Navigation Links
PolyU discovers the effect of chemical compound PTU on autophagy in zebrafish embryos, sheds light on cancer medication research
Date:7/10/2020

In most research using the zebrafish model, a chemical compound called 1-phenyl-2-thiourea (PTU) is commonly used to suppress pigment formation in zebrafish embryos, maintaining optical transparency to facilitate microscopic imaging. Over the past three years, the PolyU research team led by Dr MA has been using the zebrafish model to investigate the causes of leukaemia and its relationship with autophagy (self-eating) – a mechanism of metabolism that involves the degradation of cells by lysosomes and the process of cell renewal and regeneration. It is a cellular reaction to various physiological and pathological conditions regulating important processes, including intracellular material turnover, cell death, proliferation, development, ageing and tumourigenesis.

According to Dr Ma, “Upon 0.003% PTU treatment, aberrant autophagosome and autolysosome formation, accumulation of lysosomes and elevated autophagic flux were observed in various tissues and organs of the zebrafish,” He pointed out that “Autophagy is crucial in the process of drug resistance of various cells and over-activation of autophagy may potentially interfere with the efficacy of drugs. The research finding means that when we are using this prominent model to study any autophagy-related processes like cancer, the results may not be truly reflected. These studies could have produced skewed results. Researchers should avoid using PTU in autophagy-related research in the future.” Dr MA added that the team has already suspended the use of PTU in zebrafish research. Light-sheet microscopy, which offers greater imaging depth, will be employed as an alternative, for image autophagy in the zebrafish embryo with pigment for their study on leukaemia.

Furthermore, the new research findings also provide a direct mechanistic link between autophagy and melanoma, suggesting autophagy probably regulates melanoma development and drug resistance through interaction with tyrosinase, a key rate-limited regulator of melanin synthesis. Investigation into details of the molecular mechanism between autophagy and melanoma is expected in the future.

Professor YIP Shea-ping, Head of Department of Health Technology and Informatics, said, “We are pleased to see our research team’s recent discovery published in Autophagy, the highest impact journal in the field. Dr MA has also been invited as co-author for new guidelines on autophagy research using zebrafish embryos, a revision that takes place every four years. With the new guidelines in place, we will be able to modify the way we conduct autophagy-related studies with the zebrafish model and, hopefully, to open the door to new treatments for various deadly diseases.”

Read the full story at https://www.prweb.com/releases/polyu_discovers_the_effect_of_chemical_compound_ptu_on_autophagy_in_zebrafish_embryos_sheds_light_on_cancer_medication_research/prweb17247058.htm.


'/>"/>
Source: PRWeb
Copyright©2020 Vocus, Inc.
All rights reserved


Related biology technology :

1. Polyurethane Resin Industry & Thermoplastic Polyurethane Market (China, Global) Analysis Now at DeepResearchReports.com
2. Global Overview of the Spray Polyurethane Foam (SPF) & One Component Foam (OCF) : Industry Analysis, Size, Share, Trends And Forecast Research Report by Researchmoz
3. EMEA Polyurethane Chemicals & Products Market Analysed & Forecast in In-demand IAL Consultants Report Available at MarketPublishers.com
4. PolyU Strikes a Deal with Kinex Pharmaceuticals
5. Bayer MaterialScience Names BioAmber As Its Supplier For New Product Line - Bio-succinic acid forms backbone of innovative new bio-based polyurethanes for textiles
6. PolyU develops a new class of antibiotic candidates for fighting against superbugs
7. Medical Scientist Discovers an Alternative Treatment for Leukemia Using Alkaline Ionized or Electrolyzed Reduced Drinking Water
8. A CNIO team discovers that senescence also plays a role in embryo development
9. Woman Adopted as a Child Discovers Her Heritage through DNA Spectrum's Ancestry Test
10. Intrepid Advisors Discovers Error in MA Tax Form that can Cost a Business Tens of Thousands
11. Art Experiment At TemptDestiny.com Discovers Science Is Blind
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/10/2020)... ... July 08, 2020 , ... Bode Technology, ... expansion of laboratory operations through its COVID-19 testing service, Bode-CARES . Bode-CARES ... , Bode-CARES provides a turnkey solution that includes a comprehensive collection ...
(Date:7/10/2020)... ... July 09, 2020 , ... Sentien Biotechnologies, Inc., a ... of Allen R. Nissenson, M.D., F.A.C.P., as its Chief Medical Officer. Dr. ... lead product, SBI-101. Dr. Nissenson serves as an Emeritus Professor of Medicine ...
(Date:7/1/2020)... ... June 29, 2020 , ... ... date growth of 40% in 2020, despite many obstacles created as a result ... to increase revenue for its partnered medical practices and medical manufacturers by expanding ...
(Date:6/28/2020)... LAGUNA NIGUEL, Calif. (PRWEB) , ... June 25, 2020 , ... ... today announced the launch of Safe Space™ for businesses of all types to ensure ... and 3D LiDAR. , A Safe Space™ enabled business will provide a ...
Breaking Biology Technology:
(Date:8/21/2020)... (PRWEB) , ... August 20, 2020 , ... ... that Hassan Movahhed , a Clinical Operations executive with expertise in clinical ... has joined the firm as an Expert Consultant. Throughout his career, Mr. Movahhed ...
(Date:8/12/2020)... (PRWEB) , ... August 12, 2020 , ... ... and monitoring systems that are ideal for public health agencies of all sizes. ... contagious diseases and helping at-risk individuals find appropriate health care, Mosio helps public ...
(Date:8/7/2020)... (PRWEB) , ... August 06, 2020 , ... ... to participate in the prestigious National STEM Scholar Program, a unique professional development ... building, and project support for middle school science teachers nationwide. , Created in ...
Breaking Biology News(10 mins):