Navigation Links
Polycystic Kidney Disease Assay at Cornell University Uses Transgenomic's Surveyor Nuclease & WAVE Technology
Date:4/2/2009

OMAHA, Neb., April 2 /PRNewswire-FirstCall/ -- Transgenomic, Inc. (OTC Bulletin Board: TBIO). In a peer-reviewed paper published in the February 2009 issue of the journal Human Mutation, a team at Weill Cornell Medical College New York describes in detail the key advantages of using Transgenomic's Surveyor Nuclease technology for mutation scanning of PKD1 and PKD2, two important genes used in the diagnosis and prognosis of autosomal dominant polycystic kidney disease (ADPKD). The assay showed 100% concordance with the current standard, DNA sequencing, but decreased sequencing requirements by 80%, significantly reducing analysis time and cost.

"This paper is further validation of scanning technology based upon Surveyor Nuclease and the WAVE System." said Dr. Eric Kaldjian, CSO for Transgenomic. "Scanning to identify presence of mutations limits the amount of DNA sequencing required, since it is only necessary for confirmation of identified mutations. This rationale provides a logical and cost-effective improvement to the workflow for analyzing large genes such as PKD1 and PKD2, which Hanna Rennert's team demonstrated elegantly in their paper."

"We have been able to make effective use of Transgenomic's DNA analysis technologies to develop a screening assay for PKD1 and PKD2 that is comparable in sensitivity and specificity to DNA sequencing" said Dr Hanna Rennert, Assistant Professor of Pathology and Laboratory Medicine at Weill Cornell Medical College. "Moreover, the Surveyor assay is highly sensitive, enabling it to detect heterozygous changes not readily detected by sequencing. Indeed we were even able to establish that some samples incorrectly scored as homozygous mutations by DNA sequencing were shown by Surveyor Nuclease to be heterozygous."

ADPKD occurs at a rate of 1/1000 in the US population, affecting 500,000 people in the US and, worldwide, about 10 millio
'/>"/>

SOURCE Transgenomic, Inc.
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related biology technology :

1. Kibow Biotech Strongly Supports World Kidney Day for Maintenance of Healthy Kidney Function
2. Rules-Based Medicine, Inc. Launches Human Kidney Damage Biomarker Panel
3. Kidneys for Transplant Function Earlier and Last Longer When Preserved in a Machine Compared to the Traditional Box of Ice
4. States First Single Incision Robotic Kidney Removal Performed at Henry Ford Hospital
5. Cytochroma and Mitsubishi Tanabe form partnership for chronic kidney disease therapies in U.S. and Asia
6. AlloCure Inc. Closes $14.5MM Series A Round to Develop a Stem Cell Therapy for Acute Kidney Injury
7. Third Annual DaVita Kidney Disease Awareness Walks to Hit 20 Cities in 2008
8. HemoCue Receives First FDA CLIA Waiver in Diagnostics Industry for Quantitative Point-of-Care Test for Microalbuminuria, a Kidney and Cardiovascular Disease Risk Marker
9. Nephrologists and Non-Nephrologists Alike Report Increased Attention on Chronic Kidney Disease
10. NBA All-Star Alonzo Mourning is at the Top of his Game When It Comes to Spreading the Word About Chronic Kidney Disease
11. New Independent Research Study Indicates That Cylexs ImmuKnow Test May Identify Kidney Transplant Patients at Risk for Early Acute Rejection
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/22/2014)... form and develop on platinum nanocubes point the ... and reveal that a nearly 150 year-old scientific ... nanoscale. , Researchers with the U.S. Department of ... used highly sophisticated transmission electron microscopes and an ... mechanisms that control the evolution of facets ...
(Date:8/22/2014)... 22, 2014 Ophthalmic drug delivery ... and challenging endeavors as the anatomy, physiology and ... to the foreign substances. Ocular drug delivery technologies ... medication and minimal use of needles; also it ... and provides specific targeting within the ocular globe. ...
(Date:8/22/2014)... Aug. 22, 2014 Research and Markets ... and China Gel Permeation Chromatography (GPC) Industry Report 2014" ... Global and China Gel Permeation Chromatography (GPC) Industry Report ... state of the global gel permeation chromatography industry with ... provides a basic overview of the industry including definitions, ...
(Date:8/22/2014)... August 22, 2014 The AMA is ... its members in Alaska that Alaska Governor Sean Parnell ... 15, further defining public use of Unmanned Aircraft Systems ... Force. House Bill 255states that it is, “An Act ... captured by an unmanned aircraft system.” It defines State ...
Breaking Biology Technology:Shaping the future of nanocrystals 2Shaping the future of nanocrystals 3Shaping the future of nanocrystals 4Ocular Drug Delivery Technologies Market: Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2014 - 2020 2Ocular Drug Delivery Technologies Market: Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2014 - 2020 3Ocular Drug Delivery Technologies Market: Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2014 - 2020 4Global and China Gel Permeation Chromatography (GPC) Industry Report 2014 2State of Alaska Signs Unmanned Aircraft Systems Bill 2
... FRANCISCO, Calif., Aug. 7 Anesiva,Inc. (Nasdaq: ANSV ... quarter and six months ended June 30, 2008., ... Anesiva as we,introduced Zingo(TM) in the U.S. pediatric hospital ... "In addition, I,m pleased,to report that our Phase 3 ...
... Inc.,(Nasdaq: ITMN ) today announced that Daniel G. ... the Canaccord Adams 28th Annual,Global Growth Conference in Boston ... To access a live audio webcast of the presentation, ... investor relations page of InterMune,s,corporate website at http://www.intermune.com ...
... 7 Medicsight PLC, a subsidiary,of MGT Capital ... industry leader in the,development of Computer-Aided Detection (CAD) ... received approval from the Brazilian regulatory,agency, Agencia Nacional ... David Sumner, Chief Executive of Medicsight, commented: "This ...
Cached Biology Technology:Anesiva Announces Second Quarter 2008 Financial Results and Update 2Anesiva Announces Second Quarter 2008 Financial Results and Update 3Anesiva Announces Second Quarter 2008 Financial Results and Update 4Anesiva Announces Second Quarter 2008 Financial Results and Update 5Anesiva Announces Second Quarter 2008 Financial Results and Update 6Anesiva Announces Second Quarter 2008 Financial Results and Update 7Anesiva Announces Second Quarter 2008 Financial Results and Update 8Medicsight Receives Brazilian State Food and Drug Administration Approval for ColonCAD Software 2Medicsight Receives Brazilian State Food and Drug Administration Approval for ColonCAD Software 3
(Date:8/22/2014)... basic and clinical research and technological advances, the ... offensive spanning multiple fronts. , Work happening in ... find new and more selective therapies for cancer. ... specific enzyme overexpressed in certain cancersand they have ... , Chemistry professor Christopher Cairo and his team ...
(Date:8/22/2014)... American consumers will finally be able to purchase fuel ... as zero-emissions vehicles, most of the cars will run ... that contributes to global warming. , Now scientists at ... uses an ordinary AAA battery to produce hydrogen by ... through two electrodes that split liquid water into hydrogen ...
(Date:8/21/2014)... Nxt-ID, Inc. (OTCQB: NXTD), a biometric authentication ... today that its shares of common stock and the ... its proposed underwritten public offering of common stock and ... Capital Market, subject to closing of its proposed underwritten ... will trade under the symbol "NXTD" and "NXTDW," respectively. ...
Breaking Biology News(10 mins):New enzyme targets for selective cancer therapies 2New enzyme targets for selective cancer therapies 3Stanford scientists develop a water splitter that runs on an ordinary AAA battery 2Stanford scientists develop a water splitter that runs on an ordinary AAA battery 3Nxt-ID Approved for NASDAQ Capital Market Listing 2Nxt-ID Approved for NASDAQ Capital Market Listing 3
... warming in alpine regions is putting pressure on a rare ... released in Climatic Change Letters . In ... of Montana, U.S. Fish and Wildlife Service and National Park ... warning indicators of climate warming in mountain ecosystems. The glaciers ...
... Coastal mangrove forests store more carbon than almost any ... by a team of U.S. Forest Service and university ... Nature Geoscience . ( www.nature.com/naturegeoscience.com ) A ... and Northern research stations, University of Helsinki and the ...
... (April 4, 2011) An international team of researchers ... alcohol consumption, according to a new study published online ... of the National Academy of Sciences . ... that influence alcohol drinking behavior. Study contributors Danielle ...
Cached Biology News:Mangroves among the most carbon-rich forests in the tropics 2Gene involved in predisposition to alcohol consumption identified 2
... • Small design specifically for western blots ... are specifically designed for staining western blots. ... 25 mm) of the disposable tray requires ... significant cost savings to the user. Pour ...
... pLivSelect is a direct ... recombinant identification. Recombinant selection ... survival, eliminating the need ... This quick and inexpensive ...
... Signal Enhancer does for enzyme-/substrate-based blotting what intensifying ... the signal up to 10-fold (or one order ... Western Blot Signal Enhancer membrane treatment is a ... to your current Western blotting protocol. The result ...
... through columns is a well-known separation technique ... applications are in DNA/RNA extraction in microbiology, ... purification in chemical or analytical laboratories. ... Genesis series instruments for smaller scales. The ...
Biology Products: