Navigation Links
Poniard Pharmaceuticals Announces Positive Tumor Response and Neuropathy Data from Phase 2 Clinical Trial of Picoplatin in Metastatic Colorectal Cancer
Date:1/14/2009

iple indications, combinations and formulations. The picoplatin data will be presented in a poster session Saturday, January 17th at 12:30 pm Pacific Time (abstract #444/poster #A56) during the American Society of Clinical Oncology's (ASCO) 2009 Gastrointestinal Cancers Symposium in San Francisco.

Phase 2 CRC Trial Design and Updated Results

The randomized, controlled Phase 2 trial is evaluating picoplatin as a neuropathy-sparing alternative to oxaliplatin for the first-line treatment of metastatic CRC in 101 patients who have not received prior chemotherapy. The trial is comparing the safety, including neuropathy, and efficacy of intravenous picoplatin given once every four weeks in combination with bi-weekly 5-fluorouracil and leucovorin (the FOLPI regimen) with oxaliplatin given in combination with 5-fluorouracil and leucovorin in the FOLFOX regimen, which is the current standard of care. Severe neuropathy is commonly seen in CRC patients treated with oxaliplatin in combination with 5-fluorouracil and leucovorin as part of the FOLFOX regimen at cumulative doses above 800 mg/m squared.

The Phase 2 results, scheduled for presentation at the ASCO Symposium, showed that 65 percent of evaluable FOLFOX-treated patients showed evidence of neurotoxicity compared with 28 percent of patients treated with FOLPI. Ten percent of FOLFOX-treated patients exhibited severe (Grade 3/4) neuropathy compared with no FOLPI-treated patients. Nonhematologic adverse events, including acute gastrointestinal toxicity, were similar between the treatment groups. Thrombocytopenia and neutropenia were more frequent and severe with the FOLPI regimen, but manageable.

Anti-tumor activity also was similar in the FOLPI and FOLFOX groups. Of patients in the FOLPI arm, 76 percent achieved disease control (complete response, partial response and stable disease), including one patient with a complete response and seven patients with a
'/>"/>

SOURCE Poniard Pharmaceuticals, Inc.
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related biology technology :

1. Poniard Pharmaceuticals to Present Data from Phase 2 Clinical Trials of Picoplatin in Colorectal and Prostate Cancers
2. Poniard Pharmaceuticals Announces Commercial Supply Agreement for Picoplatin
3. Poniard Pharmaceuticals to Host Third Quarter 2008 Financial Results Conference Call on October 30
4. Poniard Announces Positive Incremental Efficacy and Safety Data from Phase 2 Picoplatin Trial in Patients With Metastatic Colorectal Cancer
5. Poniard Announces Positive Incremental Efficacy and Safety Data From Ongoing Phase 2 Picoplatin Trial in Hormone-Refractory Prostate Cancer
6. Poniard Pharmaceuticals to Present at the JMP Securities Healthcare Focus Conference
7. Poniard Pharmaceuticals Announces Upcoming Conference Participation
8. Poniard Pharmaceuticals to Present at the 4th Annual Moores UCSD Cancer Center Translational Oncology Symposium
9. Poniard Pharmaceuticals Announces Upcoming Conference Participation
10. Poniard Pharmaceuticals to Host Second Quarter 2008 Financial Results Conference Call on July 31
11. Poniard Pharmaceuticals Appoints Four New Members to Clinical Advisory Board
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2014)... scientists has observed tiny quantum vortices in cold droplets ... Science that the exotic vortices arrange themselves ... the first time that the quantum vortices, which have ... known as superfluid helium, have been detected in nanodroplets. ... Vilesov of the University of Southern California, one of ...
(Date:8/21/2014)... 2014 Telomere Biosciences, LLC (Telomere Biosciences) ... for Dogs" with Telomerase Activation Complex , ... world for dogs. Telomeres are the protective caps ... body. A wealth of ground-breaking research by some ... and Aging, including Nobel laureates, has demonstrated a ...
(Date:8/21/2014)... Aug. 21, 2014 OTC Markets ... Inc., a biotechnology company, on its approval to ... traded on OTCQX®, the best marketplace for established ... Group. Logo - http://photos.prnewswire.com/prnh/20110118/MM31963LOGO ... successful execution of its growth strategy and achievement ...
(Date:8/21/2014)... August 21, 2014 Ontotext S4 ... by Ontotext . Now the same enterprise ... of structured and unstructured data is available to start-ups ... of enterprise technology. Organizations that do not have resources ... management can use S4 since there is no need ...
Breaking Biology Technology:Scientists observe quantum vortices in cold helium droplets 2Telomere Biosciences Announces: TELO-20 for Dogs, the World's First Telomere-Lengthening Supplement for Dogs, to Promote Healthy Aging and Longevity 2Telomere Biosciences Announces: TELO-20 for Dogs, the World's First Telomere-Lengthening Supplement for Dogs, to Promote Healthy Aging and Longevity 3OTC Markets Group Congratulates Immune Pharmaceuticals on NASDAQ Listing 2Ontotext Releases Text Mining & Semantic Technology Running in the Cloud – Welcome to “S4? 2Ontotext Releases Text Mining & Semantic Technology Running in the Cloud – Welcome to “S4? 3Ontotext Releases Text Mining & Semantic Technology Running in the Cloud – Welcome to “S4? 4
... Cedara Software , a Merge Healthcare developer ... with Ft. Lauderdale-based dental imaging company, i-Dent Imaging ... agreement, Cedara will be an exclusive global channel for ... contacts to promote and market this technology to customers ...
... some buzz rustling around the biz about how gaming is going ... UW-System Advanced Distributed Learning Co-Lab are doing some really ... ,Guess what? Gaming is just the tip of an iceberg big ... shop floor to the boardroom. , ,This is a great ...
... receive a $500,000 grant from the Department of Commerce ... Gateway Manufacturing Technology Center in Eau Claire. Nanotechnology is ... of the atom. , ,"Through this project, we are ... expand, and reach its full potential," said Gov. Jim ...
Cached Biology Technology:Just in time for Christmas: Retail IT. 2Just in time for Christmas: Retail IT. 3
(Date:8/21/2014)... a novel and versatile modeling strategy to simulate polyelectrolyte ... as well as for studying polyelectrolytes, including DNA and ... much larger and more complex polyelectrolyte systems, and to ... author of a paper on the work and a ... and Engineering. "This is a big step forward for ...
(Date:8/20/2014)... John and Rebecca Moores Professor of Biology and Biochemistry at ... the International Society for the Study of the Origin of ... two from the U.S., one from France and one ... elected every three years, and 36 have been named since ... countries, the ISSOL includes researchers from disciplines as varied as ...
(Date:8/20/2014)... LAKE CITY Researchers at Huntsman Cancer Institute (HCI) at ... forms of the gene that encodes BCR-ABL, the unregulated ... According to the American Cancer Society, nearly 6,000 new ... Drugs already in use, called tyrosine kinase inhibitors (TKIs), ... They do not cure CML but control it in ...
Breaking Biology News(10 mins):Researchers develop models to study polyelectrolytes, including DNA and RNA 2UH professor named fellow by International Astrobiology Society 2Blueprint for next generation of chronic myeloid leukemia treatment 2
... The U.S. Federal Court of Appeals has overturned an August ... paving the way for broader exploration of how stem cells ... wide range of currently incurable diseases. The ruling has ... the ban in 2009, and by the nation,s top researchers ...
... NY, April 29, 2011Videoscopy, a groundbreaking new ... Journal of Laparoendoscopic & Advanced Surgical ... Ann Liebert, Inc., publishers ( http://www.liebertpub.com ). ... surgical and microinvasive demonstrations of the latest ...
... new study of the environmental impact of major urban ecosystems, ... Applications . The team includes Joseph P. McFadden and ... Geography. They analyzed environmental data gleaned from the "Twin Cities ... cities of Minneapolis and St. Paul, Minn., and surrounding areas. ...
Cached Biology News:US Appeals Court opens federal funding for stem cell research 2Groundbreaking minimally invasive surgical videojournal launched by Mary Ann Liebert Inc. 2UCSB urban ecosystem research featured in leading ecology journal 2UCSB urban ecosystem research featured in leading ecology journal 3
... Precision-designed for Optimal Microdissection , CapSure HS ... precise and rapid extraction of populations of ... samples with Laser Capture Microdissection., Ensure ... Molecular Analysis , All CapSure LCM Caps ...
... Microdissection , CapSure HS and CapSure Macro ... extraction of populations of pure cells from ... Capture Microdissection., Ensure the Integrity of ... All CapSure LCM Caps have a patented ...
... Precision-designed for Optimal Microdissection , CapSure ... the precise and rapid extraction of populations ... cytology samples with Laser Capture Microdissection., ... Downstream Molecular Analysis , All CapSure LCM ...
... Microdissection , CapSure HS and CapSure Macro ... extraction of populations of pure cells from ... Capture Microdissection., Ensure the Integrity of ... All CapSure LCM Caps have a patented ...
Biology Products: