Navigation Links
Polaris Group and The Ludwig Institute for Cancer Research Ltd Initiate Phase 2 Trial of Amino-Acid Degrading Enzyme, ADI-PEG 20, in Patients with Small Cell Lung Cancer
Date:2/14/2011

NEW YORK and SAN DIEGO, Feb. 14, 2011 /PRNewswire/ -- Polaris Group (Polaris) and The Ludwig Institute for Cancer Research (LICR) today announced the enrollment of the first patient in a Phase 2 clinical trial evaluating ADI-PEG 20 in the treatment of small cell lung cancer (SCLC).  The trial, sponsored by LICR, is enrolling patients at Memorial Sloan-Kettering Cancer Center and Duke University Medical Center and will soon commence at St. Bartholomew's Hospital in London.

This study will evaluate the effectiveness of ADI-PEG 20 in patients with relapsed or refractory SCLC. Patients will be enrolled in two cohorts, each of which will have the sample size determined through a Simon two-stage design. SCLC is the fastest growing and most aggressive form of lung cancer and accounts for approximately 15 percent of all cases. Once diagnosed, few patients survive more than two years with current treatment.

ADI is a microbial enzyme, arginine deiminase, that degrades the amino acid arginine. ADI-PEG 20 is ADI conjugated with polyethylene glycol (PEG).  Since arginine can be internally synthesized in normal cells via the urea cycle, but not in certain cancer cells if they lack the necessary enzyme(s) to make arginine, deprivation of arginine caused by ADI-PEG 20 can selectively kill cancer cells without affecting the growth of normal cells. In preclinical models, ADI-PEG 20 eliminated arginine from the blood and showed substantial anti-tumor activity for arginine-dependent tumors.  In clinical trials, ADI-PEG 20 was also found to safely and efficiently eliminate arginine from the blood, and tumor responses as well as extension in overall survival have been observed in hepatocellular carcinoma and melanoma patients treated with ADI-PEG 20.

Amino acid deprivation is an established approach in the treatment of cancer and is exemplified by asparaginase, a widely used treatment for childhood leukemia. Lloyd J. Old, M.D., Director of the New
'/>"/>

SOURCE Polaris Group
Copyright©2010 PR Newswire.
All rights reserved

0

GOOD

Page: 1 2 3

Related biology technology :

1. Duff & Phelps Acquires Lumin Expert Group To Build Global Intellectual Property Practice
2. Tiens Biotech Group (USA) Reports Second Quarter and Six-Month Results
3. China Bio Energy Holdings Group Reports Second Quarter 2008 Financial Results
4. KJT Group Positions for Substantial Growth
5. Bill Pollock, President and CEO of Pharmagistics Group, Named to PharmaVOICE List of 100 Most Inspiring and Influential Leaders in the Life Sciences
6. GSI Group Accepts Shares in Tender Offer for Excel Technology and Commences Subsequent Offering Period
7. Regenerative Medicine Appoints Cell Therapy Group Consultant to Editorial Board
8. China Pharma Holdings, Inc. Will Attend the Susquehanna Financial Group, LLP (SIG) Beijing Management Summit
9. Sinovac to Present at the Susquehanna Financial Groups Second Annual Beijing Management Summit Conference
10. China Bio Energy Holdings Group Announces Participation in the Susquehanna Second Annual Beijing Management Summit
11. Neptune Technologies successfully completes up to $8.5 million debt financing with Desjardins Group
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/18/2013)... June 18, 2013   Lexicon Pharmaceuticals, Inc. ... company focused on discovering breakthrough treatments for human ... has joined the company as its vice president ... brings extensive commercial experience to Lexicon, including both ... of therapeutic areas. Mr. Northcott has ...
(Date:6/18/2013)... Though health care jobs continued to be added ... Labor Statistics -- the increase was far below the calendar ... care jobs were added in home health care and outpatient ... jobs. Overall, the U.S. unemployment rate stayed flat at 7.6 ... that a total of just over 36,000 job cuts were ...
(Date:6/18/2013)... 18, 2013 PathoGenetix, Inc. ... for rapid bacterial strain typing, announced today that ... company as Vice President of Engineering. Dr. Luckey ... company’s RESOLUTION™ Microbial Genotyping System . The ... instrument, pathogen-specific assay kits, database and software, will ...
(Date:6/18/2013)... June 18, 2013 On June 11, ... released a final decision memorandum concluding that FDG ... subsequent management of anti-tumor strategy, and the agency ... National Oncological PET Registry (NOPR) was developed jointly by ... projects under the Coverage with Evidence Development (CED) program ...
Breaking Biology Technology:John Northcott Joins Lexicon as Vice President of Marketing, Commercial Strategy and Operations 2John Northcott Joins Lexicon as Vice President of Marketing, Commercial Strategy and Operations 3MedZilla Employment Report for June 2013 -- Jobs in Health Care Grow, But at Slower Pace 2MedZilla Employment Report for June 2013 -- Jobs in Health Care Grow, But at Slower Pace 3PathoGenetix Hires Technology Development VP for Resolution Microbial Genotyping System 2PathoGenetix Hires Technology Development VP for Resolution Microbial Genotyping System 3WMIS Welcomes CMS Decision: Expanding Coverage for FDG-PET and Ending NOPR Data 2WMIS Welcomes CMS Decision: Expanding Coverage for FDG-PET and Ending NOPR Data 3
... IRVINE, Calif., Sept. 10 ISTA Pharmaceuticals, Inc. (Nasdaq: ... NewsMakers in the Biotech Industry Conference at 11:30 a.m. Eastern ... in New York, NY. , , ISTA,s ... Silvernail will provide an update on the Company,s commercial and ...
... Md., Sept. 10 Cylex, Inc., a venture-backed global ... in vitro diagnostic products intended to illuminate ... Brad L. Stewart, to chief executive officer and chairman ... in December 2007, Mr. Stewart has successfully led the ...
... , , , DALLAS, Sept. ... (OTC Bulletin Board: ACCP), provided an update today on the Company,s clinical development ... drug that has shown to be active in many ... team recently met with its partners Aosaikang Medicinal Group (ASK) ...
Cached Biology Technology:Cylex, Inc. Appoints Brad L. Stewart as Chief Executive Officer and Chairman of the Board 2Cylex, Inc. Appoints Brad L. Stewart as Chief Executive Officer and Chairman of the Board 3Cylex, Inc. Appoints Brad L. Stewart as Chief Executive Officer and Chairman of the Board 4Access Pharmaceuticals Provides Update on ProLindac(TM)Clinical Development Plan 2Access Pharmaceuticals Provides Update on ProLindac(TM)Clinical Development Plan 3Access Pharmaceuticals Provides Update on ProLindac(TM)Clinical Development Plan 4
(Date:6/18/2013)... Research Council, Laboratory of Molecular Biology, has been ... Young Investigator Award. Torrent is being recognized for ... algorithm to predict antimicrobial regions in proteins. Luis ... now applying this algorithm to interrogate full genomes ... with very appealing results." , Torrent obtained ...
(Date:6/18/2013)... 2013 The herbal extract of a yellow-flowered mountain ... increase the lifespan of fruit fly populations by an ... , But it,s how Rhodiola rosea ... grabbed the attention of study leaders Mahtab Jafari and ... in a manner completely unrelated to dietary restriction and ...
(Date:6/18/2013)... University of Adelaide shows that weight gain and increased ... linked to a higher IQ at early school age. , The ... analysed data from more than 13,800 children who were born full-term. ... , show that babies who put on 40% of their birthweight ... by the time they were six years of age, compared with ...
Breaking Biology News(10 mins):The American Society for Microbiology honors Marc Torrent 2Herbal extract boosts fruit fly lifespan by nearly 25 percent, UCI study finds 2IQ link to baby's weight gain in first month 2
... is a universal phenomenon that occurs in biological ... to population dynamics across thousands of kilometers. ... Synthesis (NIMBioS) is now accepting applications for its ... to be held April 11-13, 2011, at NIMBioS ...
... published in the journal Archives of Toxicology , ... in part caused by poorly-bound iron which causes the ... components of living systems. , These toxins, called hydroxyl ... parts of the body. , In order to protect ...
... antibiotic is consumed, researchers have learned that up to ... This means the drugs can leave the body almost ... of agricultural areas, excreted antibiotics can then enter stream ... discharges from animal feeding operations, fish hatcheries, and nonpoint ...
Cached Biology News:See off Alzheimer's with the color purple 2Virginia Tech engineer identifies new concerns for antibiotic resistance, pollution 2Virginia Tech engineer identifies new concerns for antibiotic resistance, pollution 3
Screening assay to detect the Listeria monocytogenes in food samples by,DNA amplification and molecular hybridization on a microtiter plate....
... HistoMark Biotin Streptavidin-HRP Systems provide ... and intracellular antigens in frozen or ... These systems also facilitate double ... can be performed simultaneously with primary ...
Screening test for the detection of Salmonella sp. by means of DNA amplification, subsequent molecular hybridization and detection on a microtitre plate....
... three step procedure (PCR, Exonuclease III digestion ... one day. The typical cloning efficiency using ... Features and Benefits: , , Universal - ... expression vector , High Cloning Efficiency - ...
Biology Products: