOLPI schedule was 150 mg/m squared. 150 mg/m squared for the every-four-week FOLPI schedule and 85 mg/m squared for the every-two-week FOLPI schedule achieved 80 percent of the planned dose and support further clinical studies at these doses and schedules. The 150 mg/m squared dose and schedule was selected for evaluation in the ongoing randomized Phase 2 trial.

'/>"/>

SOURCE Poniard Pharmaceuticals, Inc.
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related biology technology :

1. Poniard Pharmaceuticals to Present Final Data from Picoplatin Phase 1 Clinical Trials at American Association for Cancer Researchs 100th Annual Meeting
2. Poniard Pharmaceuticals Reschedules Fourth Quarter and Fiscal 2008 Results Conference Call for Monday, March 16
3. Poniard Pharmaceuticals to Host Fourth Quarter and Year-End 2008 Financial Results Conference Call on March 12
4. Poniard Pharmaceuticals Announces New Efficacy and Safety Data from a Phase 2 Picoplatin Trial in Patients with Prostate Cancer
5. Poniard Pharmaceuticals to Present at the BIO CEO & Investor Conference
6. Poniard Pharmaceuticals Announces Positive Tumor Response and Neuropathy Data from Phase 2 Clinical Trial of Picoplatin in Metastatic Colorectal Cancer
7. Poniard Pharmaceuticals to Present Data from Phase 2 Clinical Trials of Picoplatin in Colorectal and Prostate Cancers
8. Poniard Pharmaceuticals Announces Commercial Supply Agreement for Picoplatin
9. Poniard Pharmaceuticals to Host Third Quarter 2008 Financial Results Conference Call on October 30
10. Poniard Announces Positive Incremental Efficacy and Safety Data from Phase 2 Picoplatin Trial in Patients With Metastatic Colorectal Cancer
11. Poniard Announces Positive Incremental Efficacy and Safety Data From Ongoing Phase 2 Picoplatin Trial in Hormone-Refractory Prostate Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/24/2014)... 2014 GMO corn cases filed across the ... the process of being consolidated in a Kansas federal court ... AG MIR 162 Corn Litigation, MDL No. 2591 in the ... of the Syngenta GMO corn multidistrict litigation (MDL) has been ...
(Date:12/24/2014)... SoundConnect’s 2015 next ... edge communication technology, provide continued education and inform ... series demonstrates online communication features and benefits; empowering ... most innovative and powerful tools. , According to ...
(Date:12/24/2014)... 2014 According to Ross Selinger, President of ... ITRA Global, the national office market continues to be strong, ... is evidenced by the third quarter’s surprising 3.9% GDP, unemployment ... energy costs have held inflation down and the Fed is ...
(Date:12/24/2014)... Nashville, Tenn. (PRWEB) December 23, 2014 Nashville ... was elected treasurer for the American Society for Reproductive Medicine ... research in reproductive medicine. In his new role as ... board and will have a voice in furthering the mission ...
Breaking Biology Technology:Carey Danis & Lowe Reports on Syngenta GMO Corn Transfer Order 2SoundConnect Launches Leading Edge Business Communications Webinar Series 2SoundConnect Launches Leading Edge Business Communications Webinar Series 3ITRA Global Reports Long Island Is Out of Sync With The National Office Market 2ITRA Global Reports Long Island Is Out of Sync With The National Office Market 3Nashville Fertility Center Announces Dr. George A. Hill Selected to Serve as ASRM Treasurer for 2014-15 2Nashville Fertility Center Announces Dr. George A. Hill Selected to Serve as ASRM Treasurer for 2014-15 3
... health officials may not be saying it, but they are ... the deadly avian flu virus begins quietly in scattered areas ... handle on it - with substantial harm done to public ... and one that is exacerbated by the lack of an ...
... - Last Sunday morning, in the free-wheeling environment ... shared secrets and strategies from her forthcoming book, titled ... she expects to publish next year. , ,In her ... Huber provided advice about maximizing efficiency and minimizing hurt ...
... including one from California, to stem cell patents held ... lack merit and underscore the need for serious patent ... of challenging patents, such as those held by WARF, ... the United States Patent and Trademark Office ...
Cached Biology Technology:UW compound counters Avian flu 2UW compound counters Avian flu 3BarCamp talk turns to Internet dating 2BarCamp talk turns to Internet dating 3WARF challenges show need for patent reform 2WARF challenges show need for patent reform 3WARF challenges show need for patent reform 4
(Date:12/17/2014)... Research and Markets ( http://www.researchandmarkets.com/research/s6qzt5/samsung_galaxy_s5 ) has ... - Home Button Synaptics Fingerprint Sensor Technology Analysis" ... http://photos.prnewswire.com/prnh/20130307/600769 Based on a totally different ... the first time a fingerprint sensor in its product. ...
(Date:12/17/2014)... fundamentally transforming the travel experience and nowhere is this ... decade, ePassports, biometric readers, and secure document scanners have ... via eGates and Automated Passport Control (APC) Kiosks at ... across the globe. According to ...
(Date:12/11/2014)... Minn. , Dec. 10, 2014  Data Sciences ... monitoring, has released a new series of digital ... preclinical toxicology researchers. M series, part of the ... collect the best possible physiologic data when incorporating ...
Breaking Biology News(10 mins):Samsung Galaxy S5 - Home Button Synaptics Fingerprint Sensor Technology Analysis 2Automated Border Control (ABC) Transforms the Global Travel Experience With More Than 2500 ABC eGates and APC Kiosks Deployed In Airports, Seaports, and Land Borders Worldwide 2New telemetry implants expected to change how large animal toxicology studies are conducted 2
... has identified a mechanism related to a transcription factor ... variant, thereby initiating a genetic programme which enhances prostate ... important new direction in investigating the mechanisms related to ... risk of prostate cancer and other human diseases. Published ...
... Japan joined forces in a quest to correct a faulty ... Nature , used stem cells to correct a defective ... promise to correct chromosome abnormalities that give rise to birth ... future, it may be possible to use this approach to ...
... 2014 -- Scientists have identified a mutated gene that ... can have devastating lifelong effects. Currently, the tumor can ... The discovery, reported in Nature Genetics , ... the tumors with targeted drugs already in use for ...
Cached Biology News:Nature study discovers chromosome therapy to correct a severe chromosome defect 2Nature study discovers chromosome therapy to correct a severe chromosome defect 3Mutation discovery may improve treatment for rare brain tumor type 2
... Immunodepletion Kit specifically removes 20 of the ... serum in preparation for further proteomics analysis. ... plasma proteome whether you use one- or ... go straight to mass spectrometry. This is ...
... • Small design specifically for western ... ,Trays are specifically designed for staining western ... x 25 mm) of the disposable tray ... a significant cost savings to the user. ...
... the industry's first siRNA sequence design software ... keep these tools consistent with new experimental ... field of RNAi. With the introduction ... design tools, OligoEngine is pleased to offer ...
... The Gene Inspector can perform many sophisticated ... software is much more than just another sequence ... an entire suite of analyses to be performed ... to design custom style sheets which specify exactly ...
Biology Products: